Assembly and Function of Type III Secretory Systems

Annual Review of Microbiology - Tập 54 Số 1 - Trang 735-774 - 2000
Guy R. Cornelis1,2, Frédérique Van Gijsegem1,2
1Laboratoire Associé de l'INRA (France), Department of Plant Genetics—VIB, Universiteit Gent, B-9000 Gent, Belgium;
2Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Université Catholique de Louvain, B-1200 Brussels, Belgium

Tóm tắt

▪ Abstract  Type III secretion systems allow Yersinia spp., Salmonella spp., Shigella spp., Bordetella spp., and Pseudomonas aeruginosa and enteropathogenic Escherichia coli adhering at the surface of a eukaryotic cell to inject bacterial proteins across the two bacterial membranes and the eukaryotic cell membrane to destroy or subvert the target cell. These systems consist of a secretion apparatus, made of ∼25 proteins, and an array of proteins released by this apparatus. Some of these released proteins are “effectors,” which are delivered into the cytosol of the target cell, whereas the others are “translocators,” which help the effectors to cross the membrane of the eukaryotic cell. Most of the effectors act on the cytoskeleton or on intracellular-signaling cascades. A protein injected by the enteropathogenic E. coli serves as a membrane receptor for the docking of the bacterium itself at the surface of the cell. Type III secretion systems also occur in plant pathogens where they are involved both in causing disease in susceptible hosts and in eliciting the so-called hypersensitive response in resistant or nonhost plants. They consist of 15–20 Hrp proteins building a secretion apparatus and two groups of effectors: harpins and avirulence proteins. Harpins are presumably secreted in the extracellular compartment, whereas avirulence proteins are thought to be targeted into plant cells. Although a coherent picture is clearly emerging, basic questions remain to be answered. In particular, little is known about how the type III apparatus fits together to deliver proteins in animal cells. It is even more mysterious for plant cells where a thick wall has to be crossed. In spite of these haunting questions, type III secretion appears as a fascinating trans-kingdom communication device.

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Tài liệu tham khảo

10.1046/j.1365-2958.1999.01558.x

10.1046/j.1365-2958.1996.415946.x

10.1128/jb.179.18.5655-5662.1997

10.1094/MPMI.1997.10.5.580

10.1073/pnas.96.22.12839

10.1126/science.278.5340.1140

10.1046/j.1365-2958.1999.01254.x

10.1002/j.1460-2075.1994.tb06292.x

10.1007/BF01874789

10.1094/MPMI-8-0484

10.1046/j.1365-2958.1999.01527.x

10.1093/emboj/16.10.2730

10.1083/jcb.147.3.683

Bogdanove AJ, 1998, J. Bacteriol., 180, 2244, 10.1128/JB.180.8.2244-2247.1998

10.1073/pnas.95.3.1325

Boland A, 1998, Infect. Immun., 66, 1878, 10.1128/IAI.66.5.1878-1884.1998

10.1002/j.1460-2075.1996.tb00904.x

10.1016/S1369-5274(99)80016-2

Boyd A, Lambermont I, Cornelis GR. 2000. Competition between the Yops ofYersinia enterocoliticafor delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE.J. Bacteriol. In press

10.1046/j.1365-2958.1998.00691.x

10.1073/pnas.95.26.15849

Charkowski AO, 1998, J. Bacteriol., 180, 5211, 10.1128/JB.180.19.5211-5217.1998

10.1002/j.1460-2075.1996.tb00759.x

10.1046/j.1365-2958.1997.3831750.x

Collazo CM, 1996, Infect. Immun., 64, 3524, 10.1128/iai.64.9.3524-3531.1996

Cornelis GR, 1998, Microbiol. Mol. Biol. Rev., 62, 1315, 10.1128/MMBR.62.4.1315-1352.1998

