Bats Are Natural Reservoirs of SARS-Like Coronaviruses

American Association for the Advancement of Science (AAAS) - Tập 310 Số 5748 - Trang 676-679 - 2005
Wendong Li1,2,3,4,5, Zheng‐Li Shi1,2,4,5, Meng Yu1,2,3,5, Wuze Ren1,2,4,5, John Bingham1,2,3,4,5, Jonathan H. Epstein1,2,3,4,5, Sheng Wang1,2,4,5, Gary Crameri1,2,3,5, Zhìhóng Hú1,2,4,5, Huajun Zhang1,2,4,5, Jianhong Zhang1,2,4,5, Jennifer Barr1,2,3,5, Hume Field1,2,3,4,5, Peter Daszak1,2,3,4,5, Bryan T. Eaton1,2,3,5, Shuyi Zhang1,2,3,4,5, Lin‐Fa Wang1,2,3,5
1Commonwealth Scientific and Industrial Research Organization (CSIRO) Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia.
2Department of Primary Industries and Fisheries, Queensland, Australia
3Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China
4State Key Laboratory of Virology, Wuhan Institute of Virology CAS, Wuhan, China
5The Consortium for Conservation Medicine, New York, USA

Tóm tắt

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.

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This work was jointly funded by a special grant for “Animal Reservoir of SARS-CoV ” State Key Program for Basic Research Grant 2005CB523004 and State High Technology Development Program grant no. 2005AA219070 from the Ministry of Science and Technology People's Republic of China; the Sixth Framework Program “EPISARS” from the European Commission (no. 51163); the Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease (Project 1.007R); and an NIH/NSF “Ecology of Infectious Diseases” award (no. R01-TW05869) from the John E. Fogarty International Center and the V. Kann Rasmussen Foundation. For the full-length genome sequence of SL-CoV Rp3 see GenBank accession no. DQ71615. Additional GenBank accession numbers are given in the supporting material.

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American Association for the Advancement of Science (AAAS)

Tập 310 Số 5748

676-679

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