Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective

Electrophoresis - Tập 30 Số S1 - 2009
Nicolas Guex1,2, Manuel C. Peitsch1,3,2, Torsten Schwede4,5
1Authors appear in alphabetical order
2Swiss Institute of Bioinformatics, Lausanne, Switzerland
3Philip Morris International, Research and Development, Neuchâtel, Switzerland
4Biozentrum, University of Basel, Switzerland
5Swiss Institute of Bioinformatics, Basel, Switzerland

Tóm tắt

AbstractSWISS‐MODEL pioneered the field of automated modeling as the first protein modeling service on the Internet. In combination with the visualization tool Swiss‐PdbViewer, the Internet‐based Workspace and the SWISS‐MODEL Repository, it provides a fully integrated sequence to structure analysis and modeling platform. This computational environment is made freely available to the scientific community with the aim to hide the computational complexity of structural bioinformatics and encourage bench scientists to make use of the ever‐increasing structural information available. Indeed, over the last decade, the availability of structural information has significantly increased for many organisms as a direct consequence of the complementary nature of comparative protein modeling and experimental structure determination. This has a very positive and enabling impact on many different applications in biomedical research as described in this paper.

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Electrophoresis

Tập 30 Số S1

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