Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models

Journal of Natural Medicines - Tập 61 - Trang 443-448 - 2007
Z. A. Zakaria1, N. A. Mohd Nor Hazalin2, S. N. H. Mohd Zaid2, M. Abdul Ghani2, M. H. Hassan2, H. K. Gopalan2, M. R. Sulaiman3
1Faculty of Pharmacy, Universiti Teknologi Mara, Shah Alam, Malaysia
2Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Shah Alam, Malaysia
3Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, UPM Serdang, Malaysia

Tóm tắt

The present study was carried out to elucidate the potential of aqueous extract of Muntingia calabura leaves aqueous extract (MCAE) as antinociceptive, anti-inflammatory and antipyretic agents using the formalin-, carrageenan-induced paw edema- and brewer’s yeast-induced pyrexia tests in rats. The extract was prepared by soaking the dried powdered leaves of M. calabura in distilled water (dH2O) overnight. The supernatant obtained, considered as a stock solution (100% concentration/strength), was then diluted to concentrations of 10% and 50% and used together in all experimental models. The MCAE, at concentrations of 10%, 50% and 100%, were found to show significant antinociceptive, anti-inflammatory and antipyretic activities in all tests. However, all of the activities occurred in a concentration-independent manner. The 50% and 100% concentrations of MCAE produced insignificant antinociceptive and antipyretic activities, respectively. Although the 100% concentration of MCAE produced significant (P<0.05) anti-inflammatory activity, the activity was lower than that of the 10% and 50% concentrations of MCAE. Based on the results, we conclude that the M. calabura leaves possessed antinociceptive, anti-inflammatory and antipyretic activities and, thus, justifies the Peruvian folklore claims of its medicinal values.

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Journal of Natural Medicines

Tập 61

443-448

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