Attenuation of an adult T-cell leukemia skin lesion after treatment of a concomitant herpes simplex infection: a case study

Virology Journal - Tập 9 - Trang 1-4 - 2012
Hajime Tomita1, Fumihide Ogawa1, Sayaka Kuwatsuka1, Fumi Toriyama2, Shinichirou Yasumoto3, Shimeru Kamihira4, Atsushi Utani1
1Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
2Department of Dermatology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan
3Department of Dermatology, Kurume University School of Medicine, Kurume, Japan
4Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Tóm tắt

We report the development and treatment of eczema herpeticum in a 51-year-old male suffering from adult T-cell leukemia (ATL). Lesions of eczema herpeticum coexisted with the skin lesions of ATL. Treatment of eczema herpeticum resulted in a concomitant improvement in the symptoms of ATL, including a reduction in the size of the ATL plaques, for over 2 months before relapse.

Tài liệu tham khảo

Santmyire-Rosenberger BR, Nigra TP: Psoriasis herpeticum: three cases of Kaposi’s varicelliform eruption in psoriasis. J. Am. Acad. Dermatol. 2005, 53: 52-56. 10.1016/j.jaad.2005.01.140. Toulza F, Heaps A, Tanaka Y, Taylor GP, Bangham CR: High frequency of CD4 + FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response. Blood. 2008, 111: 5047-5053. 10.1182/blood-2007-10-118539. Rouse BT, Suvas S: Regulatory cells and infectious agents: detentes cordiale and contraire. J Immunol. 2004, 173: 2211-2215. Fernandez MA, Puttur FK, Wang YM, Howden W, Alexander SI, Jones CA: T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. J Immunol. 2008, 180: 1556-1564. Li-Weber M, Giaisi M, Chlichlia K, Khazaie K, Krammer PH: Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells. Eur J Immunol. 2001, 31: 2623-2632. 10.1002/1521-4141(200109)31:9<2623::AID-IMMU2623>3.0.CO;2-4. Howell MD, Wollenberg A, Gallo RL, Flaig M, Streib JE, Wong C, Pavicic T, Boguniewicz M, Leung DY: Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol. 2006, 117: 836-841. 10.1016/j.jaci.2005.12.1345. Dodon MD, Li Z, Hamaia S, Gazzolo L: Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J Gen Virol. 2004, 85: 1921-1932. 10.1099/vir.0.79921-0. Kawakami Y, Tomimori Y, Yumoto K, Hasegawa S, Ando T, Tagaya Y, Crotty S, Kawakami T: Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J Exp Med. 2009, 206: 1219-1225. 10.1084/jem.20082835. Whittaker SJ, Foss FM: Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma. Cancer Treat Rev. 2007, 33: 146-160. 10.1016/j.ctrv.2006.08.006. Suryawanshi A, Veiga-Parga T, Rajasagi NK, Reddy PB, Sehrawat S, Sharma S, Rouse BT: Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. J Immunol. 2011, 187: 1919-30. 10.4049/jimmunol.1100736.