Association between high-sensitivity troponin T, left ventricular hypertrophy, and myocardial performance index

Herz - Tập 40 Số 7 - Trang 1004-1010 - 2015
Kaypakli, Onur1, Gür, Mustafa1, Gözükara, Mehmet Yavuz2, Uçar, Hakan1, Kivrak, Ali1, Şeker, Taner1, Şahin, Durmuş Yildiray1, Elbasan, Zafer1, Türkoğlu, Caner1, Çayli, Murat1
1Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey
2Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey

Tóm tắt

The prognostic importance of high-sensitivity cardiac troponin T (hs-cTnT) has recently been reported in patients with heart failure. The myocardial performance index (MPI), which combines parameters of both systolic and diastolic ventricular function, provides a better marker of left ventricular dysfunction in hypertensive patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the relationship between hs-cTnT and tissue Doppler-derived MPI in newly diagnosed hypertensive patients with preserved LVEF. We studied 306 patients with newly diagnosed hypertension. The patients were divided into two groups according to their median MPI values: MPIlo and MPIhigh groups. The MPI was calculated from the pulsed-wave Doppler recordings. Left ventricular mass index (LVMI) was determined according to the Devereux formula. hs-cTnT, uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels were measured in all patients. Hs-cTnT, hs-CRP, and uric acid levels were higher in the MPIhigh group compared with the MPIlow group (p < 0.05, for all). The LVMI values in the MPIhigh group were higher than in the MPIlow group (p < 0.05). MPI was independently associated with age, uric acid, hs-cTnT, and LVMI in multivariate analysis. Multivariate logistic regression analysis showed that MPI and LVMI were independent predictors of high hs-cTnT level in newly diagnosed hypertensive patients with preserved LVEF. Hs-cTnT was independently associated with LV dysfunction and LV hypertrophy assessed with MPI in newly diagnosed hypertensive patients.

Tài liệu tham khảo

citation_journal_title=J Cardiol; citation_title=Left ventricular systolic function is abnormal in diastolic heart failure: re-assessment of systolic function using cardiac time interval analysis; citation_author=M Kono, A Kisanuki, K Takasaki; citation_volume=53; citation_publication_date=2009; citation_pages=437-446; citation_doi=10.1016/j.jjcc.2009.02.014; citation_id=CR1

citation_journal_title=Heart; citation_title=Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition; citation_author=G Yip, M Wang, Y Zhang; citation_volume=87; citation_publication_date=2002; citation_pages=121-125; citation_doi=10.1136/heart.87.2.121; citation_id=CR2

citation_journal_title=J Am Soc Echocardiogr; citation_title=Noninvasive Doppler derived myocardial performance index: correlation with simultaneous measurements of cardiac catheterization measurements; citation_author=C Tei, RA Nishimura, JB Seward; citation_volume=10; citation_publication_date=1997; citation_pages=169-178; citation_doi=10.1016/S0894-7317(97)70090-7; citation_id=CR3

citation_journal_title=Am J Cardiol; citation_title=Contraction and relaxation velocities of the normal left ventricle using pulsed-wave tissue Doppler echocardiography; citation_author=L Galiuto, G Ignone, A DeMaria; citation_volume=81; citation_publication_date=1998; citation_pages=609-614; citation_doi=10.1016/S0002-9149(97)00990-9; citation_id=CR4

citation_journal_title=Can J Cardiol; citation_title=Effects of allopurinol on coronary microvascular and left ventricular function in patients with idiopathic dilated cardiomyopathy; citation_author=D Erdogan, S Tayyar, BA Uysal, A Icli, M Karabacak, M Ozaydin, A Dogan; citation_volume=28; citation_issue=6; citation_publication_date=2012; citation_pages=721-727; citation_doi=10.1016/j.cjca.2012.04.005; citation_id=CR5

