Tăng cường phụ thuộc vào kháng thể trong bệnh nhiễm virus ếch 3
Tóm tắt
Các virus thuộc họ
Chúng tôi đã chỉ ra rằng huyết thanh chống FV3 có mặt tại thời điểm nhiễm FV3 làm tăng khả năng gây nhiễm của virus trong hai dòng tế bào cá không miễn dịch. Chúng tôi nhận thấy rằng việc tăng cường phụ thuộc vào kháng thể của FV3 phụ thuộc vào phần Fc của các kháng thể chống FV3 nhưng không liên quan đến bổ thể. Hơn nữa, sự hiện diện của huyết thanh chống FV3 trong quá trình nhiễm FV3 ở một dòng tế bào động vật có vú không miễn dịch dẫn đến việc trung hòa virus. Các kết quả của chúng tôi gợi ý rằng một thụ thể bề mặt tế bào đặc hiệu cho các dòng tế bào cá là nguyên nhân gây tăng cường này.
Báo cáo này đại diện cho bằng chứng đầu tiên về việc tăng cường phụ thuộc vào kháng thể trong các virus iridovirus. Dữ liệu cho thấy huyết thanh chống FV3 có thể vừa trung hòa vừa tăng cường nhiễm virus và việc tăng cường này liên quan đến một con đường tăng cường phụ thuộc vào kháng thể mới được tìm thấy ở cá có vây mà phụ thuộc vào Fc.
Từ khóa
Tài liệu tham khảo
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