Apolipoprotein L1, income and early kidney damage

BMC Nephrology - Tập 16 - Trang 1-8 - 2015
Ruth Tamrat1, Carmen A Peralta2,3, Salman M Tajuddin4, Michele K Evans4, Alan B Zonderman4, Deidra C Crews1,5,6,7
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
2Department of Medicine, University of California, San Francisco, USA
3San Francisco VA Medical Center, San Francisco, USA
4Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, Baltimore, USA
5Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, USA
6Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, USA
7Division of Nephrology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, USA

Tóm tắt

The degree to which genetic or environmental factors are associated with early kidney damage among African Americans (AAs) is unknown. Among 462 AAs in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, we examined the cross-sectional association between apolipoprotein L1 (APOL1) risk variants and income with: 1) mildly reduced eGFR (<75 mL/min/1.73 m2, creatinine-cystatin C equation) and 2) elevated urine albumin-to-creatinine ratio (ACR) (≥17 in men and ≥25 mg/g in women). High risk APOL1 status was defined by 2 copies of high-risk variants; low risk if 0 or 1 copy. Income groups were dichotomized as < $14,000/year (lowest income group) or ≥ $14,000/year. Logistic regression models were adjusted for age, sex, and % European ancestry. Overall, participants’ mean age was 47 years and 16% (n = 73) had high risk APOL1 status. Mean eGFR was 99 mL/min/1.73 m2. Mildly reduced eGFR was prevalent among 11% (n = 51). The lowest income group had higher adjusted odds (aOR) of mildly reduced eGFR than the higher income group (aOR 1.8, 95% CI 1.2-2.7). High-risk APOL1 was not significantly associated with reduced eGFR (aOR 1.5, 95% CI 0.9-2.5). Among 301 participants with ACR data, 7% (n = 21) had elevated ACR. Compared to low-risk, persons with high-risk APOL1 had higher odds of elevated ACR (aOR 3.8, 95% CI 2.0-7.3). Income was not significantly associated with elevated ACR (aOR 1.8, 95% CI 0.7-4.5). There were no significant interactions between APOL1 and income. Both genetic and socioeconomic factors may be important determinants of early kidney damage among AAs.

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BMC Nephrology

Tập 16

1-8

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