Autophagy in Chronic Kidney Diseases

Decuypere, 2016, Autophagy in renal diseases, Pediatr. Nephrol., 31, 737, 10.1007/s00467-015-3134-2

Parzych, 2014, An overview of autophagy: Morphology, mechanism, and regulation, Antioxid. Redox Signal., 20, 460, 10.1089/ars.2013.5371

Wang, 2014, Autophagy in kidney health and disease, Antioxid. Redox Signal., 20, 519, 10.1089/ars.2013.5363

Ohsumi, 2014, Historical landmarks of autophagy research, Cell. Res., 24, 9, 10.1038/cr.2013.169

Choi, 2013, Autophagy in human health and disease, N. Engl. J. Med., 368, 651, 10.1056/NEJMra1205406

Takeshige, 1992, Autophagy in Yeast Demonstrated with Proteinase-deficient Mutants and Conditions for its Induction, J. Cell Biol., 119, 301, 10.1083/jcb.119.2.301

Cheng, 2013, Therapeutic targeting of autophagy in disease: Biology and pharmacology, Pharmacol. Rev., 65, 1162, 10.1124/pr.112.007120

Guan, 2015, Autophagy protects renal tubular cells against ischemia/reperfusion injury in a time-dependent manner, Cell. Physiol. Biochem., 36, 285, 10.1159/000374071

Duann, P., Lianos, E.A., Ma, J., and Lin, P.H. (2016). Autophagy, Innate Immunity and Tissue Repair in Acute Kidney Injury. Int. J. Mol. Sci., 17.

Shintani, 2004, Autophagy in health and disease: A double-edged sword, Science, 306, 990, 10.1126/science.1099993

Mehrpour, 2010, Autophagy in health and disease. 1. Regulation and significance of autophagy: An overview, Am. J. Physiol. Cell Physiol., 298, C776, 10.1152/ajpcell.00507.2009

Lenoir, 2016, Autophagy in kidney disease and aging: Lessons from rodent models, Kidney Int., 90, 950, 10.1016/j.kint.2016.04.014

He, 2014, Autophagy in acute kidney injury and repair, Nephron Clin. Pract., 127, 56, 10.1159/000363677

Hartleben, 2010, Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice, J. Clin. Investig., 120, 1084, 10.1172/JCI39492

Angoorani, 2016, Dietary consumption of advanced glycation end products and risk of metabolic syndrome, Int. J. Food Sci. Nutr., 67, 170, 10.3109/09637486.2015.1137889

Chiang, 2016, Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury, Sci. Rep., 6, 34167, 10.1038/srep34167

Hou, 2014, Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway, Cardiovasc. Diabetol., 13, 78, 10.1186/1475-2840-13-78

Wang, 2008, Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway, Cell. Mol. Life Sci., 65, 3640, 10.1007/s00018-008-8383-9

Nagata, 2016, Podocyte injury and its consequences, Kidney Int., 89, 1221, 10.1016/j.kint.2016.01.012

Decuypere, 2015, Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy, Am. J. Kidney Dis., 66, 699, 10.1053/j.ajkd.2015.05.021

Kreidberg, 2013, Podocyte Differentiation and Glomerulogenesis, J. Am. Soc. Nephrol., 14, 806, 10.1097/01.ASN.0000054887.42550.14

Wharram, 2005, Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene, J. Am. Soc. Nephrol., 16, 2941, 10.1681/ASN.2005010055

Sato, 2009, Correlation of Autophagy Type in Podocytes with Histopathological Diagnosis of IgA Nephropathy, Pathobiology, 76, 221, 10.1159/000228897

Andrade, 2018, Acute Kidney Injury as a Condition of Renal Senescence, Cell Transplant., 27, 739, 10.1177/0963689717743512

Cina, 2012, Inhibition of MTOR disrupts autophagic flux in podocytes, J. Am. Soc. Nephrol., 23, 412, 10.1681/ASN.2011070690

Stallone, 2011, Sirolimus and proteinuria in renal transplant patients: Evidence for a dose-dependent effect on slit diaphragm-associated proteins, Transplantation, 91, 997, 10.1097/TP.0b013e318211d342

Lin, 2017, Autophagy in renal tubular injury and repair, Acta Physiol., 220, 229, 10.1111/apha.12852

Liu, 2012, Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury, Autophagy, 8, 826, 10.4161/auto.19419

Li, 2013, New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy, J. Am. Soc. Nephrol., 25, 305, 10.1681/ASN.2013040374

