Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test

Piotr Brański1, Agnieszka Palucha1, Bernadeta Szewczyk1, Joanna M. Wierońska1, Andrzej Pilc2,1, Gabriel Nowak1,3
1Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
2Institute of Public Health, Collegium Medicum, Jagiellonian University, Krakow, Poland
3Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland

Tóm tắt

The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.

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