Antitumor Agents Based on Metal–Organic Frameworks

Angewandte Chemie - Tập 133 Số 31 - Trang 16901-16914 - 2021
Peng Gao1,2, Yuanyuan Chen1,2, Wei Pan1, Na Li1, Zhuang Liu3, Bo Tang1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014 P. R. China
2these authors contributed equally to this work
3Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Lab Carbon Based Functional Materials and Devices, Soochow University, Suzhou, 215123 Jiangsu, China

Tóm tắt

AbstractMetal–organic frameworks (MOFs) hold great promise for biomedical applications owing to their unique properties. The porous structures make MOFs excellent candidates for the delivery of different drugs; the flexibility in choosing metal ions and organic ligands makes it feasible to prepare MOFs with intrinsic antitumor activities and further devise MOF–drug synergistic systems; many other types of antitumor agents could also be developed using MOFs as the precursors/templates. Thus, the past two decades have witnessed the great development of MOF‐based drugs, especially in the antitumor field. This Minireview mainly focuses on the design and applications of MOF‐based antitumor agents. Four aspects covering the whole field are introduced: MOFs as carriers, MOFs as antitumor agents, MOF–drug synergistic systems, and MOF‐derived antitumor agents. The challenges and opportunities of MOFs for clinical antitumor applications are also discussed.

Từ khóa


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Angewandte Chemie

Tập 133 Số 31

16901-16914

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