citation_journal_title=Adv Chronic Kidney Dis; citation_title=Hyperuricemia and hypertension; citation_author=DI Feig; citation_volume=19; citation_issue=6; citation_publication_date=2012; citation_pages=377-385; citation_doi=10.1053/j.ackd.2012.05.009; citation_id=CR6

citation_journal_title=J Cardiol; citation_title=High-sensitivity cardiac troponin T in essential hypertension; citation_author=Y Sato, E Yamamoto, T Sawa; citation_volume=58; citation_issue=3; citation_publication_date=2011; citation_pages=226-231; citation_doi=10.1016/j.jjcc.2011.07.009; citation_id=CR7

citation_journal_title=J Hypertens; citation_title=High-sensitivity troponin T predicts worsening of albuminuria in hypertension; results of a nested case-control study with confirmation in diabetes; citation_author=ME Hellemons, HJ Lambers Heerspink; citation_volume=31; citation_issue=4; citation_publication_date=2013; citation_pages=805-812; citation_doi=10.1097/HJH.0b013e32835eb5e8; citation_id=CR8

citation_journal_title=JAMA; citation_title=Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population; citation_author=JA Lemos, MH Drazner, T Omland; citation_volume=304; citation_issue=22; citation_publication_date=2010; citation_pages=2503-2512; citation_doi=10.1001/jama.2010.1768; citation_id=CR9

citation_journal_title=Am J Hypertens; citation_title=Relation between nocturnal decline in blood pressure and mortality, the Ohasama Study; citation_author=T Ohkubo, Y Imai, I Tsuji; citation_volume=10; citation_publication_date=1997; citation_pages=1201-1207; citation_doi=10.1016/S0895-7061(97)00274-4; citation_id=CR10

citation_journal_title=J Am Soc Echocardiogr; citation_title=Chamber Quantification Writing Group. Recommendations for Chamber Quantification: a report from the American Society of Echocardiography; citation_author=RM Lang, M Bierig, RB Devereux; citation_volume=18; citation_publication_date=2005; citation_pages=1440-1463; citation_doi=10.1016/j.echo.2005.10.005; citation_id=CR11

citation_journal_title=J Am Soc Echocardiogr; citation_title=Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms; citation_author=NB Schiller, PM Shah, M Crawford; citation_volume=2; citation_publication_date=1989; citation_pages=358-367; citation_doi=10.1016/S0894-7317(89)80013-6; citation_id=CR12

citation_journal_title=Circulation; citation_title=Reichek: echocardiographic determination of left ventricular mass in man, anatomic validation of the method; citation_author=RB Devereux; citation_volume=55; citation_publication_date=1977; citation_pages=613-618; citation_doi=10.1161/01.CIR.55.4.613; citation_id=CR13

citation_journal_title=Expert Rev Cardiovasc Ther; citation_title=World Health Organization-International Society of Hypertension (WHO-ISH); USA Joint National Committee on Prevention, Detection, Evalutiaon, and Treatment of High Blood Pressure (JNC-7); European Soceity of Hypertension-European Society of Cardiology (ESH-ESC). New European, American and International guidelines for hypertension management: agreement and disagreement; citation_author=GS Stergiou, EV Salgami; citation_volume=2; citation_publication_date=2004; citation_pages=359-368; citation_doi=10.1586/14779072.2.3.359; citation_id=CR14

citation_journal_title=Circulation; citation_title=Progression of systolic abnormalities in patients with “isolated” diastolic heart failure and diastolic dysfunction; citation_author=CM Yu, H Lin, H Yang; citation_volume=105; citation_publication_date=2002; citation_pages=1195-1201; citation_doi=10.1161/hc1002.105185; citation_id=CR15

citation_journal_title=Circ J; citation_title=Transition from asymptomatic diastolic dysfunction to heart failure with preserved ejection fraction: roles of systolic function and ventricular distensibility; citation_author=Y Aizawa, Y Sakata, T Mano; citation_volume=75; citation_publication_date=2011; citation_pages=596-602; citation_doi=10.1253/circj.CJ-10-1037; citation_id=CR16