Kimura, 2011, Autophagy protects the proximal tubule from degeneration and acute ischemic injury, J. Am. Soc. Nephrol., 22, 902, 10.1681/ASN.2010070705

Jiang, 2012, Autophagy in proximal tubules protects against acute kidney injury, Kidney Int., 82, 1271, 10.1038/ki.2012.261

He, 2017, AKI on CKD: Heightened injury, suppressed repair, and the underlying mechanisms, Kidney Int., 92, 1071, 10.1016/j.kint.2017.06.030

Sureshbabu, 2015, Oxidative stress and autophagy: Crucial modulators of kidney injury, Redox Biol., 4, 208, 10.1016/j.redox.2015.01.001

Eltzschig, 2011, Ischemia and reperfusion--from mechanism to translation, Nat. Med., 17, 1391, 10.1038/nm.2507

Raedschelders, 2012, The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion, Pharmacol. Ther., 133, 230, 10.1016/j.pharmthera.2011.11.004

Martin, J.L., Gruszczyk, A.V., Beach, T.E., Murphy, M.P., and Saeb-Parsy, K. (2018). Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury. Pediatr. Nephrol., 1–8.

Melk, 2016, The yin and yang of autophagy in acute kidney injury, Autophagy, 12, 596, 10.1080/15548627.2015.1135284

Wang, 2012, ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy, Autophagy, 8, 1462, 10.4161/auto.21211

Jiang, 2010, Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury, Am. J. Pathol., 176, 1181, 10.2353/ajpath.2010.090594

Kimura, 2013, Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress, Autophagy, 9, 1876, 10.4161/auto.25418

Kaushal, 2016, Autophagy in acute kidney injury, Kidney Int., 89, 779, 10.1016/j.kint.2015.11.021

Coresh, 2005, Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000, J. Am. Soc. Nephrol., 16, 180, 10.1681/ASN.2004070539

Hill, N.R., Fatoba, S.T., Oke, J.L., Hirst, J.A., O’Callaghan, C.A., Lasserson, D.S., and Hobbs, F.D. (2016). Global Prevalence of Chronic Kidney Disease—A Systematic Review and Meta-Analysis. PLoS ONE, 11.

Levey, 2012, Chronic kidney disease, Lancet, 379, 165, 10.1016/S0140-6736(11)60178-5

Song, 2018, Activation of autophagy contributes to the renoprotective effect of postconditioning on acute kidney injury and renal fibrosis, Biochem. Biophys. Res. Commun., 504, 641, 10.1016/j.bbrc.2018.09.003

Leventhal, 2017, Recycling to discover something new: The role of autophagy in kidney disease, Kidney Int., 91, 4, 10.1016/j.kint.2016.11.004

Lenoir, 2015, Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis, Autophagy, 11, 1130, 10.1080/15548627.2015.1049799

Chen, 2013, Impaired leukocytes autophagy in chronic kidney disease patients, Cardiorenal Med., 3, 254, 10.1159/000356212

Klionsky, 2016, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy, 12, 1, 10.1080/15548627.2015.1100356

Blume, 2011, Left atrial function: Physiology, assessment, and clinical implications, Eur. J. Echocardiogr., 12, 421, 10.1093/ejechocard/jeq175

Dai, 2017, Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy, J. Diabetes Res., 2017, 2615286, 10.1155/2017/2615286

Liu, 2017, Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy, J. Diabetes Res., 2017, 3560238, 10.1155/2017/3560238

Ma, 2013, High glucose induces autophagy in podocytes, Exp. Cell. Res., 319, 779, 10.1016/j.yexcr.2013.01.018

Kume, 2015, Emerging role of podocyte autophagy in the progression of diabetic nephropathy, Autophagy, 11, 2385, 10.1080/15548627.2015.1115173

Ding, 2015, Autophagy in diabetic nephropathy, J. Endocrinol., 224, R15, 10.1530/JOE-14-0437

Susztak, 2006, Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy, Diabetes, 55, 225, 10.2337/diabetes.55.01.06.db05-0894

Xin, 2016, Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance, Metabolism, 65, 1307, 10.1016/j.metabol.2016.05.015

Tagawa, 2016, Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy, Diabetes, 65, 755, 10.2337/db15-0473

Kitada, 2011, Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: A model of type 2 diabetes, Exp. Diabetes Res., 2011, 908185, 10.1155/2011/908185

Kitada, 2017, Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy, Curr. Diabetes Rep., 17, 53, 10.1007/s11892-017-0879-y

