Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer

Jocelyne Jacquemier1,2, Emmanuelle Charafe-Jauffret1,2, Florence Monville1,2, Benjamin Esterni3, Jean Marc Extra4, Gilles Houvenaeghel5, Luc Xerri6, François Bertucci7, Daniel Birnbaum2,1
1Département d'Oncologie Moléculaire Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, UMR891 Inserm
2IFR137, 232 Bd sainte Marguerite, Marseille, 13009, France
3Département de Biostatistiques, Institut Paoli-Calmettes, 232 Bd Ste Marguerite, Marseille, 13009, France
4Département d'Oncologie Médicale, Institut Paoli-Calmettes, 232 Bd Ste Marguerite, Marseille, 13009, France
5Département d'Oncologie Chirurgicale, Institut Paoli-Calmettes, 232 Bd Ste Marguerite, Marseille, 13009, France
6Département de BioPathologie, Institut Paoli-Calmettes, 232 Bd sainte Marguerite, Marseille, 13009, France
7UFR de Médecine, Université de la Méditerranée, 58 Bd Charles Livon, Marseille, 13284, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA. 2003, 100: 8418-8423. 10.1073/pnas.0932692100.

Bertucci F, Houlgatte R, Granjeaud S, Nasser V, Loriod B, Beaudoing E, Hingamp P, Jacquemier J, Viens P, Birnbaum D, Nguyen C: Prognosis of breast cancer and gene expression profiling using DNA arrays. Ann N Y Acad Sci. 2002, 975: 217-231.

Charafe-Jauffret E, Ginestier C, Monville F, Fekairi S, Jacquemier J, Birnbaum D, Bertucci F: How to best classify breast cancer: conventional and novel classifications (review). Int J Oncol. 2005, 27: 1307-1313.

Bremer TM, Jacquemier J, Charafe-Jauffret E, Viens P, Birnbaum D, Linke SP: Prognostic marker profile to assess risk in stage I–III hormone receptor-positive breast cancer patients. Int J Cancer. 2009, 124: 896-904. 10.1002/ijc.24001.

Finetti P, Cervera N, Charafe-Jauffret E, Chabannon C, Charpin C, Chaffanet M, Jacquemier J, Viens P, Birnbaum D, Bertucci F: Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis. Cancer Res. 2008, 68: 767-776. 10.1158/0008-5472.CAN-07-5516.

Manie E, Vincent-Salomon A, Lehmann-Che J, Pierron G, Turpin E, Warcoin M, Gruel N, Lebigot I, Sastre-Garau X, Lidereau R, Remenieras A, Feunteun J, Delattre O, de The H, Stoppa-Lyonnet D, Stern MH: High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. Cancer Res. 2009, 69: 663-671. 10.1158/0008-5472.CAN-08-1560.

Wilson BJ, Giguere V: Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway. Mol Cancer. 2008, 7: 49-10.1186/1476-4598-7-49.

Wolf I, Bose S, Williamson EA, Miller CW, Karlan BY, Koeffler HP: FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer. Int J Cancer. 2007, 120: 1013-1022. 10.1002/ijc.22389.

Thorat MA, Marchio C, Morimiya A, Savage K, Nakshatri H, Reis-Filho JS, Badve S: Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis. J Clin Pathol. 2008, 61: 327-332. 10.1136/jcp.2007.052431.

Badve S, Turbin D, Thorat MA, Morimiya A, Nielsen TO, Perou CM, Dunn S, Huntsman DG, Nakshatri H: FOXA1 expression in breast cancer – correlation with luminal subtype A and survival. Clin Cancer Res. 2007, 13: 4415-4421. 10.1158/1078-0432.CCR-07-0122.

Nakshatri H, Badve S: FOXA1 as a therapeutic target for breast cancer. Expert Opin Ther Targets. 2007, 11: 507-514. 10.1517/14728222.11.4.507.

Moinfar F, Okcu M, Tsybrovskyy O, Regitnig P, Lax SF, Weybora W, Ratschek M, Tavassoli FA, Denk H: Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies. Cancer. 2003, 98: 703-711. 10.1002/cncr.11532.

Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME: Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study. Cancer Res. 2007, 67: 10608-10617. 10.1158/0008-5472.CAN-07-2142.

