Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload

PLoS Computational Biology - Tập 9 Số 8 - Trang e1003186
Karen van Eunen1,2, Sereh M. J. Simons1, Albert Gerding3,1, Aycha Bleeker1, Gijs den Besten1,2, C. M. L. Touw1, Sander M. Houten4, B. Groen1,2, Klaas Krab5, Dirk‐Jan Reijngoud3,1,2, Barbara M. Bakker1,2
1Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
2Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands
3Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
4Laboratory Genetic Metabolic Diseases, Departments of Clinical Chemistry and Pediatrics, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
5Department of Molecular Cell Physiology, Netherlands Institute for Systems Biology, VU University Amsterdam, Amsterdam, The Netherlands

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