Application of Microdialysis in Pharmacokinetic Studies

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citation_journal_title=Antimicrob. Agents Chemother.; citation_title=Penetration of zidovudine and 3′fluoro-3′-deoxythymidine into the brain, muscle tissue, and veins in Cynomolgus monkeys: relation to antiviral action; citation_author=E. Ljungdahl-Stahle, E. Guzenda, D. Bottiger, B. Wahren, B. Oberg, L. Stahle; citation_volume=36; citation_publication_date=1992; citation_pages=2418-2422; citation_id=CR87

citation_journal_title=Antimicrob. Agents Chemother.; citation_title=Pharmacokinetics and distribution over the blood-brain barrier of two acyclic guanosine analogs in rats, studied by microdialysis; citation_author=L. Stahle, B. Oberg; citation_volume=36; citation_publication_date=1992; citation_pages=339-342; citation_id=CR88

citation_journal_title=Pharm. Res.; citation_title=The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain; citation_author=E. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof, A. G. de Boer, D. D. Breimer; citation_volume=12; citation_publication_date=1995; citation_pages=1924-1931; citation_id=CR89

D. Devineni, A. Klein-Szanto, and J. M. Gallo. In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2) bearing rats, in press, Cancer Chemother. Pharmacol.

citation_journal_title=Cancer Res.; citation_title=Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470; citation_author=D. Devineni, A. Klein-Szanto, J. M. Gallo; citation_volume=56; citation_publication_date=1996; citation_pages=1983-1987; citation_id=CR91

citation_journal_title=Biochem. Pharmacol.; citation_title= In vivo evidence for ATP-dependent and P-glycoprotein mediated transport of cyclosporin A at the blood-brain barrier; citation_author=A. Sakata, I. Tamai, K. Kawazu, Y. Deguchi, T. Ohnishi, A. Saheki, A. Tsuji; citation_volume=48; citation_publication_date=1994; citation_pages=1989-1992; citation_id=CR92

citation_journal_title=Biochem. Pharmacol.; citation_title=Modulation effects of cyclosporine on etoposide pharmacokinetics and CNS distribution in the rat utilizing microdialysis; citation_author=D. E. Burgio, M. P. Gosland, P. J. McNamara; citation_volume=51; citation_publication_date=1996; citation_pages=987-992; citation_id=CR93

citation_journal_title=Neurology; citation_title=Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysis; citation_author=R. D. Scheyer, M. J. During, D. D. Spencer, J. A. Cramer, R. H. Mattson; citation_volume=44; citation_publication_date=1994; citation_pages=1469-1472; citation_id=CR94

citation_journal_title=Epilepsy Res.; citation_title=Phenytoin concentrations in the human brain: an in vivo microdialysis study; citation_author=R. D. Scheyer, M. J. During, J. M. Hochholzer, D. D. Spencer, J. A. Cramer, R. H. Mattson; citation_volume=18; citation_publication_date=1994; citation_pages=227-232; citation_id=CR95

citation_journal_title=Thera. Drug Monit.; citation_title=Monitoring free extracellular valproic acid by microdialysis in epileptic patients; citation_author=L. Stahle, C. Alm, B. Ekquist, B. Lundquist, T. Tomson; citation_volume=18; citation_publication_date=1996; citation_pages=14-18; citation_id=CR96

citation_journal_title=J. Pharm. Pharmacol.; citation_title=The extracellular concentration of the anti-epileptic drug valproate in the rat brain as determined with microdialysis and an automated HPLC procedure; citation_author=J. H. Wolf, L. Veenma-Van der Duin, J. Korf; citation_volume=43; citation_publication_date=1991; citation_pages=101-106; citation_id=CR97

citation_journal_title=Pharm. Res.; citation_title=Assessment of valproic acid serum-cerebrospinal fluid transport by microdialysis; citation_author=P. L. Golden, K. R. Brouwer, G. M. Pollack; citation_volume=10; citation_publication_date=1993; citation_pages=1765-1771; citation_id=CR98

citation_journal_title=Epilepsy Res.; citation_title=Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate; citation_author=D. F. Welty, G. P. Schielke, M. G. Vartanian, C. P. Taylor; citation_volume=16; citation_publication_date=1993; citation_pages=175-181; citation_id=CR99

citation_journal_title=Pharm. Res.; citation_title=The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach; citation_author=Y. Wang, D. F. Welty; citation_volume=13; citation_publication_date=1996; citation_pages=398-403; citation_id=CR100

