Astrocyte-induced modulation of synaptic transmission

Canadian Journal of Physiology and Pharmacology - Tập 77 Số 9 - Trang 699-706 - 1999
Alfonso Araque1, Rita P. Sanzgiri2, Vladimir Parpura2, Philip G. Haydon2
1Department of Zoology and Genetics, Iowa State University, Ames 50011, USA.
2Iowa State University

Tóm tắt

The idea that astrocytes simply provide structural and trophic support to neurons has been challenged by recent evidence demonstrating that astrocytes exhibit a form of excitability and communication based on intracellular Ca2+ variations and intercellular Ca2+ waves, which can be initiated by neuronal activity. These astrocyte Ca2+ variations have now been shown to induce glutamate-dependent Ca2+ elevations and slow inward currents in neurons. More recently, it has been demonstrated that synaptic transmission between cultured hippocampal neurons can be directly modulated by astrocytes. We have reported that astrocyte stimulation can increase the frequency of miniature synaptic currents. Furthermore, we also have demonstrated that an elevation in the intracellular Ca2+ in astrocytes induces a reduction in both excitatory and inhibitory evoked synaptic transmission through the activation of selective presynaptic metabotropic glutamate receptors.Key words: astrocyte-neuron signaling, glutamate receptors, calcium waves, neuronal electrical activity, synaptic transmission.

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Thông tin xuất bản

Canadian Journal of Physiology and Pharmacology

Tập 77 Số 9

699-706

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