citation_journal_title=Circ J; citation_title=Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension; citation_author=K Takasaki, M Miyata, M Imamura; citation_volume=76; citation_publication_date=2012; citation_pages=1409-1114; citation_doi=10.1253/circj.CJ-11-1369; citation_id=CR17

citation_journal_title=J Cardiol; citation_title=New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function-a study in normalsand dilated cardiomyopathy; citation_author=C Tei, L Ling, D Hodge; citation_volume=26; citation_publication_date=1995; citation_pages=357-366; citation_id=CR18

citation_journal_title=J Cardiol; citation_title=New non-invasive index of combined systolic and diastolic ventricular function; citation_author=C Tei; citation_volume=26; citation_publication_date=1995; citation_pages=135-136; citation_id=CR19

citation_journal_title=J Am Coll Cardiol; citation_title=Doppler index combining systolic and diastolic myocardial performance: clinical value in cardiac amyloidosis; citation_author=C Tei, K Dujardin, D Hodge; citation_volume=28; citation_publication_date=1996; citation_pages=658-664; citation_doi=10.1016/0735-1097(96)00202-1; citation_id=CR20

citation_journal_title=Hellenic J Cardiol; citation_title=A new Doppler index combining systolic and diastolic myocardial performance. Behavior and significance during hospitalization of patients with acute myocardial infarction; citation_author=N Nearchou, A Tsakiris, D Stathakopoulos; citation_volume=40; citation_publication_date=1999; citation_pages=486-496; citation_id=CR21

citation_journal_title=J Am Soc Echocardiogr; citation_title=Serial Doppler echocardiographic assessment of left and right ventricular performance after a first myocardial infarction; citation_author=J Moller, E Sondergaard, S Poulsen; citation_volume=14; citation_publication_date=2001; citation_pages=249-255; citation_doi=10.1067/mje.2001.111478; citation_id=CR22

citation_journal_title=Eur Heart J; citation_title=Tei index in patients with mild to moderate congestive heart failure; citation_author=C Bruch, A Schmermund, D Marin; citation_volume=21; citation_publication_date=2000; citation_pages=1888-1895; citation_doi=10.1053/euhj.2000.2246; citation_id=CR23

citation_journal_title=J Am Soc Echocardiogr; citation_title=The influence of heart rate on the Doppler derived myocardial performance index; citation_author=S Poulsen, J Nielsen, H Andersen; citation_volume=13; citation_publication_date=2000; citation_pages=379-384; citation_doi=10.1016/S0894-7317(00)70007-1; citation_id=CR24

citation_journal_title=Orv Hetil; citation_title=Effect of chronic amiodarone therapy on left ventricular function in dilated cardiomyopathy studied by the new Doppler-index; citation_author=M Lengyel; citation_volume=139; citation_publication_date=1998; citation_pages=1147-1151; citation_id=CR25

citation_journal_title=J Int Med Res; citation_title=Evaluation of right-ventricular function by Doppler echocardiography in patients with chronic respiratory failure; citation_author=E Nishimura, S Ikeda, T Naito; citation_volume=27; citation_publication_date=2009; citation_pages=65-73; citation_id=CR26

citation_journal_title=N Engl J Med; citation_title=Early diagnosis of myocardial infarction with sensitive cardiac troponin assays; citation_author=T Reichlin, W Hochholzer, S Bassetti; citation_volume=361; citation_publication_date=2009; citation_pages=858-867; citation_doi=10.1056/NEJMoa0900428; citation_id=CR27

citation_journal_title=BMC Pulmonary Medicine; citation_title=Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study; citation_author=AD Høiseth, T Omland, T Hagve; citation_volume=12; citation_publication_date=2012; citation_pages=22; citation_doi=10.1186/1471-2466-12-22; citation_id=CR28

