Mối liên hệ giữa sự tiếp xúc với Asen và các biến đổi toàn cầu của histone sau phiên mã ở người lớn tại Bangladesh

Cancer Epidemiology Biomarkers and Prevention - Tập 21 Số 12 - Trang 2252-2260 - 2012
Yana Chervona1,2,3, Megan N. Hall1,2,3, Adriana Arita1,2,3, Fen Wu1,2,3, Hong Sun1,2,3, Hsiang-Chi Tseng1,2,3, Eunüs S. Ali1,2,3, Mohammad Nasir Uddin1,2,3, Xinhua Liu1,2,3, Maria Antonietta Zoroddu1,2,3, Mary V. Gamble1,2,3, Max Costa1,2,3
1Authors' Affiliations: 1Department of Environmental Medicine, New York University School of Medicine; 2Columbia University Arsenic Project in Bangladesh; 3Departments of Epidemiology, 4Biostatistics, and 5Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York; and 6Department of Chemistry, University of Sassari, Sassari, Italy
2Columbia University Arsenic Project in Bangladesh
3Department of Chemistry, University of Sassari, Sassari, Italy

Tóm tắt

Tóm tắtNền tảng: Sự tiếp xúc với asen (As) có liên quan đến nguy cơ gia tăng của nhiều loại ung thư cũng như các bệnh tim mạch, và các sự thiếu hụt phát triển thần kinh ở trẻ em. Các hợp chất asen có tính đột biến yếu, làm thay đổi biểu hiện gen và các biến đổi histone sau phiên mã (PTHMs) in vitro.Phương pháp: Nồng độ As trong nước và nước tiểu cũng như các mức độ toàn cầu của sự đột biến di-methylation và acetylation lysine 9 histone 3 (H3K9me2 và H3K9ac), di-methylation và acetylation lysine 27 histone 3 (H3K27me3 và H3K27ac), acetylation lysine 18 histone 3 (H3K18ac) và trimethylation lysine 4 histone 3 (H3K4me3) đã được đo ở các tế bào đơn nhân máu ngoại vi (PBMC) từ một tập hợp nhỏ của những người tham gia (N = 40) của một thí nghiệm lâm sàng về folate tại Bangladesh (nghiên cứu FACT).Kết quả: Tổng nồng độ As trong nước tiểu (uAs) có mối tương quan tích cực với H3K9me2 (r = 0,36, P = 0,02) và liên quan nghịch với H3K9ac (r = −0,47, P = 0,002). Các mối liên kết giữa As và các PTHMs khác có sự khác biệt theo giới tính. As trong nước (wAs) có mối tương quan tích cực với H3K4me3 (r = 0,45, P = 0,05) và H3K27me3 (r = 0,50, P = 0,03) ở nữ và có mối tương quan nghịch ở nam (H3K4me3: r = −0,44, P = 0,05; H3K27me3: r = −0,34, P = 0,14). Ngược lại, wAs có mối liên hệ nghịch với H3K27ac ở nữ (r = −0,44, P = 0,05) và mối liên kết tích cực ở nam (r = 0,29, P = 0,21). Một mô hình tương tự đã được quan sát đối với H3K18ac (nữ: r = −0,22, P = 0,36; nam: r = 0,27, P = 0,24).Kết luận: Sự tiếp xúc với As có liên quan đến các biến đổi toàn cầu của PTHMs; các mẫu liên kết riêng theo giới tính đã được quan sát giữa sự tiếp xúc với As và một số dấu hiệu histone.Ảnh hưởng: Những phát hiện này góp phần vào cơ sở bằng chứng ngày càng gia tăng liên kết sự tiếp xúc với As với sự rối loạn biểu sinh, có thể đóng vai trò trong sinh bệnh học của độc tính As. Epidemiol Ung thư Biomarkers Prev; 21(12); 2252–60. ©2012 AACR.

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Thông tin xuất bản

Cancer Epidemiology Biomarkers and Prevention

Tập 21 Số 12

2252-2260

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