Mối liên quan giữa xơ gan mật nguyên phát và đa hình gen thụ thể vitamin D BsmI trong một quần thể Hungary

Digestive Diseases and Sciences - Tập 45 - Trang 1091-1095 - 2000
Balazs Halmos1,2,3,4, Ferenc Szalay1,2,3,4, Tamas Cserniczky1,2,3,4, Elemer Nemesanszky1,2,3,4, Peter Lakatos1,2,3,4, Stefan Barlage1,2,3,4, Gerd Schmitz1,2,3,4, Laszlo Romics1,2,3,4, Albert Csaszar1,2,3,4
13rd Department of Medicine, and 1st Department of Medicine, Semmelweis University, Budapest, Hungary
2Department of Rheumatology, St. Rokus Hospital, Budapest, Hungary
3Department of Medicine, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary
4Department of Clinical Chemistry, University of Regensburg, Germany

Tóm tắt

Chúng tôi đã tìm hiểu sự phân bố của các kiểu gen thụ thể vitamin D được xác định bởi biến dị BsmI và điều tra mối liên hệ của chúng với mật độ khoáng xương ở bệnh nhân xơ gan mật nguyên phát. Kiểu gen thụ thể vitamin D và mật độ khoáng xương tại cột sống thắt lưng được xác định trong 31 bệnh nhân nữ Hungary mắc xơ gan mật nguyên phát và 51 nữ đối chứng khỏe mạnh phù hợp về tuổi tác. Tần suất kiểu gen (BB: 45%, Bb: 32%, bb: 22%) ở nhóm bệnh nhân khác biệt đáng kể so với nhóm đối chứng (P = 0.01) do sự chiếm ưu thế của kiểu gen BB. Có một xu hướng rõ rệt, nhưng không đạt được ý nghĩa thống kê, cho thấy mật độ khoáng xương thấp hơn ở cả hai nhóm bệnh nhân và đối chứng mang allele B. Tóm lại, chúng tôi phát hiện tần suất kiểu gen BB cao đáng kể ở bệnh nhân xơ gan mật nguyên phát, điều này đặt ra những câu hỏi về ảnh hưởng của hormone đối với sự phát triển của xơ gan mật nguyên phát.

Từ khóa

#xơ gan mật nguyên phát #thụ thể vitamin D #biến dị BsmI #mật độ khoáng xương #bệnh nhân nữ Hungary

Tài liệu tham khảo

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