Association of the BDNF Val66Met variation with obesity in women

Molecular Genetics and Metabolism - Tập 95 - Trang 110-112 - 2008
Sigri Beckers1, Armand Peeters1, Doreen Zegers1, Ilse Mertens2, Luc Van Gaal2, Wim Van Hul1
1Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Universiteitsplein 1, B-2610 Wilrijk, Antwerp, Belgium
2Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Belgium

Tài liệu tham khảo

Kernie, 2000, BDNF regulates eating behavior and locomotor activity in mice, EMBO J., 19, 1290, 10.1093/emboj/19.6.1290 Rios, 2001, Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity, Mol. Endocrinol., 15, 1748, 10.1210/me.15.10.1748 Lyons, 1999, Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities, Proc. Natl. Acad. Sci. USA, 96, 15239, 10.1073/pnas.96.26.15239 Friedel, 2005, Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity eating disorders and attention-deficit/hyperactivity disorder, Am. J. Med. Genet. B Neuropsychiatr. Genet., 132, 96, 10.1002/ajmg.b.30090 Gray, 2006, Hyperphagia severe obesity impaired cognitive function and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene, Diabetes, 55, 3366, 10.2337/db06-0550 Gray, 2007, Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity, Int. J. Obes. (Lond), 31, 359, 10.1038/sj.ijo.0803390 Yeo, 2004, A de novo mutation affecting human TrkB associated with severe obesity and developmental delay, Nat. Neurosci., 7, 1187, 10.1038/nn1336 Ribases, 2003, Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type, Mol. Psychiatry, 8, 745, 10.1038/sj.mp.4001281 Ribases, 2004, Association of BDNF with anorexia bulimia and age of onset of weight loss in six European populations, Hum. Mol. Genet., 13, 1205, 10.1093/hmg/ddh137 Ribases, 2005, Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations, Eur. J. Hum. Genet., 13, 428, 10.1038/sj.ejhg.5201351 Beckers, 2006, Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children, Int. J. Obes. (Lond), 30, 221, 10.1038/sj.ijo.0803126 Peeters, 2008, Variants in the FTO gene are associated with common obesity in the Belgian population, Mol. Genet. Metab., 93, 481, 10.1016/j.ymgme.2007.10.011 Xu, 2003, Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor, Nat. Neurosci., 6, 736, 10.1038/nn1073 International HapMap Project. www.hapmap.org Accessed on 12 June 2008. Egan, 2003, The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function, Cell, 112, 257, 10.1016/S0092-8674(03)00035-7 Chen, 2004, Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons, J. Neurosci., 24, 4401, 10.1523/JNEUROSCI.0348-04.2004 Oroszi, 2006, The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus, Ann. Rheum. Dis., 65, 1330, 10.1136/ard.2006.051623 Lee, 2001, Regulation of cell survival by secreted proneurotrophins, Science, 294, 1945, 10.1126/science.1065057