Yamahara, 2013, Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions, J. Am. Soc. Nephrol., 24, 1769, 10.1681/ASN.2012111080

Martinez, 2016, Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells, Nature, 533, 115, 10.1038/nature17950

Zhou, 2012, Autophagy in immunity: Implications in etiology of autoimmune/autoinflammatory diseases, Autophagy, 8, 1286, 10.4161/auto.21212

Bonam, 2018, Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option, J. Autoimmun., 94, 16, 10.1016/j.jaut.2018.08.009

Maroz, 2013, Lupus Nephritis and End-stage Kidney Disease, Am. J. Med. Sci., 346, 319, 10.1097/MAJ.0b013e31827f4ee3

Kimura, 2017, Autophagy and kidney inflammation, Autophagy, 13, 997, 10.1080/15548627.2017.1309485

Leung, 2010, Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display, Proc. Natl. Acad. Sci. USA, 107, 2165, 10.1073/pnas.0909448107

Lee, 2008, The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy, Oncogene, 27, 2833, 10.1038/sj.onc.1210946

Leventhal, 2016, LAPping up dead cells to prevent lupus nephritis: A novel role for noncanonical autophagy in autoimmunity, Kidney Int., 90, 238, 10.1016/j.kint.2016.06.001

Jin, 2018, The novel involvement of podocyte autophagic activity in the pathogenesis of lupus nephritis, Histol. Histopathol., 33, 803

Wang, 2015, The Role of Autophagy in Lupus Nephritis, Int. J. Mol. Sci., 16, 25154, 10.3390/ijms161025154

Ren, 2017, Autophagy: A Potential Therapeutic Target for Reversing Sepsis-Induced Immunosuppression, Front. Immunol., 8, 1832, 10.3389/fimmu.2017.01832

Hsiao, 2012, The decline of autophagy contributes to proximal tubular dysfunction during sepsis, Shock, 37, 289, 10.1097/SHK.0b013e318240b52a

Li, 2010, Autophagy is a component of epithelial cell fate in obstructive uropathy, Am. J. Pathol., 176, 1767, 10.2353/ajpath.2010.090345

Ding, 2014, Autophagy Regulates TGF- Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction, J. Am. Soc. Nephrol., 25, 2835, 10.1681/ASN.2013101068

Livingston, 2016, Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction, Autophagy, 12, 976, 10.1080/15548627.2016.1166317

Lei, 2018, Mitophagy Plays a Protective Role in Iodinated Contrast-Induced Acute Renal Tubular Epithelial Cells Injury, Cell. Physiol. Biochem., 46, 975, 10.1159/000488827

Yang, 2008, Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells, Am. J. Physiol. Renal Physiol., 294, F777, 10.1152/ajprenal.00590.2007

Inoue, 2010, Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo, Clin. Exp. Nephrol., 14, 112, 10.1007/s10157-009-0254-7

Ning, 2018, Necrostatin-1 Attenuates Cisplatin-Induced Nephrotoxicity Through Suppression of Apoptosis and Oxidative Stress and Retains Klotho Expression, Front. Pharmacol., 9, 384, 10.3389/fphar.2018.00384

Liu, 2018, Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells, Cell Death Dis., 9, 322, 10.1038/s41419-018-0374-7

Takahashi, 2012, Autophagy guards against cisplatin-induced acute kidney injury, Am. J. Pathol., 180, 517, 10.1016/j.ajpath.2011.11.001

Li, 2016, Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKalpha-regulated Autophagy Induction, Sci. Rep., 6, 23975, 10.1038/srep23975

Yi, 2017, Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy, Am. J. Physiol. Renal Physiol., 313, F74, 10.1152/ajprenal.00114.2017

Asanuma, 2003, MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis, FASEB J., 17, 1165, 10.1096/fj.02-0580fje

Kang, 2014, The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes, Biochem. Biophys. Res. Commun., 443, 628, 10.1016/j.bbrc.2013.12.015

Zeng, 2014, Podocyte autophagic activity plays a protective role in renal injury and delays the progression of podocytopathies, J. Pathol., 234, 203, 10.1002/path.4382

Peintner, 2017, Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD), Cell Tissue Res., 369, 27, 10.1007/s00441-017-2628-6

Ravichandran, 2014, Polycystic kidney disease: A case of suppressed autophagy?, Semin. Nephrol., 34, 27, 10.1016/j.semnephrol.2013.11.005

