Atypical age‐dependent effects of autism on white matter microstructure in children of 2–7 years

Human Brain Mapping - Tập 37 Số 2 - Trang 819-832 - 2016
Minhui Ouyang1,2,3, Hua Cheng4, Virendra Mishra1, Gaolang Gong5, Matthew W. Mosconi6,7, John A. Sweeney6,7, Yun Peng4, Hao Huang1,3,8
1Advanced Imaging Research Center University of Texas Southwestern Medical Center Texas
2Biomedical Engineering Joint Graduate Program University of Texas at Arlington‐University of Texas Southwestern Medical Center Texas
3Department of Radiology, Children's Hospital of Philadelphia, Pennsylvania
4Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, China
5State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
6Center for Autism and Developmental Disabilities University of Texas Southwestern Medical Center Dallas Texas
7Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas
8Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania

Tóm tắt

AbstractAtypical age‐dependent changes of white matter (WM) microstructure play a central role in abnormal brain maturation of the children with autism spectrum disorder (ASD), but their early manifestations have not been systematically characterized. The entire brain core WM voxels were surveyed to detect differences in WM microstructural development between 31 children with ASD of 2–7 years and 19 age‐matched children with typical development (TD), using measurements of fractional anisotropy (FA) and radial diffusivity (RD) from diffusion tensor imaging (DTI). The anatomical locations, distribution, and extent of the core WM voxels with atypical age‐dependent changes in a specific tract or tract group were delineated and evaluated by integrating the skeletonized WM with a digital atlas. Exclusively, unidirectional FA increases and RD decreases in widespread WM tracts were revealed in children with ASD before 4 years, with bi‐directional changes found for children with ASD of 2–7 years. Compared to progressive development that raised FA and lowered RD during 2–7 years in the TD group, flattened curves of WM maturation were found in multiple major WM tracts of all five tract groups, particularly associational and limbic tracts, in the ASD group with trend lines of ASD and TD crossed around 4 years. We found atypical age‐dependent changes of FA and RD widely and heterogeneously distributed in WM tracts of children with ASD. The early higher WM microstructural integrity before 4 years reflects abnormal neural patterning, connectivity, and pruning that may contribute to aberrant behavioral and cognitive development in ASD. Hum Brain Mapp 37:819–832, 2016. © 2015 Wiley Periodicals, Inc.

Từ khóa


Tài liệu tham khảo

10.1016/j.neuroimage.2006.08.032

Allen G, 2005, The cerebellum in autism, Clin Neuropsychiatry, 2, 321

10.1016/j.tins.2007.12.005

APA, 2000, Diagnostic and Statistical Manual of Mental Disorders

10.1136/bmj.327.7413.488

10.1093/cercor/bhi062

10.1016/S0006-3495(94)80775-1

Bauman M, 1987, Limbic involvement in a second case of early infantile autism, Neurology, 37, 147

10.1002/nbm.782

10.1016/j.neuroimage.2007.04.060

10.1016/j.tics.2005.01.011

10.1016/j.cortex.2008.05.004

10.1016/j.neuroimage.2010.01.011

10.1111/j.1469-8749.1969.tb01461.x

10.1016/j.neuron.2007.10.016

10.1177/1362361313480277

10.1037/0012-1649.40.2.271

10.1176/appi.ajp.157.12.1994

10.1002/hbm.21334

10.1016/j.neurobiolaging.2011.06.027

10.1038/npp.2012.133

10.1016/j.cmpb.2005.08.004

Kanner L, 1968, Autistic disturbances of affective contact, Acta Paedopsychiatr, 35, 100

10.1016/j.neuroimage.2011.01.007

10.1111/j.1469-7610.1980.tb01797.x

10.1093/cercor/bhp278

10.1523/JNEUROSCI.5302-10.2011

10.1007/BF02172145

10.1016/j.mri.2008.01.047

10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3

10.1016/j.neuroimage.2007.12.035

10.1523/JNEUROSCI.2731-14.2015

10.1038/nrn2513

10.1016/j.cell.2011.08.040

10.1017/S0033291710002187

10.1109/42.796284

10.1016/j.cortex.2008.04.004

10.1016/j.neuropsychologia.2011.02.022

10.1016/j.neuroimage.2006.02.024

10.1016/j.neuroimage.2008.03.061

10.1016/j.neuroimage.2005.01.028

10.1176/appi.ajp.2012.12030397

10.1093/cercor/bhn031

10.1002/aur.1243

10.1016/j.neuroimage.2007.02.049

10.1148/radiol.2301021640

10.1016/j.biopsych.2012.08.001

10.1002/hbm.21042

10.1002/mrm.21965

10.1176/appi.ajp.2011.11091447

10.1097/00004728-199801000-00027

10.1073/pnas.0705803104

Thông tin
Thông tin xuất bản

Human Brain Mapping

Tập 37 Số 2

819-832

Thông tin tác giả