citation_journal_title=Pharm. Res.; citation_title=Study on brain interstitial fluid distribution and blood-brain barrier transport of baclofen in rats by microdialysis; citation_author=Y. Deguchi, K. Inabe, K. Tomiyasu, K. Nozawa, S. Yamada, R. Kimura; citation_volume=12; citation_publication_date=1995; citation_pages=1838-1844; citation_id=CR101

citation_journal_title=Jap. J. Psych. Neuro.; citation_title=Carbamazepine and carbamazepine-10, 11-epoxide concentrations in rat brain and blood evaluated by in vivo microdialysis; citation_author=R. Takahashi, M. Hagiwara, M. Watabe, R. Kan, Y. Takahashi; citation_volume=47; citation_publication_date=1993; citation_pages=293-294; citation_id=CR102

citation_journal_title=J. Pharmacol. Exper. Ther.; citation_title=Brain, liver, and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats: a quantitative microdialysis study; citation_author=K. Van Belle, S. Sarre, G. Ebinger, Y. Michotte; citation_volume=272; citation_publication_date=1995; citation_pages=1217-1222; citation_id=CR103

citation_journal_title=J. Neurosci. Methods; citation_title= In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference technique; citation_author=K. Van Belle, T. Dzeka, S. Sarre, G. Ebinger, Y. Michotte; citation_volume=49; citation_publication_date=1993; citation_pages=167-173; citation_id=CR104

citation_journal_title=Res Commun. Mol. Path. Pharmacol.; citation_title=Pharmacokinetic study of trimethadione and its metabolite in blood, liver and brain by microdialysis in conscious, unrestrained rats; citation_author=N. Kurata, M. Inagaki, M. Iwase, Y. Nishimura, Y. Kiuchi, Y. Yamazaki, S. Kobayashi, K Oguchi, E. Uchida, H. Yasuhara; citation_volume=89; citation_publication_date=1995; citation_pages=45-56; citation_id=CR105

citation_journal_title=Life Sciences; citation_title=Drug distribution studies with microdialysis: I. Tissue dependent difference in recovery between caffeine and theophylline; citation_author=L. Stahle; citation_volume=49; citation_publication_date=1991; citation_pages=1835-1842; citation_id=CR106

citation_journal_title=Life Sciences; citation_title=Drug distribution studies with microdialysis II. Caffeine and theophylline in blood, brain and other tissues in rats; citation_author=L. Stahle, S. Segersvard, U. Ungerstedt; citation_volume=49; citation_publication_date=1991; citation_pages=1843-1852; citation_id=CR107

citation_journal_title=Chem. Pharm. Bull.; citation_title=Application of microdialysis for study of caffeine distribution into brain and cerebrospinal fluid in rats; citation_author=T. Nakazono, T. Murakami, S. Sakai, Y. Higashi, N. Yata; citation_volume=40; citation_publication_date=1992; citation_pages=2510-2515; citation_id=CR108

citation_journal_title=Toxicol. Appl. Pharmacol.; citation_title=Aluminum distribution into brain and liver of rats and rabbits following intravenous aluminum lactate or citrate: a microdialysis study; citation_author=R. A. Yokel, V. Lidums, P. J. McNamara, U. Ungerstedt; citation_volume=107; citation_publication_date=1991; citation_pages=153-163; citation_id=CR109

citation_journal_title=Toxicology; citation_title=Aluminum mobilization by desferrioxamine assessed by microdialysis of the blood, liver and brain; citation_author=R. A. Yokel, V. Lidums, U. Ungerstedt; citation_volume=66; citation_publication_date=1991; citation_pages=313-324; citation_id=CR110

citation_journal_title=Toxicology; citation_title=Evidence for energy-dependent transport of aluminum out of brain extracellular fluid; citation_author=D. D. Allen, C. Orvig, R. A. Yokel; citation_volume=98; citation_publication_date=1995; citation_pages=31-39; citation_id=CR111

citation_journal_title=Pharm. Res.; citation_title=Distribution of tacrine across the blood-brain barrier in awake, freely moving rats using in vivo microdialysis sampling; citation_author=M. Telting-Diaz, C. E. Lunte; citation_volume=10; citation_publication_date=1993; citation_pages=44-48; citation_id=CR112

R. C. Brundage. Investigation of the brain distribution and presystemic metabolism of tacrine and selected metabolites using microdialysis of brain and blood. Ph.D. dissertation, University of Minnesota (1996).