Distefano, 2009, Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1, Mol. Cell. Biol., 29, 2359, 10.1128/MCB.01259-08

Chang, 2017, Targeting new cellular disease pathways in autosomal dominant polycystic kidney disease, Nephrol. Dial. Transplant., 33, 1310, 10.1093/ndt/gfx262

Rowe, 2013, Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy, Nat. Med., 19, 488, 10.1038/nm.3092

Cebotaru, 2014, Polycystin-1 Negatively Regulates Polycystin-2 Expression via the Aggresome/Autophagosome Pathway, J. Biol. Chem., 289, 6404, 10.1074/jbc.M113.501205

Zhu, 2017, Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model, Hum. Mol. Genet., 26, 158

Nyengaard, 1992, Glomerular number and size in relation to age, kidney weight, and body surface in normal man, Anat. Rec., 232, 194, 10.1002/ar.1092320205

Wang, 2014, The aging kidney: Increased susceptibility to nephrotoxicity, Int. J. Mol. Sci., 15, 15358, 10.3390/ijms150915358

Minutolo, 2012, The effect of increasing age on the prognosis of non-dialysis patients with chronic kidney disease receiving stable nephrology care, Kidney Int., 82, 482, 10.1038/ki.2012.174

Nitta, 2013, Aging and chronic kidney disease, Kidney Blood Press Res., 38, 109, 10.1159/000355760

Yamamoto, 2016, Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule, Autophagy, 12, 801, 10.1080/15548627.2016.1159376

Schmitt, 2017, Molecular mechanisms of renal aging, Kidney Int., 92, 569, 10.1016/j.kint.2017.02.036

Boutouja, F., Stiehm, C.M., and Platta, H.W. (2019). mTOR: A cellular regulator interface in health and disease. Cells, 8.

Jankauskas, 2018, Aged kidney: Can we protect it? Autophagy, mitochondria and mechanisms of ischemic preconditioning, Cell Cycle, 17, 1291, 10.1080/15384101.2018.1482149

Andrianova, N.V., Jankauskas, S.S., Zorova, L.D., Pevzner, I.B., Popkov, V.A., Silachev, D.N., Plotnikov, E.Y., and Zorov, D.B. (2018). Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury. Cells, 7.

Yu, 2010, Termination of autophagy and reformation of lysosomes regulated by mTOR, Nature, 465, 942, 10.1038/nature09076

Wu, 2018, Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis, J. Cell. Mol. Med., 22, 1190, 10.1111/jcmm.13393

Wang, 2016, Activation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis, Cell Death Dis., 7, 2290, 10.1038/cddis.2016.79

Bizargity, 2014, Autophagy: Basic principles and relevance to transplant immunity, Am. J. Transplant., 14, 1731, 10.1111/ajt.12743

Nakagawa, 2012, Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury, Eur. J. Pharmacol, 696, 143, 10.1016/j.ejphar.2012.09.010

Secoli, 2014, Influence of cyclosporine on the occurrence of nephrotoxicity after allogeneic hematopoietic stem cell transplantation: A systematic review, Revista Brasileira de Hematologia e Hemoterapia, 36, 363, 10.1016/j.bjhh.2014.03.010

Lim, 2012, Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance, Transplantation, 94, 218, 10.1097/TP.0b013e31825ace5c

Wu, 2018, Mechanism of cyclosporine A nephrotoxicity: Oxidative stress, autophagy, and signalings, Food Chem. Toxicol., 118, 889, 10.1016/j.fct.2018.06.054

Schroppel, 2014, Delayed kidney graft function: From mechanism to translation, Kidney Int., 86, 251, 10.1038/ki.2014.18

Rubinsztein, 2012, Autophagy modulation as a potential therapeutic target for diverse diseases, Nat. Rev. Drug Discov., 11, 709, 10.1038/nrd3802

Giampieri, 2019, Autophagy in Human Health and Disease: Novel Therapeutic Opportunities, Antioxid. Redox Signal., 30, 577, 10.1089/ars.2017.7234

Shivakumar, 2018, Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux, Biomed. Res. Int., 2018, 7627329, 10.1155/2018/7627329

Bullon, P., Cordero, M.D., Quiles, J.L., Ramirez-Tortosa, M.D.C., Gonzalez-Alonso, A., Alfonsi, S., García-Marín, R., de Miguel, M., and Battino, M. (2012). Autophagy in periodontitis patients and gingival fibroblasts: Unraveling the link between chronic diseases and inflammation. BMC Med., 10.