Đánh giá sự khởi phát melatonin trong điều kiện ánh sáng mờ ở người lớn mắc Rối loạn phổ Tự kỷ và không có khuyết tật trí tuệ đi kèm

Journal of Autism and Developmental Disorders - Tập 47 - Trang 2120-2137 - 2017
Emma K. Baker1,2, Amanda L. Richdale1,2, Agnes Hazi2, Luke A. Prendergast3
1School of Psychology and Public Health, Olga Tennison Autism Research Centre, La Trobe University, Bundoora, Australia
2School of Psychology and Public Health, La Trobe University, Bundoora, Australia
3School of Mathematics and Statistics, La Trobe University, Bundoora, Australia

Tóm tắt

Nghiên cứu này đánh giá nồng độ melatonin và sự khởi phát melatonin trong điều kiện ánh sáng mờ (DLMO) ở người lớn mắc Rối loạn phổ Tự kỷ (ASD) và cũng điều tra mối quan hệ giữa melatonin và các tham số giấc ngủ được đo một cách khách quan. Mười sáu người lớn mắc ASD (chỉ ASD), 12 người lớn mắc ASD đang dùng thuốc điều trị các rối loạn phối hợp lo âu và/hoặc trầm cảm (ASD-Med) và 32 người đối chứng đã tham gia nghiên cứu. Mặc dù thời gian khởi phát DLMO không có sự khác biệt giữa hai nhóm, nhưng các sự tiến bộ và trì hoãn của nhịp melatonin đã được quan sát trong các hồ sơ cá nhân. Mức melatonin trung bình tổng thể thấp hơn ở nhóm ASD-Med so với hai nhóm còn lại. Cuối cùng, sự gia tăng melatonin lớn hơn trong giờ trước khi ngủ được liên kết với hiệu suất giấc ngủ tốt hơn ở các nhóm ASD.

Từ khóa

#Rối loạn phổ Tự kỷ #Melatonin #Khởi phát melatonin trong điều kiện ánh sáng mờ #Giấc ngủ #Tham số giấc ngủ