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citation_journal_title=Pharm. Res.; citation_title=Microdialysis sampling to determine the pharmacokinetics of unbound SDZ-ICM 567 in blood and brain in awake, freely-moving rats; citation_author=M. J. Alonso, A. Bruelisauer, P. Misslin, M. Lemaire; citation_volume=12; citation_publication_date=1995; citation_pages=291-294; citation_id=CR115

citation_journal_title=Br. J. Pharmacol.; citation_title=Measurement and pharmacokinetic analysis of imipramine and its metabolite by brain microdialysis; citation_author=Y. Sato, S. Shibanoki, M. Sugahara, K. Ishikawa; citation_volume=112; citation_publication_date=1994; citation_pages=625-629; citation_id=CR116

citation_journal_title=J. Chromatog. B.; citation_title=High-performance liquid chromatographic analysis of (s)-a-amino-5-phosphonomethly[1,1′-biphenyl]-3-propanoic acid (EAB 515) in brain and blood microdialysate (on-line) and in plasma ultrafiltrate of freely moving rats; citation_author=B. K. Malhotra, M. Lemaire, J. F. Brouillard, R. J. Sawchuk; citation_volume=679; citation_publication_date=1996; citation_pages=167-176; citation_id=CR117

B. K. Malhotra, R. C. Brundage, M. Lemaire, and R. J. Sawchuk. Modeling the route of administration-based enhancement in the brain delivery of EAB 515, studied by microdialysis. J. Drug Targeting in press (1997).

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citation_journal_title=Life Sci.; citation_title=An improved method to calculate adipose tissue interstitial substrate recovery for microdialysis studies; citation_author=P. A. Jansson, T. Veneman, N. Nurjhan, J. Gerich; citation_volume=54; citation_publication_date=1994; citation_pages=1621-1624; citation_id=CR122

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citation_journal_title=Acta Ophthalmologica; citation_title=Intraocular microdialysis with permanently implanted probes in rabbit; citation_author=J. Waga, A. Ohta, B. Ehinger; citation_volume=69; citation_publication_date=1991; citation_pages=618-624; citation_id=CR134

citation_journal_title=Graefes Archive for Clinical & Experimental Ophthalmology; citation_title=A removable ocular microdialysis system for measuring vitreous biogenic amines; citation_author=N. Stempels, M. J. Tassignon, S. Sarre; citation_volume=231; citation_publication_date=1993; citation_pages=651-655; citation_id=CR135

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citation_journal_title=Graefes Archive for Clinical & Experimental Ophthalmology; citation_title=Passage of drugs through different intraocular microdialysis membranes; citation_author=J. Waga, B. Ehinger; citation_volume=233; citation_publication_date=1995; citation_pages=31-37; citation_id=CR137

citation_journal_title=J. Ocular Pharmacol. Therap.; citation_title=Vitreous disposition of two acycloguanosine antivirals in the albino and pigmented rabbit models: a novel ocular microdialysis technique; citation_author=P. M. Hughes, R. Krishnamoorthy, A. K. Mitra; citation_volume=12; citation_publication_date=1996; citation_pages=209-224; citation_id=CR138

citation_journal_title=Journal of Cardiovascular Pharmacology; citation_title=Allopurinol: kinetics, inhibition of xanthine oxidase activity, and protective effect in ischemic-reperfused canine heart as studied by cardiac microdialysis; citation_author=A. I. Kuzmin, O. V. Tskitishvili, L. I. Serebryakova, V. I. Kapelko, I. V. Majorova, O. S. Medvedev; citation_volume=25; citation_publication_date=1995; citation_pages=564-571; citation_id=CR139

citation_journal_title=J. Chromatog.; citation_title=Measurements by microdialysis of free tissue concentrations of propranolol; citation_author=P. Lonnroth, J. Carlsten, L. Johnson, U. Smith; citation_volume=568; citation_publication_date=1991; citation_pages=419-425; citation_id=CR140

citation_journal_title=J. Pharmacol Toxicolog. Methods; citation_title=Pharmacokinetic measurement of drugs in lung epithelial lining fluid by microdialysis: aminoglycoside antibiotics in rat bronchi; citation_author=E. J. Eisenberg, P. Conzentino, W. M. Eickhoff, K. C. Cundy; citation_volume=29; citation_publication_date=1993; citation_pages=93-98; citation_id=CR141

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citation_journal_title=Cancer Chemotherapy & Pharmacology; citation_title=Evaluation of methotrexate tissue exposure by in situ microdialysis in a rat model; citation_author=O. Ekstrom, A. Andersen, D. J. Warren, K. E. Giercksky, L. Slordal; citation_volume=34; citation_publication_date=1994; citation_pages=297-301; citation_id=CR143

