Sự phân bổ của Annexin A1 và sự liên quan của nó đến ung thư

Clinical Science - Tập 130 Số 4 - Trang 205-220 - 2016
Zied Boudhraa1,2, Bernadette Bouchon1,2, Claire Viallard1,2, M. D’Incan1,2, Françoise Degoul1,2
1Clermont Université, Université d'Auvergne, Imagerie Moléculaire et Thérapie Vectorisée, BP 10448, F-63000 Clermont-Ferrand, France
2Inserm, U 990, F-63000 Clermont-Ferrand, France

Tóm tắt

Annexin A1 (ANXA1) là một protein liên kết phospholipid được điều chỉnh bởi Ca2+, có vai trò trong nhiều quá trình của tế bào. ANXA1 ban đầu được nghiên cứu rộng rãi trong việc giải quyết viêm, nhưng sau đó đã được báo cáo là biểu hiện quá mức trong một số lượng lớn các loại ung thư. Các nghiên cứu sâu hơn đã chỉ ra rằng protein này có thể có nhiều vai trò trong tiến triển ung thư và hoạt động ở nhiều mức độ khác nhau (từ khởi phát ung thư đến di căn). Điều này một phần liên quan đến vị trí của ANXA1 trong các khoang tế bào khác nhau. ANXA1 có thể hiện diện trong nhân tế bào, tế bào chất và/hoặc liên kết với màng. Vị trí cuối cùng cho phép ANXA1 bị cắt phân giải proteolytically và/hoặc có thể tiếp cận các đối tác nhận biết, đó là các thụ thể peptide formyl. Thực tế, trong một số loại ung thư, ANXA1 được tìm thấy trên bề mặt tế bào, nơi nó kích thích các thụ thể peptide formyl để khởi động các con đường oncogenic. Trong bài đánh giá hiện tại, chúng tôi xem xét các vị trí khác nhau của ANXA1 và sự liên kết của chúng với các con đường không điều hòa thường thấy trong ung thư. Chúng tôi đã cụ thể hóa các con đường không cổ điển của sự ngoại hóa ANXA1, ý nghĩa của việc cắt phân giải của nó và vai trò của phức hợp ANXA1–thụ thể peptide formyl trong sự tiến triển của ung thư.

Từ khóa


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