Agrawal AK, Jelen M, Grzebieniak Z, Zukrowski P, Rudnicki J, Nienartowicz E: Androgen receptors as a prognostic and predictive factor in breast cancer. Folia Histochem Cytobiol. 2008, 46: 269-276. 10.2478/v10042-008-0039-y.

Callagy GM, Webber MJ, Pharoah PD, Caldas C: Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer. BMC Cancer. 2008, 8: 153-

Theillet C, Adelaide J, Louason G, Bonnet-Dorion F, Jacquemier J, Adnane J, Longy M, Katsaros D, Sismondi P, Gaudray P: FGFRI and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers. Genes Chromosomes Cancer. 1993, 7: 219-226. 10.1002/gcc.2870070407.

Bioconductor. [ http://www.bioconductor.org ]

Ginestier C, Charafe-Jauffret E, Bertucci F, Eisinger F, Geneix J, Bechlian D, Conte N, Adelaide J, Toiron Y, Nguyen C, Viens P, Mozziconacci MJ, Houlgatte R, Birnbaum D, Jacquemier J: Distinct and complementary information provided by use of tissue and DNA microarrays in the study of breast tumor markers. Am J Pathol. 2002, 161: 1223-1233.

Jacquemier J, Ginestier C, Rougemont J, Bardou VJ, Charafe-Jauffret E, Geneix J, Adelaide J, Koki A, Houvenaeghel G, Hassoun J, Maraninchi D, Viens P, Birnbaum D, Bertucci F: Protein expression profiling identifies subclasses of breast cancer and predicts prognosis. Cancer Res. 2005, 65: 767-779.

Kaplan EMP: Nonparametric estimation for incomplete estimation. J am stat Assoc. 1958, 457-462. 10.2307/2281868.

Cox DR: Regression Models and Life Tables. Journal of the royal statistical Society. 1972, B34: 187-220.

Kamikubo KMHMK: microcomputer-based non linear regression analysis of ligand-binding data: application of Akaike's information criteria. jpn j pharmacol. 2008, 40: 342-346. 10.1254/jjp.40.342.

The R-Project for Statistical Programming. [ http://www.r-project.org ]

Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de RM, Perou CM: Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res. 2004, 10: 5367-5374. 10.1158/1078-0432.CCR-04-0220.

Mohammed RA, Ellis IO, Lee AH, Martin SG: Vascular invasion in breast cancer; an overview of recent prognostic developments and molecular pathophysiological mechanisms. Histopathology. 2008

Wilson BJ, Giguere V: Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway. Mol Cancer. 2008, 7: 49-10.1186/1476-4598-7-49.

Ciocca V, Daskalakis C, Ciocca RM, Ruiz-Orrico A, Palazzo JP: The significance of GATA3 expression in breast cancer: a 10-year follow-up study. Hum Pathol. 2008

Spitale A, Mazzola P, Soldini D, Mazzucchelli L, Bordoni A: Breast cancer classification according to immunohistochemical markers: clinicopathologic features and short-term survival analysis in a population-based study from the South of Switzerland. Ann Oncol. 2008

Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004, 351: 2817-2826. 10.1056/NEJMoa041588.

Paik S, Tang G, Shak S, Kim C, Baker J, Kim W, Cronin M, Baehner FL, Watson D, Bryant J, Costantino JP, Geyer CE, Wickerham DL, Wolmark N: Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol. 2006, 24: 3726-3734. 10.1200/JCO.2005.04.7985.

Loi S, Haibe-Kains B, Desmedt C, Wirapati P, Lallemand F, Tutt AM, Gillet C, Ellis P, Ryder K, Reid JF, Daidone MG, Pierotti MA, Berns EM, Jansen MP, Foekens JA, Delorenzi M, Bontempi G, Piccart MJ, Sotiriou C: Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics. 2008, 9: 239-10.1186/1471-2164-9-239.

Oh DS, Troester MA, Usary J, Hu Z, He X, Fan C, Wu J, Carey LA, Perou CM: Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers. J Clin Oncol. 2006, 24: 1656-1664. 10.1200/JCO.2005.03.2755.

Ring BZ, Seitz RS, Beck R, Shasteen WJ, Tarr SM, Cheang MC, Yoder BJ, Budd GT, Nielsen TO, Hicks DG, Estopinal NC, Ross DT: Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer. J Clin Oncol. 2006, 24: 3039-3047. 10.1200/JCO.2006.05.6564.