Anti-aging trait of whey protein against brain damage of senile rats

Chu W, Wang P, Ma Z, Peng L, Wang Z, Chen Z (2022) Ultrasonic treatment of Dendrobium officinale polysaccharide enhances antioxidant and anti-inflammatory activity in a mouse D-galactose-induced aging model. Food Sci Nutr 00:1–11. https://doi.org/10.1002/fsn3.2867 Kalaria RN, Hase Y (2019) Neurovascular ageing and age-related diseases. Subcell Biochem 91:477–499 Lin B, Xu D, Wu S, Qi S, Xu Y, Liu X, Zhang X, Chen C (2021) Antioxidant effects of Sophora davidi (Franch.) Skeels on d–galactose–induced aging model in mice via activating the SIRT1/p53 pathway. Front Pharmacol 12:754554. https://doi.org/10.3389/fphar.2021.754554 Wan S, Liu Y, Shi J, Fan D, Li B (2021) Anti-photoaging and anti-inflammatory effects of ginsenoside Rk3 during exposure to UV irradiation. Front Pharmacol 12:716248. https://doi.org/10.3389/fphar.2021.716248 Fulop GA, Tarantini S, Yabluchanskiy A, Molnar A, Prodan CI, Kiss T et al (2019) Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment. Am J Physiol Heart Circ Physiol 6(5):H1124–H1140 Metzler-Baddeley C, Mole JP, Sims R, Fasano F, Evans J, Jones DK et al (2019) Fornix white matter glia damage causes gray matter damage during age-dependent limbic decline. Sci Rep 9(1):1060 Thammisetty SS, Pedragosa J, Weng YC, Calon F, Planas A, Kriz J (2018) Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage. J Neuroinflammation 15(1):312 Sessa F, Maglietta F, Bertozzi G, Salerno M, Di Mizio G, Messina G et al (2019) Human brain injury and miRNAs: an experimental study. Int J Mol Sci 20(7):1546 Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20(3):148–160 Schipper HM, Song W, Tavitian A, Cressatti M (2019) The sinister face of heme oxygenase-1 in brain aging and disease. Prog Neurobiol 172:40–70 Saccà SC, Cutolo Rossi T (2019) Visual defects and ageing. Subcell Biochem 91:393–434 Afkhami M, Kermanshahi H, Majidzadeh Heravi R (2020) Evaluation of whey protein sources on performance, liver antioxidants and immune responses of broiler chickens challenged with ethanol. J Anim Physiol Anim Nutr 104(3):898–908. https://doi.org/10.1111/jpn.13327 Mignone LE, Wu T, Horowitz M, Rayner CK (2015) Whey protein: the “whey” forward for treatment of type 2 diabetes? World J Diabetes 6(14):1274–1284 Rodrigues G, Moraes T, Elisei L, Malta I, dos Santos R, Novaes R, Lollo P, Galdino G (2021) Resistance exercise and whey protein supplementation reduce mechanical allodynia and spinal microglia activation after acute muscle trauma in rats. Front Pharmacol 12:726423. https://doi.org/10.3389/fphar.2021.726423 Toffolon A, Rocco-Ponce M, Vettore M, Iori E, Lante A, Tessari P (2021) Effect of reversal of whey-protein to casein ratio of cow milk, on insulin, incretin and amino acid responses in humans. Mol Nutr Food Res. https://doi.org/10.1002/mnfr.202100069 Kirk B, Mooney K, Vogrin S, Jackson M, Duque G, Khaiyat O, Amirabdollahian F (2021) Leucine-enriched whey protein supplementation, resistance-based exercise, and cardiometabolic health in older adults: a randomized controlled trial. J Cachexia Sarcopenia Muscle. https://doi.org/10.1002/jcsm.12805 Waworuntu RV, Hanania T, Boikess SR, Rex CS, Berg BM (2016) Early life diet containing prebiotics and bioactive whey protein fractions increased dendritic spine density of rat hippocampal neurons. Int J Dev Neurosci 55:28–33 Krissansen GW (2007) Emerging health properties of whey proteins and their clinical implications. J Am Coll Nutr 26:713S-723S Warinner C, Hendy J, Speller C, Cappellini E, Fischer R, Trachsel C et al (2014) Direct evidence of milk consumption from ancient human dental calculus. Sci Rep 4:7104 Gu F, Chauhan V, Chauhan A (2015) Glutathione redox imbalance in brain disorders. Curr Opin Clin Nutr Metab Care 18(1):89–95 Kerasioti E, Stagos D, Tsatsakis AM, Spandidos DA, Taitzoglou I, Kouretas D (2018) Effects of sheep/goat whey protein dietary supplementation on the redox status of rats. Mol Med Rep 17(4):5774–5781 Andreoli MF, Stoker