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citation_journal_title=Brit. J. Cancer; citation_title=Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis; citation_author=B. Blochl-Daum, M. Muller, V. Meisinger, H. G. Eichler, A. Fassolt, H. Pehamberger; citation_volume=73; citation_publication_date=1996; citation_pages=920-924; citation_id=CR161

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citation_journal_title=Diabetes; citation_title=Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin; citation_author=P. A. Jansson, J. P. Fowelin, H. P. von Schenck, U. P. Smith, P. N. Lonnroth; citation_volume=42; citation_publication_date=1993; citation_pages=1469-73; citation_id=CR168

citation_journal_title=Life Sci.; citation_title=Drug distribution studies with microdialysis. III: Extracellular concentration of caffeine in adipose tissue in man; citation_author=L. Stahle, P. Arner, U. Ungerstedt; citation_volume=49; citation_publication_date=1991; citation_pages=1853-8; citation_id=CR169

citation_journal_title=Clin. Pharmacol. Ther.; citation_title=Application of microdialysis to clinical pharmacokinetics in humans; citation_author=M. Muller, R. Schmid, A. Georgopoulos, A. Buxbaum, C. Wasicek, H. G. Eichler; citation_volume=57; citation_publication_date=1995; citation_pages=371-380; citation_id=CR170

citation_journal_title=Naunyn-Schmied. Arch Pharmacol.; citation_title=Theophylline kinetics in peripheral tissues in vivo in humans; citation_author=M. Muller, B. V. Osten, R. Schmid, E. Piegler, I. Gerngross, H. Buchegger, H. G. Eichler; citation_volume=352; citation_publication_date=1995; citation_pages=438-441; citation_id=CR171

citation_journal_title=Clin. Pharmacol. Ther.; citation_title=Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes; citation_author=K. M. Hargreaves, A. Costello; citation_volume=48; citation_publication_date=1990; citation_pages=168-178; citation_id=CR172

citation_journal_title=Kidney International; citation_title=Urea kinetics during hemodialysis measured by microdialysis—a novel technique; citation_author=G. S. Metry, P. O. Attman, P. Lonnroth, S. N. Beshara, M. Aurell; citation_volume=44; citation_publication_date=1993; citation_pages=622-629; citation_id=CR173

citation_journal_title=J. Invest. Derm.; citation_title=Microdialysis in cutaneous pharmacology: kinetic analysis of transdermally delivered nicotine; citation_author=L. Hegemann, C. Forstinger, B. Partsch, I. Lagler, S. Krotz, K. Wolff; citation_volume=104; citation_publication_date=1995; citation_pages=839-843; citation_id=CR174

citation_journal_title=Acta Dermato-Venereologica; citation_title=Ethanol absorption across human skin measured by in vivo microdialysis technique; citation_author=C. Anderson, T. Andersson, M. Molander; citation_volume=71; citation_publication_date=1991; citation_pages=389-393; citation_id=CR175

citation_journal_title=J. Invest. Derm.; citation_title=Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging; citation_author=C. Anderson, T. Andersson, K. Wardell; citation_volume=102; citation_publication_date=1994; citation_pages=807-811; citation_id=CR176

citation_journal_title=J. Appl. Physiol.; citation_title=Microdialysis probe for transcutaneous monitoring of ethanol and glucose in humans; citation_author=J. de Boer, H. Plijter-Groendijk, J. Korf; citation_volume=75; citation_publication_date=1993; citation_pages=2825-2830; citation_id=CR177

citation_journal_title=Intensive Care Med.; citation_title=Chemical monitoring of intensive care patients using intravenous microdialysis; citation_author=H. Stjernstrom, T. Karlsson, U. Ungerstedt, L. Hillered; citation_volume=19; citation_publication_date=1993; citation_pages=423-428; citation_id=CR178

citation_journal_title=Stroke; citation_title=Intracerebral microdialysis. In vivo study of an acute focal ischemic model of the human brain; citation_author=R. Kanthan, A. Shuaib, R. Griebel, H Miyashita; citation_volume=26; citation_publication_date=1995; citation_pages=870-873; citation_id=CR179

citation_title= neurochemistry of the conscious human brain: intrahippocampal microdialysis in epilepsy; citation_inbook_title=Microdialysis in the Neurosciences. Techniques in the Behavioral and Neural Sciences; citation_publication_date=1991; citation_pages=425-442; citation_id=CR180; citation_author=M. J. During; citation_publisher=Elsevier

citation_journal_title=J. Neurosci. Methods; citation_title=The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbens; citation_author=L. H. Parsons, A. D. Smith, J. B. Justice; citation_volume=40; citation_publication_date=1991; citation_pages=139-147; citation_id=CR181

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