Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori

Microbiology and Immunology - Tập 48 Số 4 - Trang 251-261 - 2004
Keiji Funatogawa1, Shunji Hayashi1, Hirofumi Shimomura1, Takashi Yoshida2, Tsutomu Hatano2, Hideyuki Ito2, Yoshikazu Hirai1
1Division of Bacteriology, Department of Infection and Immunity Jichi Medical School Tochigi 329-0498 Japan
2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences Okayama University Okayama Okayama 700-8530 Japan

Tóm tắt

Abstract

Helicobacter pylori is a major etiological agent in gastroduodenal disorders. In this study, we isolated 36 polyphenols and 4 terpenoids from medicinal plants, and investigated their antibacterial activity against H. pylori in vitro. All hydrolyzable tannins tested demonstrated promising antibacterial activity against H. pylori. Monomeric hydrolyzable tannins revealed especially strong activity. Other compounds demonstrated minimal antibacterial activity with a few exceptions. A monomeric hydrolyzable tannin, Tellimagrandin I demonstrated time‐ and dose‐dependent bactericidal activity against H. pylori in vitro. On the other hand, hydrolyzable tannins did not affect the viability of MKN‐28 cells derived from human gastric epithelium. Hydrolyzable tannins, therefore, have potential as new and safe therapeutic regimens against H. pylori infection. Furthermore, we investigated effects of hydrolyzable tannins on lipid bilayer membranes. All the hydrolyzable tannins tested demonstrated dose‐dependent membrane‐damaging activity. However, it remains to be elucidated whether their membrane‐damaging activity directly contributes to their antibacterial action.

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Thông tin xuất bản

Microbiology and Immunology

Tập 48 Số 4

251-261

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