Antidepressant-like effects of methanol extract of Hibiscus tiliaceus flowers in mice
Tóm tắt
Hibiscus tiliaceus L. (Malvaceae) is used in postpartum disorders. Our purpose was to examine the antidepressant, anxiolytic and sedative actions of the methanol extract of H. tiliaceus flowers using animal models. Adult male Swiss albino mice were treated with saline, standard drugs or methanol extract of H. tiliaceus and then subjected to behavioral tests. The forced swimming and tail suspension tests were used as predictive animal models of antidepressant activity, where the time of immobility was considered. The animals were submitted to the elevated plus-maze and ketamine-induced sleeping time to assess anxiolytic and sedative activities, respectively. Methanol extract of H. tiliaceus significantly decreased the duration of immobility in both animal models of antidepressant activity, forced swimming and tail suspension tests. This extract did not potentiate the effect of ketamine-induced hypnosis, as determined by the time to onset and duration of sleeping time. Our results indicate an antidepressant-like profile of action for the extract of Hibiscus tiliaceus without sedative side effect.
Tài liệu tham khảo
Brondegaard VJ: Contraceptive plant drugs. Plant Med. 1973, 23: 167-172. 10.1055/s-0028-1099428.
Holdworth D, Wamoi B: Medicinal plants of the Admiralty Island, Papua New Guinea. Part Int J Crude Drug Res. 1982, 20: 169-181.
Singh YH, Ikahihifo T, Panuve M, Slatter C: Folk medicine in Tonga: a study on the use of herbal medicines for obstetric and gynecological conditions and disorders. J Ethnopharmacol. 1984, 12: 305-329. 10.1016/0378-8741(84)90060-6.
Whistler WA: Traditional and herbal medicine in the Cook Islands. J Ethnopharmacol. 1985, 13: 239-280. 10.1016/0378-8741(85)90072-8.
Kobayashi J: Early Hawaiian uses of medicinal plants in pregnancy and childbirth. J Trop Pediatr Environ Child Health. 1976, 22: 260-262.
Holdsworth D: Traditional medicinal plants of Rarotonga, Cook Island. Part II. Pharm Biol. 1991, 29: 71-79. 10.3109/13880209109082853.
Holser RA, Bost G, Boven M: Phytosterol composition of hybridHibiscusseed oils. J Agric Food Chem. 2004, 52: 2546-2548. 10.1021/jf035473e.
Wang CJ, Wang JM, Lin WL, Chu CY, Chou FP, Tseng TH: Protective effect of Hibiscus anthocyanins against tert-butyl Hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol. 2000, 38: 411-416. 10.1016/S0278-6915(00)00011-9.
Farayi MH, Tarkhami AH: The effect of sour tea (H. sabdariffa) on essential hypertension. J Etnopharmacol. 1999, 65: 231-236. 10.1016/S0378-8741(98)00157-3.
Rosa RM, Melecchi da Costa MI, Halmenschlager R, Abad FC, Simoni CR, Caramão EB, Henriques JAP, de Paula Ramos ALL: Antioxidant and antimutagenic properties ofHibiscus tiliaceusL. methanolic extract. J Agric Food Chem. 2006, 54: 7324-7330. 10.1021/jf061407b.
Rosa RM, Moura DJ, Melecchi MI, dos Santos RS, Richter MF, Camarão EB, Henriques JA, de Paula Ramos ALL, Saffi J: Protective effects ofHibiscus tiliaceusL. methanolic extract to V79 cells against cytotoxicity and genotoxicity induced by hydrogen peroxide and tert-butyl-hydroperoxide. Toxicol In Vitro. 2007, 21: 1442-1452. 10.1016/j.tiv.2007.06.004.
Kumar R, Robson K: A prospective study of emotional disorders in childbearing women. Br J Psychiatry. 1984, 144: 35-47. 10.1192/bjp.144.1.35.
Nonacs R, Cohen L: Postpartum mood disorders: diagnosis and treatment guidelines. J Clin Psychiatry. 1998, 59: 34-40.
Beck CT: The effects of postpartum depression on child development: a meta-analysis. Arch Psychiatr Nurs. 1998, 12: 12-20. 10.1016/S0883-9417(98)80004-6.
Matthey S, Barnett B, Howie P: Diagnosing postpartum depression in mothers and fathers: whatever happened to anxiety?. J Affec Disord. 2003, 74: 139-147. 10.1016/S0165-0327(02)00012-5.
Hertzberg T, Wahlbeck K: The impact of pregnancy and puerperium on panic disorder: a review. J Psychosom Obstet Gynecol. 1999, 20: 59-64. 10.3109/01674829909075578.
Yun BS, Lee IK, Ryoo IJ, Yoo ID: Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans fromHibiscus syriacus. J Natl Prod. 2001, 64: 1238-1240. 10.1021/np0100946.
Melecchi MIS, Martinez MM, Abad FC, Zini PP, Nascimento Filho I, Caramão EB: Chemical Composition ofH. tiliaceusL. flowers: A study of extraction methods. J Sep Sci. 2002, 25: 86-90. 10.1002/1615-9314(20020101)25:1/2<86::AID-JSSC86>3.0.CO;2-7.
Porsolt RD, Bertin A, Jalfre M: Behavioural despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 1977, 229: 327-336.
Steru L, Chermat R, Thierry B, Simon P: The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacol. 1985, 85: 367-370. 10.1007/BF00428203.
File SE, Pellow S: The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress. Pharmacol Biochem Behav. 1985, 23: 737-741. 10.1016/0091-3057(85)90064-4.