Tài liệu tham khảo

American Academy of Sleep Medicine (2014). International Classification of Sleep Disorders (3rd edn.). Darien, IL: American Academy of Sleep Medicine. Antonioli, M., Rybka, J., & Carvalho, L. A. (2012). Neuroimmune endocrine effects of antidepressants. Neuropsychiatric Disease and Treatment, 8, 65–83. doi:10.2147/NDT.S16409. Arendt, J. (1995). Melatonin and the mammalian pineal gland (1st ed.). London: Chapman & Hall. Baker, E. K., & Richdale, A. L. (2015). Sleep patterns in adults with a diagnosis of high-functioning autism spectrum disorder. Sleep, 38(11), 1765–1774. doi:10.5665/sleep.5160. Baker, E. K., & Richdale, A. L. (2017). Examining the behavioural sleep–wake rhythm in adults with autism spectrum disorder and no comorbid intellectual disability. Journal of Autism and Developmental Disorders, 47, 1207–1222. doi:10.1007/s10803-017-3042-3. Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from asperger syndrome/high-functioning autism, malesand females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. doi:10.1023/a:1005653411471. Benloucif, S., Burgess, H. J., Klerman, E. B., Lewy, A. J., Middleton, B., Murphy, P. J., … Revell, V. L. (2008). Measuring melatonin in humans. Journal of Clinical Sleep Medicine, 4, 66–69. Benowitz, N. L. (1990). Clinical pharmacology of caffeine. Annual Review of Medicine, 41, 277–288. doi:10.1146/annurev.me.41.020190.001425. Bootzin, R., Shoham, V., & Kuo, T. (1994). Sleep anticipatory anxiety questionnaire: A measure of anxiety about sleep. Sleep Research, 23, 188. Brzezinski, A. (1997). Melatonin in humans. The New England Journal of Medicine, 336(3), 186–195. doi:10.1056/NEJM199701163360306. Burgess, H. J., & Eastman, C. I. (2005). The dim light melatonin onset following fixed and free sleep schedules. Journal of Sleep Research, 14(3), 229–237. doi:10.1111/j.1365-2869.2005.00470.x. Burgess, H. J., Wyatt, J. K., Park, M., & Fogg, L. F. (2015). Home circadian phase assessments with measures of compliance yield accurate dim light melatonin onsets. Sleep, 38(6), 889–897. doi:10.5665/sleep.4734. Carvalho, L. A., Gorenstein, C., Moreno, R., Pariante, C., & Markus, R. P. (2009). Effect of antidepressants on melatonin metabolite in depressed patients. Journal of Psychopharmacology, 23(3), 315–321. doi:10.1177/0269881108089871. Cohrs, S., Pohlmann, K., Guan, Z., Jordan, W., Meier, A., Huether, G., Rüther, E., & Rodenbeck, A. (2004). Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects. Psychopharmacology, 174, 414–420, doi:10.1007/s00213-003-1766-6. Cortesi, F., Giannotti, F., Sebastiani, T., Panunzi, S., & Valente, D. (2012). Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. Journal of Sleep Research, 21(6), 700–709, doi:10.1111/j.1365-2869.2012.01021.x. Crasson, M., Kjiri, S., Colin, A., Kjiri, K., L’Hermite-Baleriaux, M., Ansseau, M., et al. (2004). Serum melatonin and urinary 6-sulfatoxymelatonin in major depression. Psychoneuroendocrinology, 29(1), 1–12. [doi:10.1016/S0306-4530(02)00123-3]. Crowley, S. J. (2013). Assessment of Circadian Rhythms. In A. Wolfson & H. Montgomery-Downs (Eds.), The Oxford Handbook of Infant, Child, and Adolescent Sleep and Behavior. New York, NY: Oxford University Press. Darcourt, G., Feuillade, P., Bistagnin, Y., Robert, P., Pringuey, D., Touari, M., Mrdji, Y., & Bensmaïl, B. (1995). Antidepressant effect of 5-methoxypsoralen: The melatonin synchronizer hypothesis. European Psychiatry, 10(3), 142–154. doi:10.1016/0767-399X(96)80103-9. Dijk, D. J., & Cajochen, C. (1997). Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. Journal of Biological Rhythms, 12(6), 627–635. Elrod, M. G., & Hood, B. S. (2015). Sleep differences among children with autism spectrum disorders and typically developing peers: A meta-analysis. Journal of Developmental and Behavioral Pediatrics, 36(3), 166–177. Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009). Circadian misalignment in major depressive disorder. Psychiatry Research, 168(3), 259–261. doi:10.1016/j.psychres.2009.04.009. Franklin, M., Clement, E. M., Campling, G., & Cowen, P. J. (1998). Effect of venlafaxine on pineal melatonin and noradrenaline in the male rat. Journal of Psychopharmacology, 12(4), 371–374. Glickman, G. (2010). Circadian rhythms and sleep in children with autism. Neuroscience and Biobehavioral Reviews, 34(5), 755–768. doi:10.1016/j.neubiorev.2009.11.017. Goldman, S. E., Adkins, K. W., Calcutt, M. W., Carter, M. D., Goodpaster, R. L., Wang, L., et al. (2014). Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep. Journal of Autism and Developmental Disorders, 44(10), 2525–2535. doi:10.1007/s10803-014-2123-9. Goldman, S. E., Surdyka, K., Cuevas, R., Adkins, K., Wang, L., & Malow, B. (2009). Defining the sleep phenotype in children with autism. Developmental Neuropsychology, 34(5), 560–573. doi:10.1080/87565640903133509. Gotham, K., Brunwasser, S. M., & Lord, C. (2015). Depressive and anxiety symptom trajectories from school age through young adulthood in samples with autism spectrum disorder and developmental delay. Journal of the American Academy of Child & Adolescent Psychiatry, 54(5), 369–376.e363. doi:10.1016/j.jaac.2015.02.005. Gringras, P., Gamble, C., Jones, A. P., Wiggs, L., Williamson, P. R., Sutcliffe, A., et al. (2012). Melatonin for sleep problems in children with neurodevelopmental disorders: Randomised double masked placebo controlled trial. BMJ (Clinical research ed.), 345, e6664. doi:10.1136/bmj.e6664. Guénolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J.-M. (2011). Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion. Sleep Medicine Reviews, 15(6), 379–387. Hallam, K. T., Begg, D. P., Olver, J. S., & Norman, T. R. (2008). An investigation of the effect of immediate and extended release venlafaxine on nocturnal melatonin and cortisol release in healthy adult volunteers. Human Psychopharmacology: Clinical and Experimental, 23(2), 129–137. doi:10.1002/hup.913. Hare, D. J., Jones, S., & Evershed, K. (2006). A comparative study of circadian rhythm functioning and sleep in people with Asperger syndrome. Autism: The International Journal of Research and Practice, 10(6), 565–575. doi:10.1177/1362361306068509. Hariharasubramanian, N., Nair, N. P., Pilapil, C., Isaac, I., & Quirion, R. (1986). Effect of imipramine on the circadian rhythm of plasma melatonin in unipolar depression. Chronobiology International, 3(1), 65–69. Härtter, S., Want, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F., & Hiemke, C. (2001). Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. Journal of Clinical Psychopharmacology, 21(2), 167–174. Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010). Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: Further evidence for circadian misalignment in non-seasonal depression. Psychiatry Research, 178(1), 205–207. doi:10.1016/j.psychres.2010.04.027. Hilli, J., Korhonen, T., Turpeinen, M., Hokkanen, J., Mattila, S., & Laine, K. (2008). The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C > A polymorphism. Journal of Clinical Pharmacology, 48(8), 986–994. doi:10.1177/0091270008318669. Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325. doi:10.1007/s10803-012-1679-5. Keijzer, H., Smits, M. G., Duffy, J. F., & Curfs, L. M. (2014). Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep Medicine Reviews, 18(4), 333–339. doi:10.1016/j.smrv.2013.12.001. Kroenke, K., Strine, T. W., Spitzer, R. L., Williams, J. B. W., Berry, J. T., & Mokdad, A. H. (2009). The PHQ-8 as a measure of current depression in the general population. Journal of Affective Disorders, 114(1–3), 163–173. doi:10.1016/j.jad.2008.06.026. Kulman, G., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., & Sequeri, P. (2000). Evidence of pineal endocrine hypofunction in autistic children. Neuro Endocrinology Letters, 21(1), 31–34. Li, S., Liu, L., Xu, L., Gao, L., Wang, X., Zhang, J., & Lu, L. (2013). Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment. Psychoneuroendocrinology, 38, 2789–2899, doi:10.1016/j.psyneuen.2013.07.009. Leu, R. M., Beyderman, L., Botzolakis, E. J., Surdyka, K., Wang, L., & Malow, B. A. (2011). Relation of melatonin to sleep architecture in children with autism. [Research Support, Non-U.S. Gov’t]. Journal of Autism and Developmental Disorders, 41(4), 427–433, doi:10.1007/s10803-010-1072-1. Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism Diagnostic Observation Schedule (2nd edn.). Los Angeles, CA: Western Psychological Services. Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., et al. (2012). Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. Journal of Autism and Developmental Disorders, 42(8), 1729–1737. doi:10.1007/s10803-011-1418-3. Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsater, H., et al. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13(1), 90–98. doi:10.1038/sj.mp.4002016. Morin, L. P., & Allen, C. N. (2006). The circadian visual system, 2005. Brain Research Reviews, 51(1), 1–60. doi:10.1016/j.brainresrev.2005.08.003. Nadeau, J. M., Arnold, E. B., Keene, A. C., Collier, A. B., Lewin, A. B., Murphy, T. K., & Storch, E. A. (2015). Frequency and clinical correlates of sleep-related problems among anxious youth with autism sepctrum disorders. Child Psychiatry and Human Development, 46, 558–566. doi:10.1007/s10578-014-0496-9. Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995). Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. Journal of Autism and Developmental Disorders, 25(6), 641–654. Pagan, C., Delorme, R., Callebert, J., Goubran-Botros, H., Amsellem, F., Drouot, X., et al. (2014). The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational Psychiatry, 4, e479. doi:10.1038/tp.2014.120. Pandi-Perumal, S. R., Smits, M., Spence, W., Srinivasan, V., Cardinali, D. P., Lowe, A. D., et al. (2007a). Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, 31(1), 1–11. doi:10.1016/j.pnpbp.2006.06.020. Pandi-Perumal, S. R., Srinivasan, V., Maestroni, G. J., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006). Melatonin: Nature’s most versatile biological signal? FEBS J, 273(13), 2813–2838, doi:10.1111/j.1742-4658.2006.05322.x. Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., & Cardinali, D. P. (2007b). Role of the melatonin system in the control of sleep: Therapeutic implications. CNS Drugs, 21(12), 995–1018. Papp, M., Litwa, E., Gruca, P., & Mocaer, E. (2006). Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behavioural Pharmacology, 17(1), 9–18. Patzold, L. M., Richdale, A. L., & Tonge, B. J. (1998). An investigation into sleep characteristics of children with autism and Asperger’s disorder. Journal of Paediatrics and Child Health, 34, 528–533. Richdale, A. L. (1999). Sleep problems in autism: Prevalence, cause, and intervention. Developmental Medicine and Child Neurology, 41, 60–66. Richdale, A. L., & Schreck, K. A. (2009). Sleep problems in autism spectrum disorders: Prevalence, nature & possible biopsychosocial aetiologies. Sleep Medicine Reviews, 13(6), 403–411. Ritvo, E., Ritvo, R., Yuwiler, A., Brothers, A., Freeman, B., & Plotkin, S. (1993). Elevated daytime melatonin concentrations in autism: A pilot study. European Child & Adolescent Psychiatry, 2(2), 75–78. doi:10.1007/bf02098862. Robillard, R., Naismith, S. L., Rogers, N. L., Scott, E. M., Ip, T. K., Hermens, D. F., et al. (2013). Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. European Psychiatry, 28(7), 412–416. doi:10.1016/j.eurpsy.2013.04.001. Rubin, R. T., Heist, E., McGeoy, S. S., Hanada, K., & Lesser, I. (1992). Neuroendocrine aspects of primary endogenous depression: Xi. serum melatonin measures in patients and matched control subjects. Archives of General Psychiatry, 49(7), 558–567. doi:10.1001/archpsyc.1992.01820070052008. Salti, R., Galluzzi, F., Bindi, G., Perfetto, F., Tarquini, R., Halberg, F., et al. (2000). Nocturnal melatonin patterns in children. Journal of Clinical Endocrinology and Metabolism, 85, 2137–2144. Spielberger, C. D., Gorsuch, R. L., Lushene, R., Vagg, P. R., & Jacobs, G. A. (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press. Tordjman, S., Anderson, G. M., Bellissant, E., Botbol, M., Charbuy, H., Camus, F., … Touitou, Y. (2012). Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder. Psychoneuroendocrinology, 37, 1990–1997. doi:10.1016/j.psyneuen.2012.04.013. Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., & Touitou, Y. (2005). Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry, 57(2), 134–138. doi:10.1016/j.biopsych.2004.11.003. Tsaousis, I. (2010). Circadian preferences and personality traits: A meta-analysis. European Journal of Personality, 24(4), 356–373. doi:10.1002/per.754. von Bahr, C., Ursing, C., Yasui, N., Tybring, G., Bertilsson, L., & Röjdmark, S. (2000). Fluvoxamine but not citalopram increases serum melatonin in healthy subjects—an indication that cytochrome P 450 CYP1A2 and CYP2C19 hydroxylate melatonin. European Journal of Clinical Pharmacology, 56(2), 123–127. doi:10.1007/s002280050729. Voultsios, A., Kennaway, D. J., & Dawson, D. (1997). Salivary melatonin as a circadian phase marker: Validation and comparison to plasma melatonin. Journal of Biological Rhythms, 12(5), 457–466. Wasdell, M. B., Jan, J. E., Bomben, M. M., Freeman, R. D., Rietveld, W. J., Tai, J., et al. (2008). A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. Journal of Pineal Research, 44, 57–64. doi:10.1111/j.1600-079X.2007.00528.x. Wechsler, D. (1999). WASI Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation. Wechsler, D. (2008). WAIS-IV Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation. Wiggs, L., & Stores, G. (2004). Sleep patterns and sleep disorders in children with autistic spectrum disorders: Insights using parent report and actigraphy. Developmental Medicine & Child Neurology, 46(6), 372–380. doi:10.1017/S0012162204000611. Woodbury-Smith, M. R., Robinson, J., Wheelwright, S., & Baron-Cohen, S. (2005). Screening adults for Asperger Syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. Journal of Autism and Developmental Disorders, 35(3), 331–335. Zawilska, J. B., Skene, D. J., & Arendt, J. (2009). Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacological Reports, 61(3), 383–410.