C, Lazzarino GP, Canesini G, Luque EH, Ramos JG et al (2016) Dietary whey reduces energy intake and alters hypothalamic gene expression in obese phyto-oestrogen-deprived male rats. Brit J Nutr 116(6):1125–1133 Shertzer HG, Krishan M, Genter MB (2013) Dietary whey protein stimulates mitochondrial and decreases oxidative stress in mouse female brain. Neurosci Lett 548:159–164 Ajarem J, Allam AA, Ebaid H, Maodaa SN, Al-Sobeai SM, Rady AM et al (2013) Neurochemical, structural and neurobehavioral evidence of neuronal protection by whey proteins in diabetic albino mice. Behav Brain Function 11:7 Ho ST, Hsieh YT, Wang SY, Chen MJ (2019) Improving effect of a probiotic mixture on memory and learning abilities in d-galactose-treated aging mice. J Dairy Sci 102(3):1901–1909 Ano Y, Kutsukake T, Sasaki T, Uchida S, Yamada K, Kondo K (2019) Identification of a novel peptide from β-casein that enhances spatial and object recognition memory in mice. J Agri Food Chem 67(29):8160–8167 Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L et al (2018) The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact. Free Rad Biol Med 24:328–341 Tosukhowong P, Boonla C, Dissayabutra T, Kaewwilai L, Muensri S, Chotipanich C et al (2016) Biochemical and clinical effects of whey protein supplementation in Parkinson’s disease: A pilot study. J Neurol Sci 2(367):162–170 Rondanelli M, Klersy C, Terracol G, Talluri J, Maugeri R, Guido D et al (2016) Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly. Am J Clin Nutr 103(3):830–840 Parris S, Baginskla MA (1991) Rapid method for the determination of whey protein denaturation. J Dairy Sci 74:58–64 Essig AM, Kleyn DH (1983) Determination of lactose in milk: comparison of methods. J Assoc Off Anal Chem 66(6):1514–1516 Lim YY, Quah EPL (2007) Antioxidant properties of different cultivars of Portulaca Oleracea. Food Chem 103(3):734–740 Karami S, Roayaei M, Hamzavi H, Bahmani M, Hassanzad-Azar H, Leila M et al (2017) Isolation and identification of probiotic Lactobacillus from local dairy and evaluating their antagonistic effect on pathogens. Int J Pharm Invest 7(3):137–141 Al-Gebaly AS (2019) Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats. Saudi J Biol Sci 26(5):950–956. https://doi.org/10.1016/j.sjbs.2018.03.014 Al-Gebaly AS (2019) Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats. Saudi J Biol Sci 26:950–956. https://doi.org/10.1016/j.sjbs.2018.03.014 Fairbanks V, Klee G (1996) Biochemistry aspects of haematology. Tietz fundamental of clinical chemistry 4th edn. WB Saunders Co., Philadelphia, 704, 30 Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351–358 Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E (2005) Resting metabolic rate and respiratory quotient in human longevity. J Clin Endocrinol Metab 90:409–413 Solomon TP, Sistrun SN, Krishnan RK, Del Aguila LF, Marchetti CM, O’Carroll SM et al (2008) Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol (1985) 104(5):1313–1319 Jura M, Kozak LP (2016) Obesity and related consequences to ageing. Age (Dordr) 38(1):23 Garg G, Singh S, Singh AK, Rizvi SI (2018) Whey protein concentrate supplementation protects rat brain against aging-induced oxidative stress and neurodegeneration. Appl Physiol Nutr Metabol 43(5):437–444 Gholamian-Dehkordi N, Luther T, Asadi-Samani M, Mahmoudian MR (2017) An overview on natural antioxidants for oxidative stress reduction in cancers; a systematic review. Immunopathol Persa 3(2):e12 Li X, Chen Y, Shao S, Tang Q, Chen W, Chen Y et al (2016) Oxidative stress induces the decline of brain EPO expression in aging rats. Exp Gerontol 83:89–93 Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine, second reprint. Clarendon Press, Oxford, p 543 Sousa MSB, Holanda IMS, Monteiro HMC, Amâncio-Dos-Santos  (2018) Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex. Acta Cir Bras 6:472 Amin AH, Bughdadi FA, Abo-Zaid MA, Ismail AH, El-Agamy SA, Alqahtani A et al (2019) Immunomodulatory effect of papaya (Carica papaya) pulp and seed extracts as a potential