10.1046/j.1365-2958.1997.2731623.x

10.1046/j.1365-2958.1998.01110.x

10.1094/MPMI.1998.11.7.698

10.1046/j.1365-2958.1998.00798.x

Deng WL, 1999, J. Bacteriol., 181, 2298, 10.1128/JB.181.7.2298-2301.1999

10.1094/MPMI.1999.12.6.556

Ebel F, 1996, Infect. Immun., 64, 4472, 10.1128/iai.64.11.4472-4479.1996

10.1046/j.1365-2958.1998.01046.x

10.1046/j.1365-2958.1999.01559.x

10.1016/1369-5266(88)80048-7

10.1046/j.1365-2958.1997.4891851.x

Finck-Barbancon V, 1998, J. Bacteriol., 180, 6224, 10.1128/JB.180.23.6224-6231.1998

10.1146/annurev.py.09.090171.001423

10.1046/j.1365-2958.1998.00973.x

10.1046/j.1365-2958.1998.01144.x

10.1046/j.1365-2958.1999.01372.x

10.1046/j.1365-2958.1997.5411905.x

10.1111/j.1365-2958.1995.tb02426.x

Fu YX, 1998, J. Bacteriol., 180, 3393, 10.1128/JB.180.13.3393-3399.1998

10.1038/45829

10.1016/S1360-1385(97)89544-1

10.1126/science.284.5418.1322

10.1016/S0014-5793(98)00534-1

10.1046/j.1365-2958.1997.6442015.x

10.1016/S0962-8924(98)01418-4

10.1105/tpc.8.7.1095

10.1046/j.1365-2958.2000.01870.x

10.1046/j.1365-2958.1996.5251051.x

10.1002/j.1460-2075.1996.tb00968.x

10.1073/pnas.95.17.10206

10.1016/S0092-8674(00)81442-7

10.1073/pnas.94.18.9887

10.1073/pnas.95.5.2574

10.1046/j.1365-2958.1998.00727.x

10.1093/emboj/18.18.4926

10.1016/0092-8674(93)90354-S

10.1046/j.1365-2958.1998.01047.x

10.1038/356172a0

10.1073/pnas.96.5.2396

10.1074/jbc.273.49.32895

Hobbie S, 1997, J. Immunol., 159, 5550, 10.4049/jimmunol.159.11.5550

Hueck CJ, 1998, Microbiol. Mol. Biol. Rev., 62, 379, 10.1128/MMBR.62.2.379-433.1998

