Application of the Ferguson principle to the antibacterial activity of mono- and multi-component solutions of quaternary ammonium surface-active agents

Journal of Pharmacy and Pharmacology - Tập 22 Số Supplement_1 - Trang 157S-162S - 1970
H H Laycock1, B A Mulley1
1Postgraduate School of Studies in Pharmacy, University of Bradford, Bradford 7, U.K.

Tóm tắt

Abstract Critical micelle concentrations (cmc) have been measured by the surface tension method for binary mixtures of dodecyltrimethyl-ammonium bromide with tetradecyltrimethylammonium bromide, binary mixtures of C14/C16 homologues, a ternary mixture of the C12/C14/C16 compounds and additionally for each component individually. The antibacterial activities of the systems against Escherichia coli were determined by a British Standard Method (B.S. 3286: 1960). Thermodynamic activities of the solutions at two survivor levels, calculated from the physical and biological measurements, were sufficiently constant to sustain the Ferguson principle for these micelle-forming antibacterial agents. A theoretical treatment of micelle formation for multi-component solutions of surfactants gave cmc’s by calculation in close agreement with the experimentally determined values. The purity and composition of the surfactants was determined by gas liquid chromatography.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Journal of Pharmacy and Pharmacology

Tập 22 Số Supplement_1

157S-162S

Thông tin tác giả