Lister RG: Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav. 1987, 24: 525-529.
Mimura M, Namiki A, Kishi R, Ikeda T, Miyake H: Antagonistic effect of physostigmine on ketamine-induced anesthesia. Psychopharmacol. 1990, 102: 399-403. 10.1007/BF02244110.
Rabbani M, Sajjadi SE, Zarei HR: Anxiolytic effects ofStachys lavandulifoliaVahl on the elevated plus-maze model of anxiety in mice. J Ethnopharmacol. 2003, 89: 271-276. 10.1016/j.jep.2003.09.008.
Bourin M: Is it possible to predict the activity of a new antidepressant in animals with simple psychopharmacological tests?. Fundam Clin Pharmacol. 1990, 4: 49-64. 10.1111/j.1472-8206.1990.tb01016.x.
Drapier D, Bentué-Ferrer D, Laviolle B, Millet B, Allain H, Bourin M, Reymann JM: Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze. Behav Brain Res. 2007, 176: 202-209. 10.1016/j.bbr.2006.10.002.
Kõks S, Beljajev S, Koovit I, Abramov U, Bourin M, Vasar E: 8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze. Psychopharmacol. 2001, 153: 365-372. 10.1007/s002130000594.
Holmes A, Rodgers RJ: Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine. Eur J Pharmacol. 2003, 459: 221-230. 10.1016/S0014-2999(02)02874-1.
Galea LA, Wide JK, Barr AM: Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression. Behav Brain Res. 2001, 122: 1-9. 10.1016/S0166-4328(01)00170-X.
Rupprecht R: The neuropsychopharmacological potential of neuroactive steroids. J Psychiatric Res. 1997, 31: 297-314. 10.1016/S0022-3956(96)00060-X.
Reddy DS, Kulkarni SK: The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice. Psychopharmacol. 1998, 137: 391-400. 10.1007/s002130050635.
Urani A, Roman FJ, Phan VL, Su TP, Maurice T: The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test. J Pharmacol Exp Ther. 2001, 298: 1269-1279.
Dennerstein L, Burrows GD, Wood C, Hyman G: Hormones and sexuality: effect of estrogen and progestogen. Obstet Gynecol. 1980, 56: 316-322.
Magill PJ: Investigation of the efficacy of progesterone pessaries in the relief of symptoms of premenstrual syndrome. Progesterone Study Group. Br J Gen Pract. 1995, 45: 589-593.
Baker ER, Best RG, Manfredi RL, Demers LM, Wolf GC: Efficacy of progesterone vaginal suppositories in alleviation of nervous symptoms in patients with premenstrual syndrome. J Assist Reprod Genet. 1995, 12: 205-209. 10.1007/BF02211800.
Romeo E, Ströhle A, Spalletta G, di Michele F, Hermann B, Holsboer F, Pasini A, Rupprecht R: Effects of antidepressant treatment on neuroactive steroids in major depression. Am J Psychiatry. 1998, 15: 910-913.
Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunova DP, Costa E, Guidotti A: Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci. 1998, 95: 3239-3244. 10.1073/pnas.95.6.3239.
Lambert JJ, Belelli D, Hill-Venning C, Peters JA: Neurosteroids and GABAA receptor function. Trends Pharmacol Sci. 1995, 16: 295-303. 10.1016/S0165-6147(00)89058-6.
Rupprecht R, Zwanzger P: Significance of GABAA receptors for the pathophysiology and therapy of panic disorders. Nervenarzt. 2003, 74: 543-551. 10.1007/s00115-002-1433-x.
Serra M, Pisul MG, Dazzi L, Purdy RH, Biggio G: Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine. J Psychopharmacol. 2002, 16: 133-138. 10.1177/026988110201600203.
Nechmad A, Maayan R, Spivak B, Ramadan E, Poyurovsky M, Weizman A: Brain neurosteroid changes after paroxetine administration in mice. Eur Neuropsychopharmacol. 2003, 13: 327-332. 10.1016/S0924-977X(03)00015-4.
Reddy DS, Kulkarni SK: Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice. Methods Find Exp Clin Pharmacol. 1997, 19: 665-681.
Rodgers RJ, Johnson NJ: Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice. Pharmacol Biochem Behav. 1998, 59: 221-232. 10.1016/S0091-3057(97)00339-0.
Bilici M, Efe H, Köroglu MA, Uydu HA, Bekaroglu M, Deger O: Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affec Disord. 2001, 64: 43-51. 10.1016/S0165-0327(00)00199-3.
Abdalla DS, Bechara EJ: The effect of chlorpromazine and Li2CO3 on the superoxide dismutase and glutathione peroxidase activities of rat brain, liver and erythrocytes. Biochem Mol Biol Int. 1994, 34: 1085-1090.
Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R: Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Rep. 2003, 8: 365-370. 10.1179/135100003225003393.
Sairam K, Dorababu M, Goel RK, Bhattacharya SK: Antidepressant activity of standardized extract ofBacopa monnierain experimental models of depression in rats. Phytomedicine. 2002, 9: 207-211. 10.1078/0944-7113-00116.
Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S: Antioxidant activity ofBacopa monnierain rat frontal cortex, striatum and hippocampus. Phytother Res. 2000, 14: 174-179. 10.1002/(SICI)1099-1573(200005)14:3<174::AID-PTR624>3.0.CO;2-O.
Singh GK, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S: Antidepressant activity ofAsparagus racemosusin rodent models. Pharmacol Biochem Behav. 2009, 91: 283-290. 10.1016/j.pbb.2008.07.010.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/12/41/prepub