Appendicitis during the COVID-19 pandemic: lessons learnt from a district general hospital

Heather Pringle1, Urszula Donigiewicz1, Melissa-Rose Bennett1, Eleanor Walker1, George E Fowler1, Sunil K. Narang1, Susan Ball2, Robert Bethune3
1Royal Devon & Exeter Hospital, Exeter, EX2 5DW, Devon, UK
2NIHR Applied Research Collaboration, South West Peninsula (PenARC), University of Exeter Medical School, Exeter, EX1 2LU, Devon, UK
3University of Exeter Medical School, St. Luke's Campus, Heavitree Road, Exeter, EX1 2LU, Devon, UK

Tóm tắt

Abstract Background The COVID-19 pandemic dramatically influenced the delivery of healthcare. In line with the UK Royal Colleges’ advice the management of acute appendicitis (AA) changed with greater consideration for non-operative management (NOM) or open appendicectomy when operative management (OM) was sought. We describe our experience of the presentation, management and outcomes for these patients to inform care for future viral pandemics. Methods This retrospective, cohort study compared patients diagnosed with AA between March and July 2019 with those during the pandemic period of March to July 2020. Medical records were reviewed to obtain demographics, inflammatory markers, imaging, severity, management, histology, length of stay (LOS) and 90-day outcomes. Results There were 149 and 125 patients in the 2019 and 2020 cohorts respectively. 14 patients (9.4%) had NOM in 2019 versus 31 (24.8%) in 2020 (p = 0.001). In the 2019 operative management (OM) group 125 patients (92.6%) had laparoscopic appendicectomy versus 65 (69.1%) in 2020. 59 patients (39.6%) had a CT in 2019 versus 70 (56%) in 2020. The median LOS was 4 days in 2019 and 3 days in 2020 (p = 0.03). Two patients in each year who received NOM had treatment failure (14.3% in 2019 and 6.5% in 2020). Three patients in 2019 who received OM had treatment failure (2.2%). Of 95 patients tested for COVID-19 all but one tested negative. Conclusion During the COVID-19 pandemic there was no observed increase in severity of AA, patients had a shorter LOS and were more likely to have imaging. NOM proportionally increased with no observed change in outcomes.

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Tài liệu tham khảo

World Health Organisation. WHO announces COVID-19 outbreak a pandemic [Internet]. 2020. http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-a-pandemic. Accessed 24 May 2020.

Evison C, England N. A&E Attendances and Emergency Admissions March 2020 Statistical Commentary [Internet]. NHS England; 2020. https://www.england.nhs.uk/statistics/statistical-work-areas/ae-waiting-times-and-activity/ae-attendances-and-emergency-admissions-2019-20/. Accessed 22 Jun 2020.

Zampieri N. Effect of SARS-CoV-2 on the incidence of appendicitis: the role of quarantine. Paediatr Emerg Care. 2020;36(8):e482–3.

ASGBI, ACPGBI, AUGIS, RCS Edinburgh, RCS England, RCPSG, RCSI. Updated General Surgery Guidance on COVID-19. Griffin SM, Anderson D, Taylor J, Mealy K, Anderson I, Fearnhead N, et al., editors. undefined [Internet]. 2020. https://www.rcseng.ac.uk/-/media/files/rcs/coronavirus/3rd-update-intercollegiate-general-surgery-guidance-on-covid19-30-may.pdf. Accessed 7Apr 2020.

Saverio SD, Podda M, Simone BD, Ceresoli M, Augustin G, Gori A, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg WJES. 2020;15(1):27.

Li X, Zhang J, Sang L, Zhang W, Chu Z, Li X, et al. Laparoscopic versus conventional appendectomy–a meta-analysis of randomized controlled trials. BMC Gastroenterol. 2010;10(1):129.

Solomon CG, Flum DR. Clinical practice. Acute appendicitis–appendectomy or the “antibiotics first” strategy. New Engl J Med. 2015;372(20):1937–43.

Podda M, Gerardi C, Cillara N, Fearnhead N, Gomes CA, Birindelli A, et al. Antibiotic treatment and appendectomy for uncomplicated acute appendicitis in adults and children: a systematic review and meta-analysis. Ann Surg. 2019;270(6):1028–40.

Harnoss JC, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss JM, et al. Antibiotics versus surgical therapy for uncomplicated appendicitis. Ann Surg. 2017;265(5):889–900.

Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis. JAMA. 2015;313(23):2340.

Daabiss M. American Society of Anaesthesiologists physical status classification. Indian J Anaesth. 2011;55(2):111–5.

Gomes CA, Sartelli M, Saverio SD, Ansaloni L, Catena F, Coccolini F, et al. Acute appendicitis: proposal of a new comprehensive grading system based on clinical, imaging and laparoscopic findings. World J Emerg Surg WJES. 2015;10(1):60.

Watson J, Whiting PF, Brush JE. Interpreting a covid-19 test result. BMJ. 2020;369:m1808.

Gao Y, Xi H, Chen L. Emergency surgery in suspected COVID-19 patients with acute abdomen: case series and perspectives. Ann Surg. 2020;272(1):e38–9.

The COVID: HAREM (Had Appendicitis, Resolved/Recurred Emergency Morbidity/Mortality) Collaborators Group. The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study. Tech Coloproctol. 2020;25:1–11.

The CODA Collaborative. A randomized trial comparing antibiotics with appendectomy for appendicitis. New Engl J Med. 2020;383:1907–19.

COVIDSurg Collaborative. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. Lancet. 2020;396:27–38.

RIFT Study Group On behalf of the West Midlands Research Collaborative. Right Iliac Fossa Pain Treatment (RIFT) Study: protocol for an international, multicentre, prospective observational study. BMJ Open. 2018;8(1):e017574. https://doi.org/10.1136/bmjopen-2017-017574.

Kim K, Kim YH, Kim SY, Kim S, Lee YJ, Kim KP, et al. Low-dose abdominal CT for evaluating suspected appendicitis. New Engl J Med. 2012;366(17):1596–605.

Mariadason JG, Wang WN, Wallack MK, Belmonte A, Matari H. Negative appendicectomy rate as a quality metric in the management of appendicitis: impact of computed tomography, Alvarado score and the definition of negative appendicectomy. Ann Roy Coll Surg. 2012;94(6):395–401.

Gahide G, Frandon J, Vendrell J-F. COVID-19 patients presenting with afebrile acute abdominal pain. Clin Med. 2020;20(3):e4-6.

Sabbagh C, Masseline L, Grelpois G, Ntouba A, Dembinski J, Regimbeau J-M. Management of uncomplicated acute appendicitis as day case surgery: can outcomes of a prospective study be reproduced in real life? J Am Coll Surgeons. 2019;229(3):277–85.

Government of the United Kingdom. Foreign travel advice [Internet]. https://www.gov.uk/foreign-travel-advice. Accessed 27 Nov 2020

Xu S, Li Y. Beware of the second wave of COVID-19. Lancet. 2020;395(10233):1321–2.