Bioactivities of Phenolics by Focusing on Suppression of Chronic Diseases: A Review

Cheynier, 2013, Plant phenolics: Recent advances on their biosynthesis, genetics and ecophysiology, Plant Physiol. Biochem., 72, 1, 10.1016/j.plaphy.2013.05.009

Manach, 2004, Polyphenols: Food sources and bioavailability, Am. J. Clin. Nutr., 79, 727, 10.1093/ajcn/79.5.727

Nardini, 2002, Absorption of phenolic acids in humans after coffee consumption, J. Agric. Food Chem., 50, 5735, 10.1021/jf0257547

Kawabata, 1991, A tetrastilbene from Carex pumila, Phytochemistry, 2, 645, 10.1016/0031-9422(91)83744-6

Yamada, 2006, Stilbenoids from Kobresia nepalensis exhibiting DNA topoisomerase II inhibition, Phytochemistry, 67, 307, 10.1016/j.phytochem.2005.11.001

Baur, 2006, Therapeutic potential of resveratrol: The in vivo evidence, Nat. Rev. Drug Discov., 5, 493, 10.1038/nrd2060

Aggarwal, B.B., Shishodia, S., and Packer, L. (2006). Protective effects of resveratrol in age-related neurodegenerative diseases and gene regulatory action. Oxidative Stress and Diseases: Resveratrol in Health and Disease, Taylor & Francis Group.

Aggarwal, B.B., Shishodia, S., and Packer, L. (2006). Neuroprotective effects of resveratrol. Oxidative Stress and Diseases: Resveratrol in Health and Disease, Taylor & Francis Group.

Lacy, 2004, Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer, Curr. Pharm. Des., 10, 3797, 10.2174/1381612043382693

Jain, 2012, Coumarin: Chemical and pharmacological profile, J. Appl. Pharm. Sci., 2, 236

Lee, 2011, Inhibitory effect of esculetin on migration, invasion and matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells, Mol. Med. Rep., 4, 337

Nitiema, 2012, In vitro antimicrobial activity of some phenolic compounds (coumarin and quercetin) against gastroenteritis bacterial strains, Int. J. Microbiol. Res., 3, 183

Kostova, 2011, Coumarins as antioxidants, Curr. Med. Chem., 18, 3929, 10.2174/092986711803414395

Anand, 2012, A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease, Bioorgan. Med. Chem., 20, 1175, 10.1016/j.bmc.2011.12.042

Alshikh, 2015, Phenolics of selected lentil cultivars: Antioxidant activities and inhibition of low-density lipoprotein and DNA damage, J. Funct. Foods, 18, 1022, 10.1016/j.jff.2015.05.018

Glories, 1999, Concentration and compositional changes of procyanidins in grape seeds and skin of white Vitis Vinifera varieties, J. Sci. Food Agric., 79, 1601, 10.1002/(SICI)1097-0010(199909)79:12<1601::AID-JSFA407>3.0.CO;2-1

Martinez, 1992, Liquid chromatographic determination of apple pulp procyanidins, J. Liq. Chromatogr., 15, 637, 10.1080/10826079208018822

Saito, 1998, Antiulcer activity of grape seed extract and procyanidins, J. Agric. Food Chem., 46, 1460, 10.1021/jf9709156

Castillo, 2000, Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins) froma grape seeds (Vitis Vinifera): Comparative study versus other phenolic and organic compounds, J. Agric. Food Chem., 48, 1738, 10.1021/jf990665o

Darmon, 1991, Oxygen free radical scavenger capacity in aqueous models of different procyanidins from grape seeds, J. Agric. Food Chem., 39, 1549, 10.1021/jf00009a002

Shahidi, F., and Yeo, J.D. (2016). Review: Insoluble-bound phenolics in foods. Molecules, 21.

Shahidi, F., and Naczk, M. (2004). Phenolics in Food and Nutraceuticals, CRC Press Inc.

Podsedek, 2014, Matrix effects on the stability and antioxidant activity of red cabbage anthocyanins under simulated gastrointestinal digestion, BioMed Res. Int., 2014, 1, 10.1155/2014/365738

Scalbert, 2000, Dietary intake and bioavailability of polyphenols, J. Nutr., 130, 2073, 10.1093/jn/130.8.2073S

Adom, 2002, Antioxidant activity of grains, J. Agric. Food Chem., 50, 6182, 10.1021/jf0205099

Andreasen, 2001, Intestinal release and uptake of phenolic antioxidant diferulic acids, Free Radic. Biol. Med., 31, 304, 10.1016/S0891-5849(01)00585-8

Gibson, 1995, Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics, J. Nutr., 125, 1401, 10.1093/jn/125.6.1401

