Beyond HPV: Oncomirs as new players in cervical cancer
Tóm tắt
MicroRNAs (miRNAs) are a recently discovered family of 18–24 nucleotide non‐coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer‐relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer.
Tài liệu tham khảo
10.1016/S0092-8674(04)00045-5
10.1126/science.1065329
10.1101/gad.1291905
10.1126/science.1064921
10.1038/ng1590
10.1016/j.cell.2004.12.031
10.1016/S0092-8674(03)00231-9
10.1016/S0092-8674(04)00045-5
10.1158/1078-0432.CCR-07-1231
10.1158/0008-5472.CAN-05-1783
10.1073/pnas.0511155103
10.1158/0008-5472.CAN-05-2352
10.1073/pnas.0404432101
10.1038/nature03702
10.1016/j.ccr.2007.07.027
10.1073/pnas.0307323101
10.1002/ijc.1440
10.1093/oxfordjournals.jncimonographs.a003479
10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
10.1093/jnci/djj067
10.1016/0092-8674(90)90409-8
10.1126/science.2537532
Boyer S.N., 1996, E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway, Cancer Res., 56, 4620
Xiaohong Wang, 2008, Aberrant expression of oncogenic and tumor-suppressive MicroRNAs in cervical cancer is required for cancer cell growth, PLoS ONE, 3, 7
10.1159/000113489
10.1111/j.1349-7006.2007.00618.x
10.1158/0008-5472.CAN-06-0561
10.1038/sj.onc.1210919
10.1073/pnas.0605298103
10.1128/JVI.02136-07
10.4161/rna.4.3.5206
10.1261/rna.874808
10.1073/pnas.0509603102
10.1038/ng1793
10.1126/science.1096781
10.1038/nmeth746
10.1073/pnas.0408192102
10.1128/JVI.79.14.9301-9305.2005
10.1038/nature04836
10.1128/JVI.00200-06
10.1038/nature03576
10.1038/nrc1997
10.1038/nature03552
10.1016/j.cell.2006.02.037
10.1073/pnas.0510565103
10.1073/pnas.0506654102
10.1073/pnas.0602266103
10.1016/j.cell.2004.12.038
10.1056/NEJMoa050995
10.1016/j.ccr.2006.01.025
10.1074/jbc.M601496200
10.1016/j.cell.2005.09.023
10.1038/nature03702
10.1261/rna.7240905
10.1053/j.seminoncol.2006.01.010
10.1200/JCO.2005.05.5194
10.1038/nature04303