Benzodiazepine Receptor: Demonstration in the Central Nervous System

American Association for the Advancement of Science (AAAS) - Tập 198 Số 4319 - Trang 849-851 - 1977
H Möhler1, Toshikazu Okada1
1Pharmaceutical Research Department, F. Hoffmann-La Roche, 4002 Basle, Switzerland

Tóm tắt

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.

Từ khóa


Tài liệu tham khảo

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