10.1046/j.1365-2958.1998.01019.x

10.1046/j.1365-2958.1998.00992.x

Iriarte M, 1999, J. Bacteriol., 181, 675, 10.1128/JB.181.2.675-680.1999

Jackson MW, 1998, J. Bacteriol., 180, 4912, 10.1128/JB.180.18.4912-4921.1998

10.1073/pnas.96.19.10875

10.1073/pnas.92.17.7996

Jones MA, 1998, Infect. Immun., 66, 5799, 10.1128/IAI.66.12.5799-5804.1998

10.1038/7716

10.1128/jb.177.14.3965-3971.1995

10.1111/j.1365-2958.1996.tb02571.x

10.1038/346385a0

10.1094/MPMI-3-112

10.1016/S0092-8674(00)80437-7

10.1006/mpat.1999.0307

Kim JF, 1998, J. Bacteriol., 180, 5203, 10.1128/JB.180.19.5203-5210.1998

10.1094/MPMI.1998.11.12.1247

10.1093/emboj/17.8.2166

10.1046/j.1365-2958.1997.6141981.x

10.1126/science.280.5363.602

10.1146/annurev.phyto.34.1.153

10.1073/pnas.93.26.15497

10.1126/science.278.5343.1635

10.1146/annurev.phyto.35.1.129

10.1094/MPMI-7-0508

10.1016/S1369-5266(99)80049-1

McGuffie EM, 1998, Infect. Immun., 66, 2607, 10.1128/IAI.66.6.2607-2613.1998

10.1046/j.1365-313X.1998.00106.x

10.1016/0092-8674(94)90260-7

10.1046/j.1365-2958.1999.01651.x

Michiels T, 1990, Infect. Immun., 58, 2840, 10.1128/iai.58.9.2840-2849.1990

10.1073/pnas.94.23.12638

Minamino T, 1999, J. Bacteriol., 181, 1388, 10.1128/JB.181.5.1388-1394.1999

10.1073/pnas.94.19.10385

10.1046/j.1365-2958.1999.01403.x

10.1094/MPMI.1997.10.4.462

10.1046/j.1365-2958.1999.01154.x

10.1046/j.1365-2958.1999.01537.x

10.1094/MPMI.1997.10.5.677

10.1073/pnas.95.24.14057

10.1073/pnas.93.15.7800

10.1126/science.285.5435.1920

Payne PL, 1998, J. Bacteriol., 180, 3882, 10.1128/JB.180.15.3882-3890.1998

10.1046/j.1365-2958.1999.01359.x

10.1046/j.1462-5822.1999.00013.x

10.1093/emboj/16.9.2307

10.1111/j.1365-2958.1995.mmi_18010135.x

10.1046/j.1365-2958.1999.01408.x

10.1126/science.273.5279.1231

10.1094/MPMI-9-0252

10.1073/pnas.94.7.3459

10.1111/j.1365-2958.1990.tb00635.x

Rosqvist R, 1991, Infect. Immun., 59, 4562, 10.1128/iai.59.12.4562-4569.1991

10.1002/j.1460-2075.1995.tb00092.x

10.1002/j.1460-2075.1994.tb06341.x

10.1073/pnas.96.16.9368

10.1084/jem.187.7.1069

Sarker MR, 1998, J. Bacteriol., 180, 1207, 10.1128/JB.180.5.1207-1214.1998

10.1046/j.1365-2958.1998.00851.x

Schulte R, 1996, Infect. Immun., 64, 2106, 10.1128/iai.64.6.2106-2113.1996

10.1126/science.274.5295.2063

10.1046/j.1365-2958.1998.01135.x

10.1073/pnas.92.26.11998

10.1111/j.1365-2958.1994.tb02191.x

10.1046/j.1365-2958.2000.02026.x

Starnbach MN, 1994, J. Immunol., 153, 1603, 10.4049/jimmunol.153.4.1603

10.1046/j.1365-2958.1998.00918.x

10.1094/Phyto-81-802

10.1128/jb.178.15.4661-4669.1996

10.1126/science.274.5295.2060

10.1093/emboj/18.23.6793

Tsolis RM, 1999, Infect. Immun., 67, 6385, 10.1128/IAI.67.12.6385-6393.1999

10.1093/emboj/18.14.3924

van Dijk K, 1999, J. Bacteriol., 181, 4790, 10.1128/JB.181.16.4790-4797.1999

10.1111/j.1365-2958.1995.tb02284.x

10.1046/j.1365-2958.2000.01851.x

10.1016/S0092-8674(00)81825-5

10.1093/emboj/16.10.2717

10.1016/S1369-5274(99)80009-5

10.1093/emboj/18.12.3249

10.1046/j.1365-2958.1998.00920.x

10.1099/00221287-143-3-693

10.1046/j.1365-2958.1999.01303.x

10.1046/j.1365-2958.1998.00771.x

Warawa J, 1999, Infect. Immun., 67, 5538, 10.1128/IAI.67.10.5538-5540.1999

10.1002/j.1460-2075.1995.tb07243.x

10.1073/pnas.91.22.10493

10.1111/j.1365-2958.1993.tb01209.x

10.1126/science.1621099

10.1073/pnas.040570097

10.1111/j.1365-2958.1996.tb02645.x

10.1046/j.1365-2958.1998.00782.x

10.1073/pnas.95.23.13899

10.1094/MPMI-9-0105

10.1073/pnas.96.11.6456

10.1126/science.283.5410.2092

10.1094/MPMI.1998.11.8.824

10.1074/jbc.274.41.29289

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Annual Review of Microbiology

Tập 54 Số 1

735-774

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