Các đột biến BRIP1, RAD51C và RAD51D liên quan đến độ nhạy cảm cao với ung thư buồng trứng: tần suất đột biến và ước lượng rủi ro chính xác dựa trên phân tích tổng hợp khoảng 30,000 ca
Tóm tắt
Ước tính rằng hơn 20% trường hợp ung thư buồng trứng có liên quan đến yếu tố di truyền mà chỉ được giải thích một phần bởi các đột biến dòng sinh giao tử trong các gen
Phân tích cho phép ước lượng chính xác các nguy cơ ung thư buồng trứng liên quan đến các đột biến trong
Phân tích tổng hợp cung cấp bằng chứng hỗ trợ cho tính gây bệnh của các đột biến
Từ khóa
#ung thư buồng trứng #gen BRIP1 #RAD51C #RAD51D #đột biến di truyền #nguy cơ ung thưTài liệu tham khảo
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