Sự liên quan giữa các biến thể gen thụ thể estrogen β với chứng sa sút trí tuệ mạch máu ở phụ nữ

Neurological Sciences - Tập 33 - Trang 1029-1035 - 2011
Jiawei Xin1, Junjian Zhang1, Yongzhe Gao1, Li Xiong1
1Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, China

Tóm tắt

Mục tiêu của nghiên cứu hiện tại là khám phá mối liên quan tiềm năng giữa các biến thể gen thụ thể estrogen β (ERβ) và chứng sa sút trí tuệ mạch máu (VaD) ở phụ nữ. Mối quan hệ của hai biến thể (rs944050 và rs4986938) và các kiểu gen liên quan của gen ERβ với VaD đã được khảo sát trên 121 phụ nữ người Hán Trung Quốc (>50 tuổi), bao gồm 61 người mắc VaD và 60 người đối chứng khỏe mạnh có độ tuổi tương đồng. Các liên quan tiềm năng được đánh giá bằng phương pháp hồi quy logistic không điều kiện. Allele biến thể G của rs944050 trong gen ERβ làm tăng nguy cơ mắc VaD (tỷ lệ odds = 2.02, khoảng tin cậy 95% = 1.08–3.77). Trong các phân tích kiểu gen, kiểu gen ERβ chứa allele biến thể của biến thể rs944050 và allele kiểu hoang của biến thể rs4986938 đã liên quan đến VaD (tỷ lệ odds = 1.70, khoảng tin cậy 95% = 1.03–2.84). Biến thể rs944050 trong gen ERβ có liên quan đến nguy cơ cao hơn trong việc mắc VaD ở phụ nữ người Hán Trung Quốc. Cần có các nghiên cứu thêm về mối liên quan giữa các biến thể gen ERβ và VaD để xác nhận các phát hiện này.

Từ khóa

#thụ thể estrogen β #chứng sa sút trí tuệ mạch máu #phụ nữ #biến thể gen #mối liên quan

Tài liệu tham khảo

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