Approaching the structure of human VDAC1, a key molecule in mitochondrial cross-talk
Tóm tắt
The voltage dependent anion-channel, VDAC, is the major constitutive protein of the outer membrane of mitochondria. Functionally, VDAC is involved in the exchange of small metabolites over the mitochondrial outer membrane and supports enzymes of the cytoplasm with energy precursors i.e. ATP. Moreover, the channel alone or in complex with proteins of the inner mitochondrial membrane or the intermembrane space provides a basis for docking of cytosolic proteins which can regulate outer membrane permeability in several ways. Structurally, this channel has a bacterial origin by evolution and partly resembles bacterial porin functions. However, the structure seems more complex as a variety of interactions on both channel sides can occur. Therefore, our work described is aiming to determine the structure of VDAC at atomic resolution and together with functional data to understand better how this channel can carry out such a variety of differing functions.
Tài liệu tham khảo
Bernardi P, Forte M (2007) Novartis Found Symp 287:157–164
Bolender N, Sickmann A, Wagner R, Meisinger C, Pfanner N (2008) EMBO Rep 9:42–49
Bose M, Whittal RM, Gairola CG, Bose HS (2008) Toxicol Appl Pharmacol 227:284–290
Bowen KA, Tam K, Colombini M (1985) J Membr Biol 86:51–59
Brdiczka D, Beutner G, Rück A, Dolder M, Wallimann T (1998) Biofactors 8:235–242
Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (2003) Science 301:513–517
Desai MK, Mishra RN, Verma D, Nair S, Sopory SK, Reddy MK (2006) Plant Physiol Biochem 44:483–493
Dolder M, Zeth K, Tittmann P, Gross H, Welte W, Wallimann T (1999) J Struct Biol 127:64–71
Galluzzi L, Kepp O, Tajeddine N, Kroemer G (2008) Oncogene. In press
Grimm S, Brdiczka D (2007) Apoptosis 12:841–855
Guo XW, Smith PR, Cognon B, D’Arcangelis D, Dolginova E, Mannella CA (1995) J Struct Biol 114:41–59
Komarov AG, Deng D, Craigen WJ, Colombini M (2005) Biophys J 89:3950–3959
Koppel DA, Kinnally KW, Masters P, Forte M, Blachly-Dyson E, Mannella CA (1998) J Biol Chem 273:13794–13800
Malia TJ, Wagner G (2007) Biochemistry 46:514–525
Mannella CA (1998a) J Struct Biol 121:207–218
Mannella CA (1998b) J Struct Biol 121:207–218
Mazzoni C, Falcone C (2008) BBA 1783:1320–1327
Minetti CA, Tai JY, Blake MS, Pullen JK, Liang SM, Remeta DP (1997) J Biol Chem 272:10710–10720
Nahon E, Israelson A, Abu-Hamad S, Varda SB (2006) FEBS Lett 579:5105–5110
Pastorino JG, Hoek JB (2003) Curr Med Chem 10:1535–1551
Rostovtseva TK, Antonsson B, Suzuki M, Youle RJ, Colombini M, Bezrukov SM (2004) J Biol Chem 279:13575–13583
Salinas T, Duchêne AM, Delage L, Nilsson S, Glaser E, Zaepfel M, Maréchal-Drouard L (2006) Proc Nat Acad Sci 103:18362–18367
Schwertz H, Carter JM, Abdudureheman M, Russ M, Buerke U, Schlitt A, Müller-Werdan U, Prondzinsky R, Werdan K, Buerke M (2007) Proteomics 7:4579–4588
Shao L, Kinnally KW, Mannella CA (1996) Biophys J 71:778–786
Sukumaran S, Hauser K, Maier E, Benz R, Mäntele W (2006) Biochemistry 45:3972–3980
Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR (2007) Nature 447:864–868
Young MJ, Bay DC, Hausner G, Court DA (2007) BMC Evol Biol 7:31