natural treatment for bacterial stress. J Food Biochem 43(12):e13050 Stefanatos R, Sanz A (2018) The role of mitochondrial ROS in the aging brain. FEBS Lett 592(5):743–758 Parodi PW (2007) A role for milk proteins and their peptides in cancer prevention. Curr Pharm Design 13(8):813–828 Lazarov O, Hollands C (2018) Hippocampal neurogenesis: learning to remember. Prog Neurobiol 138–140:1–18 Hashemilar M, Khalili M, Rezaeimanesh N, Sadeghi Hokmabadi E, Rasulzade S, Shamshirgaran SM et al (2020) Effect of whey protein supplementation on inflammatory and antioxidant markers, and clinical prognosis in acute ischemic stroke (TNS Trial): A randomized, double blind, controlled, clinical trial. Adv Pharm Bull 10(1):135–140 Banerjee S, Poddar MK (2016) Aging-induced changes in brain regional serotonin receptor binding: effect of arnosine. Neuroscience 319:79–91 Ferrari F, Viscardi P, Gorini A, Villa RF (2019) Synaptic ATPases system of rat frontal cerebral cortex during aging. Neurosci Lett 694:74–79 Kim WS, Bhatia S, Elliott DA, Agholme L, Kågedal K, McCann H et al (2010) Increased ATP-binding cassette transporter A1 expression in Alzheimer’s disease hippocampal neurons. J Alzheimers Dis 21(1):193–205 Hefti MM, Kim S, Bell AJ, Betters RK, Fiock KL, Iida MA, Smalley ME et al (2019) Tau Phosphorylation and aggregation in the developing human brain. J Neuropathol Exp Neurol 78(10):930–938 Shen LL, Li WW, Xu YL, Gao SH, Xu MY, Bu XL, Liu YH et al (2019) Neurotrophin receptor p75 mediates amyloid β-induced tau pathology. Neurobiol Dis 132:104567 Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE et al (2014) Alzheimer’s disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci 34(41):13629–13643 Hara Y, Rapp PR, Morrison JH (2012) Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age 34(5):1051–1073 Byman E, Schultz N (2018) Netherlands Brain Bank, Fex M, Wennström M, Brain alpha-amylase: a noval energy regulator important in Alzheimer disease? Brain Pathol 28(6):920–932 Brown AM, Ransom BR (2007) Astrocyte glycogen and brain energy metabolism. Glia 55(12):1263–1271 Jan Y, Malik M, Sharma V, Yaseen M, Bora J, Haq A (2021) Utilization of whey for formulation of whey jamun juice ice pops with antidiabetic potential. Food Frontiers. https://doi.org/10.1002/fft2.90 García-Ayllón MS, Riba-Llena I, Serra-Basante C, Alom J, Boopathy R, Sáez-Valero J (2010) Altered levels of acetylcholinesterase in Alzheimer plasma. PLoS ONE 5(1):e8701 Battelli MG, Polito L, Bortolotti M, Bolognesi A (2016) Xanthine oxidoreductase-derived reactive species: physiological and pathological effects. Oxid Med Cell Long 2016:3527579 Harrison R (2002) Structure and function of xanthine oxido-reductase: where are we now? Free Rad Biol Med 33(6):774–797 Bürklen TS, Schlattner U, Homayouni R, Gough K, Rak M, Szeghalmi A, Wallimann T (2008) The creatine kinase/creatine connection to Alzheimer’s disease: CK-inactivation, APP-CK complexes and focal creatine deposits. J Biomed Biotechnol 3:35936 Budni J, Bellettini-Santos T, Mina F, Garcez ML, Zugno AI (2015) The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease. Aging Dis 6(5):331–341 Mahinrad S, Bulk M, van der Velpen I, Mahfouz A, van Roon-Mom W, Fedarko N et al (2018) Natriuretic peptides in post-mortem brain tissue and cerebrospinal fluid of non-demented humans and Alzheimer’s disease patients. Front Neurosci 12:864 Ochoa TJ, Sizonenko SV (2017) Lactoferrin and prematurity: a promising milk protein? Biochem Cell Biol 95(1):22–30 Qian Y, Zhang J, Zhou X, Yi R, Mu J, Long X et al (2018) Lactobacillus plantarum CQPC11 Isolated from sichuan pickled cabbages antagonizes d-galactose-induced oxidation and aging in mice. Molecules 23(11):3026 Ano Y, Ayabe T, Kutsukake T, Ohya R, Takaichi Y, Uchida S et al (2018) Novel lactopeptides in fermented dairy products improve memory function and cognitive decline. Neurobiol Aging 72:23–31 Wurtman RJ, Cansev M, Sakamoto T, Ulus IH (2009) Use of phosphatide precursors to promote synaptogenesis. Ann Rev Nutr 29:59–87