Yi, 2005, Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis, J. Agric. Food Chem., 53, 7320, 10.1021/jf051333o

Anantharaju, 2016, An overview on the role of dietary phenolics for the treatment of cancers, Nutr. J., 15, 1, 10.1186/s12937-016-0217-2

Yeh, 2011, Gallic acid induces G(0)/G(1) phase arrest and apoptosis in humanleukemia HL-60 cells through inhibiting cyclin D and E, and activating mitochondria-dependent pathway, Anticancer Res., 31, 2821

Veluri, 2006, Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and poptotic death of DU-145 human prostate carcinoma cells, Carcinogenes, 27, 1445, 10.1093/carcin/bgi347

Kamatham, 2015, Isolation and characterization of gallic acid and methylgallate from the seed coats of Givotia rottleriformis Griff. and their anti-proliferative effect on human epidermoidcarcinoma A431 cells, Toxicol. Rep., 2, 520, 10.1016/j.toxrep.2015.03.001

Dodurga, 2016, Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro, Gene, 576, 476, 10.1016/j.gene.2015.10.061

Eitsuka, 2014, Synergistic inhibition of cancer cell proliferation with a combination of delta-tocotrienol and ferulic acid, Biochem. Biophys. Res. Commun., 453, 606, 10.1016/j.bbrc.2014.09.126

Choi, 2015, Ferulic acid in combination with PARP inhibitor sensitizes breast cancer cells as chemotherapeutic strategy, Biochem. Biophys. Res. Commun., 458, 520, 10.1016/j.bbrc.2015.01.147

Janicke, 2011, The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells, Nutr. Cancer, 63, 611, 10.1080/01635581.2011.538486

Fang, 2013, Feruloyl-L-arabinose attenuates migration, invasion and production of reactive oxygen species in H1299 lung cancer cells, Food Chem. Toxicol., 58, 459, 10.1016/j.fct.2013.05.019

Panat, 2016, Troxerutin, a natural flavonoid binds to DNA minor groove and enhances cancer cell killing in response to radiation, Chem. Biol. Interact., 251, 34, 10.1016/j.cbi.2016.03.024

Watanabe, 2007, The chemopreventive flavonoid apigenin confers radiosensitizing effect in human tumor cells grown as monolayers and spheroids, J. Radiat. Res., 48, 45, 10.1269/jrr.0635

Leung, 2007, Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes, Food Chem. Toxicol., 45, 2005, 10.1016/j.fct.2007.04.023

Nirmala, 2011, Effect of myricetin on 1,2 dimethylhydrazineinduced rat colon carcinogenesis, J. Exp. Ther. Oncol., 9, 101

Hsu, 2015, Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry, Antivir. Res., 118, 139, 10.1016/j.antiviral.2015.04.003

Kang, 2008, Inhibitory effect of methyl gallate and gallic acid on oral bacteria, J. Microbiol., 46, 744, 10.1007/s12275-008-0235-7

Choi, 2008, In vitro activity of methyl gallate isolated from galla rhois alone and in combination with ciprofloxacin against clinical isolates of salmonella, J. Microbiol. Biotechnol., 18, 1848

Narasimhan, 2015, Ferulic acid regulates hepatic GLUT2 gene expression in high fat and fructose-induced type-2 diabetic adult male rat, Eur. J. Pharmacol., 761, 391, 10.1016/j.ejphar.2015.04.043

Hou, 2004, Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide, Life Sci., 75, 1775, 10.1016/j.lfs.2004.05.005

Mennen, 2005, Risks and safety of polyphenol consumption, Am. J. Clin. Nutr., 81, 326, 10.1093/ajcn/81.1.326S

Weinreb, 2004, Neurological mechanisms of green tea polyphenols in Alzheimer’s and Parkinson’s diseases, J. Nutr. Biochem., 15, 506, 10.1016/j.jnutbio.2004.05.002

Dai, 2006, Fruit and vegetable juices and Alzheimer’s disease: The Kame project, Am. J. Clin. Nutr., 119, 751

Lin, 2000, Anti-herpes simplex virus type-1 flavonoids and a new flavanone from the root of Limonium sinense, Planta Med., 66, 333, 10.1055/s-2000-8540

Trivedi, 2008, Kaempferol has osteogenic effect in ovariectomized adult Spraguee Dawley rats, Mol. Cell. Endocrinol., 289, 85, 10.1016/j.mce.2008.02.027

Devi, 2015, Kaempferol and inflammation: From chemistry to medicine, Pharmacol. Res., 99, 1, 10.1016/j.phrs.2015.05.002

Filomeni, 2012, Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: Possible implications for Parkinson’s disease, Neurobiol. Aging, 33, 767, 10.1016/j.neurobiolaging.2010.05.021

2011, A review on the dietary flavonoid kaempferol, Mini-Rev. Med. Chem., 11, 298, 10.2174/138955711795305335

Ju, S.M., Kang, J.G., Bae, J.S., Pae, H.O., Lyu, Y.S., and Jeon, B.H. (2015). The flavonoid apigenin ameliorates cisplatin-induced nephrotoxicity through reduction of p53 activation and promotion of PI3K/Akt pathway in human renal proximal tubular epithelial cells. Evid. Based Complement. Altern. Med., 1–9.

