Antonio Ceriello1, Dario Giugliano1, Pierre J. Lefèbvre2
1Cattedra di Diabetologia e Dietoterapia I Facoltà di Medicina, Università di Napoli, Napoli, Italia
2Département de Medecine, Service de Diabétologie, Nutrition et Maladies Métaboliques, Centre Hospitalier Universitaire de Liége, Liége, Belgique
Tóm tắt
1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported.2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect at a dose of 12 mmol.3. These data suggest that anti-oxidants might have a dilatatory effect and that an imbalance of the nitric oxide-free radical interaction might facilitate the development of hypertension in humans.
