William G. Iacono1, Scott R. Carlson1, Jeanette Taylor1, Irene J. Elkins1, Matt McGue1
1Department of Psychology, University of Minnesota
Tóm tắt
One variant of substance-use disorder is characterized by behavioral disinhibition. In this
report, we martial evidence for a model for the development of this variant. We hypothesize that
genetic liability for this variant is reflected in a spectrum of risk indicators linked to the inability
or unwillingness to inhibit behavioral impulses. Included in this spectrum are personality traits
suggesting low constraint, and externalizing psychopathology, including conduct, oppositional
defiant, and attention-deficit disorder in children and antisocial personality disorder and behavior
in adults. We further hypothesize that these individual differences in behavioral disinhibition are
manifestations of underlying central nervous system processes associated with various
psychophysiological anomalies, some of which may index genetic risk for substance abuse.
Support for the model is derived from the analysis of findings from the Minnesota Twin Family
Study, an epidemiological investigation of approximately 2,700 adolescent twins and their
parents.