citation_journal_title=Int Heart J; citation_title=Elevated cardiac troponin T predicts adverse outcomes in hypertensive patients; citation_author=K Setsuta, Y Kitahara, M Arae; citation_volume=52; citation_publication_date=2011; citation_pages=164-169; citation_doi=10.1536/ihj.52.164; citation_id=CR29

citation_journal_title=N Engl J Med; citation_title=Coronary microvascular dysfunction; citation_author=PG Camici, F Crea; citation_volume=356; citation_publication_date=2007; citation_pages=830-840; citation_doi=10.1056/NEJMra061889; citation_id=CR30

citation_journal_title=Hypertension; citation_title=Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management; citation_author=MA Fortu˜no, S Ravassa, A Fortu˜no; citation_volume=38; citation_publication_date=2001; citation_pages=1406-1412; citation_doi=10.1161/hy1201.099615; citation_id=CR31

citation_journal_title=Int J Clin Pract; citation_title=Relationship between myocardial performance index and aortic distensibility in patients with essential hypertension; citation_author=M Gur, R Yilmaz, R Demirbag; citation_volume=62; citation_publication_date=2008; citation_pages=138-142; citation_doi=10.1111/j.1742-1241.2006.01202.x; citation_id=CR32

citation_journal_title=Am J Cardiol; citation_title=Prognostic value of a Doppler index combining systolic and diastolic performance in idiopathic-dilated cardiomyopathy; citation_author=KS Dujardin, C Tei, TC Yeo; citation_volume=82; citation_publication_date=1998; citation_pages=1071-1076; citation_doi=10.1016/S0002-9149(98)00559-1; citation_id=CR33

citation_journal_title=Herz; citation_title=Ventricular hypertrophy and hypertension: prognostic elements and implications for management; citation_author=DG Krauser, RB Devereux; citation_volume=31; citation_publication_date=2006; citation_pages=305-316; citation_doi=10.1007/s00059-006-2819-5; citation_id=CR34

citation_journal_title=Cardiovasc Res; citation_title=Cardiomyocyte apoptosis in hypertensive cardiomyopathy; citation_author=A González, MA Fortuño, R Querejeta; citation_volume=59; citation_publication_date=2003; citation_pages=549-562; citation_doi=10.1016/S0008-6363(03)00498-X; citation_id=CR35

citation_journal_title=Clin Chim Acta; citation_title=Cardiac troponin may be released by ischemia alone, without necrosis; citation_author=PE Hickman, JM Potter, C Aroney; citation_volume=411; citation_publication_date=2010; citation_pages=318-323; citation_doi=10.1016/j.cca.2009.12.009; citation_id=CR36

citation_journal_title=Int J Hypertens; citation_title=Left ventricular hypertrophy: major risk factor in patients with hypertension: update and practical clinical applications; citation_author=RE Katholi, DM Couri; citation_volume=2011; citation_publication_date=2011; citation_pages=495349; citation_doi=10.4061/2011/495349; citation_id=CR37

citation_journal_title=Circulation; citation_title=Losartan Intervention for Endpoint reduction in hypertension Study Investigations. Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: the Losartan Intervention for Endpoint reduction in Hypertension (LIFE) Study; citation_author=PM Okin, RB Devereux, S Jern, SE Kjeldsen, S Julius, MS Nieminen, S Snapinn, KE Harris, P Aurup, JM Edelman; citation_volume=108; citation_publication_date=2003; citation_pages=684-690; citation_doi=10.1161/01.CIR.0000083724.28630.C3; citation_id=CR38

citation_journal_title=N Engl J Med; citation_title=Prognostic implications of echocardiographically determined LV mass in the Framingham heart study; citation_author=D Levy, RJ Garrison, DD Savage, WB Kannel, WP Castelli; citation_volume=322; citation_publication_date=1990; citation_pages=1561-1566; citation_doi=10.1056/NEJM199005313222203; citation_id=CR39

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Herz

Tập 40 Số 7

1004-1010

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