Chtourou, 2016, Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat, Chem. Biol. Interact., 243, 1, 10.1016/j.cbi.2015.11.019

Kamel, 2014, Hesperidin and rutin, antioxidant citrus flavonoids, attenuate cisplatin-induced nephrotoxicity in rats, J. Biochem. Mol. Toxic., 28, 312, 10.1002/jbt.21567

Wang, 2013, Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice, Food Chem., 138, 751, 10.1016/j.foodchem.2012.11.106

Pragasam, 2013, Immunomodulatory and anti-inflammatory effect of p-coumaric acid, a common dietary polyphenol on experimental inflammation in rats, Inflammation, 36, 169, 10.1007/s10753-012-9532-8

Chao, 2010, Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice, Mol. Nutr. Food Res., 54, 388, 10.1002/mnfr.200900087

Duma, 2004, Caffeic acid derivatives: In vitro and in vivo anti-inflammatory properties, Free Radic. Res., 38, 1241, 10.1080/10715760400016139

Hamalainen, M., Nieminen, R., Vuorela, P., Heinonen, M., and Moilanen, E. (2007). Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat. Inflamm.

Kane, 1988, Methyl gallate, methyl-3,4,5-trihydoxybenzoate, is a potent and highly specific inhibitor of herpes simplex virus in vitro. II. Antiviral activity of methyl gallate and its derivatives, Biosci. Rep., 8, 95, 10.1007/BF01128976

Cabrera, 2006, Beneficial effects of green tea, J. Am. Coll. Nutr., 25, 79, 10.1080/07315724.2006.10719518

Alvesalo, 2006, Inhibitory effect of dietary phenolic compounds on Chlamydia pneumoniae in cell cultures, Biochem. Pharmacol., 71, 735, 10.1016/j.bcp.2005.12.006

Morinaga, 2005, Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells, J. Biol. Chem., 280, 23303, 10.1074/jbc.M502093200

Mancuso, 2014, Ferulic acid: Pharmacological and toxicological aspects, Food Chem. Toxicol., 65, 185, 10.1016/j.fct.2013.12.024

Yang, 1998, Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model, J. Nutr., 128, 2334, 10.1093/jn/128.12.2334

Tedeschi, 2004, Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1α activation, Mol. Pharmacol., 65, 111, 10.1124/mol.65.1.111

Maeda, 2003, Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier, Atherosclerosis, 166, 23, 10.1016/S0021-9150(02)00302-7

Larson, 2012, Therapeutic potential of quercetin to decrease blood pressure: Review of efficacy and mechanisms, Adv. Nutr., 3, 39, 10.3945/an.111.001271

Villares, 2009, Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease, Inflamm. Res., 58, 537, 10.1007/s00011-009-0037-3

Pirola, 2008, Resveratrol: One molecule, many targets, IUBMB Life, 60, 323, 10.1002/iub.47

Milne, 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, Nature, 450, 712, 10.1038/nature06261

Matsui, 2001, α-Glucosidase inhibitory action of natural acylated anthocyanins, J. Agric. Food Chem., 49, 1952, 10.1021/jf0012502

Smith, 2004, Dietary intake of soy genistein is associated with lung function in patients with asthma, J. Asthma, 41, 833, 10.1081/JAS-200038447

Nakajima, 2001, Suppressive effects of genistein dosage and resistance exercise on bone loss in ovariectomized rats, J. Physiol. Anthropol. Appl. Hum. Sci., 20, 285, 10.2114/jpa.20.285

Sharma, 2009, A thought on the biological activities of black tea, Crit. Rev. Food Sci. Nutr., 49, 379, 10.1080/10408390802068066

Tsuda, 2003, Dietary cyanidin 3-O-β-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice, J. Nutr., 133, 2125, 10.1093/jn/133.7.2125

Seeram, 2003, Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits, J. Agric. Food Chem., 51, 1948, 10.1021/jf025993u

Chung, 1998, Tannins and human health: A review, Crit. Rev. Food Sci. Nutr., 38, 421, 10.1080/10408699891274273

