Attenuation of Urinary Cadmium in Inhabitants of the Environmentally Exposed Jinzu River Basin Determined by Applying a Mixed Linear Model

Springer Science and Business Media LLC - Tập 96 - Trang 699-703 - 2016
Kazuhiro Nogawa1, Yasushi Suwazono1, Masao Ishizaki2, Keiko Aoshima3, Rie Okamoto4, Muneko Nishijo5, Hideaki Nakagawa5, Teruhiko Kido4
1Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
2Department of Social and Environmental Medicine, Kanazawa Medical University, Ishikawa, Japan
3Hagino Hospital, Toyama, Japan
4Department of Community Health Nursing, Kanazawa University School of Health Sciences, Ishikawa, Japan
5Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan

Tóm tắt

Half-life of urinary cadmium level (U-Cd) was estimated in inhabitants whose initial U-Cd was ≥5 μg/L (131 men and 177 women) or ≥5 μg/gcr (195 men and 246 women), using a linear mixed model adjusted for the baseline age. To clarify the effect of initial U-Cd, the target participants were divided into higher or lower initial U-Cd group. In the higher groups, the half-lives were 15.4 and 13.1 years for unadjusted U-Cd and 19.0 and 23.0 years for creatinine-adjusted U-Cd, in men and women, respectively. In the lower groups, the half-lives were 38.0 and 26.0 years for unadjusted U-Cd in men and women. For creatinine-adjusted U-Cd, it was 42.9 years in men. For attenuation of U-Cd, there were an early fast component shown in the higher group and late slow component shown in the lower group. The attenuation of U-Cd is slower in the longer time compared to that previously reported.

Tài liệu tham khảo

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