Okuda, 1995, Tannins, a new family of bio-active natural organic compounds questions and answers, J. Pharm. Soc. Jpn., 115, 81, 10.1248/yakushi1947.115.2_81

Liu, 2000, A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women, Am. J. Public Health, 90, 1409, 10.2105/AJPH.90.9.1409

Lloyd, 2000, Effects of commercial processing on antioxidants in rice bran, Cereal Chem., 77, 551, 10.1094/CCHEM.2000.77.5.551

Topping, 2007, Cereal complex carbohydrates and their contribution to human health, J. Cereal Sci., 46, 220, 10.1016/j.jcs.2007.06.004

Chen, 2000, Effects of black and red rice on the formation of aortic plaques and blood lipids in rabbits, J. Hyg. Res., 29, 170

Koide, 1996, Antitumor effect of hydrolyzed anthocyanin from grape rinds and red rice, Cancer Biother. Radiopharm., 11, 273

Kim, 1999, The evaluation of the antianaphylactic effect of Oryza sativa L. subsp. hsien Ting in rats, Pharmacol. Res., 40, 31, 10.1006/phrs.1998.0386

Hu, 1997, A research report on the pharmacologic test of black rice pigment, J. Wuhan Food Ind. Coll., 3, 10

Chandrasekara, 2011, Bioactivities and antiradical properties of millet grains and hulls, J. Agric. Food Chem., 59, 9563, 10.1021/jf201849d

Surendrian, 2013, Wild rice (Zizania paplustris L.) prevents atherogenesis in LDL receptor knockout mice, Atherosclerosis, 230, 284, 10.1016/j.atherosclerosis.2013.07.042

Hsieh, 2005, Alleviation of oxidative damage in multiple tissues in rats with streptozotocin induced diabetes by rice bran oil supplementation, Ann. N. Y. Acad. Sci., 1042, 365, 10.1196/annals.1338.061

Sergent, 2012, Phenolic compounds and plant extracts as potential natural antiobesity substances, Food Chem., 135, 68, 10.1016/j.foodchem.2012.04.074

2016, Identification of phenolic compounds from seed coats of differently colored european varieties of pea (Pisum sativum L.) and characterization of their antioxidant and In vitro anticancer activities, Nutr. Cancer, 68, 988, 10.1080/01635581.2016.1190019

Thompson, 1997, Variability in anticancer lignan levels in flaxseed, Nutr. Cancer, 27, 26, 10.1080/01635589709514497

Sohn, 2014, The anti-inflammatory and antifibrosis effects of anthocyanin extracted from black soybean on a Peyronie disease rat model, Urology, 84, 1112, 10.1016/j.urology.2014.06.026

Zhang, 2014, Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis, Br. J. Nutr., 111, 1549, 10.1017/S0007114513004352

Park, 2011, Red bean extract reduces inflmmation and increases survival murine sepsis model, Food Sci. Biotechnol., 20, 1125, 10.1007/s10068-011-0153-z

Patterson, 2002, Tumour cytochrome P450 and drugactivation, Curr. Pharm. Des., 8, 1335, 10.2174/1381612023394502

Adams, 2006, Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells, J. Agric. Food Chem., 54, 980, 10.1021/jf052005r

Baby, 2017, Antioxidant and anticancer properties of berries, Crit. Rev. Food Sci. Nutr., 13, 1

Bosetti, 2005, Flavonoids and breast cancer risk in Italy, Cancer Epidemiol. Biomark. Prev., 14, 805, 10.1158/1055-9965.EPI-04-0838

Peterson, 2003, Flavonoid intake and breast cancer risk: A case–control study in Greece, Br. J. Cancer, 89, 1255, 10.1038/sj.bjc.6601271

Serra, 2010, Characterization of traditional and exotic apple varieties from Portugal. Part 2-Antioxidant and anti-proliferative activities, J. Funct. Foods, 2, 46, 10.1016/j.jff.2009.12.005

Ha, 2012, Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation, Food Chem. Toxicol., 50, 3498, 10.1016/j.fct.2012.07.007

Cherniack, 2012, A berry thought-provoking idea: The potential role of plant polyphenols in the treatment of age-related cognitive disorders, Br. J. Nutr., 108, 794, 10.1017/S0007114512000669

Gasparrini, 2018, Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast, Food Chem. Toxicol., 114, 128, 10.1016/j.fct.2018.02.038

Visioli, 2012, Polyphenols and health: Moving beyond antioxidants, J. Berry Res., 2, 63, 10.3233/JBR-2012-028

Zhou, Y., Zheng, J., Li, Y., Xu, D.P., Li, S., Chen, U.M., and Li, H.B. (2016). Natural polyphenols for prevention and treatment of cancer. Nutrients, 8.