Animal models for studying the etiology and treatment of low back pain

Journal of Orthopaedic Research - Tập 36 Số 5 - Trang 1305-1312 - 2018
Changgui Shi1, Sujun Qiu2, Scott M. Riester3, Vaskar Das4, Bingqian Zhu5, Atiyayein A. Wallace4, André J. van Wijnen3, Fackson Mwale6, James C. Iatridis7, Daisuke Sakai8, Gina Votta‐Velis9,10, Wen Yuan1, Hee‐Jeong Im11,10
1Department of Orthopedic Surgery Changzheng Hospital Second Military Medical University of China Shanghai China
2Department of Orthopedic Surgery Zhujiang Hospital Southern Medical University Guangzhou China
3Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
4Department of Biochemistry, Rush University Medical Center, Chicago, Illinois
5Departments of Biobehavioral Health Science University of Illinois at Chicago (UIC) Chicago Illinois
6Department of Surgery McGill University and Orthopaedic Research Laboratory Lady Davis Institute for Medical Research SMBD‐Jewish General Hospital Montreal Canada
7Leni & Peter May Department of Orthopaedics Icahn School of Medicine at Mount Sinai New York New York
8Department of Orthopaedic Surgery, Tokai University School of Medicine, Kanagawa, Japan
9Department of Anesthesiology University of Illinois at Chicago (UIC) Chicago Illinois
10Jesse Brown Veterans Affairs Medical Center (JBVAMC) at Chicago Chicago Illinois
11Department of Bioengineering University of Illinois at Chicago (UIC) Chicago Illinois

Tóm tắt

ABSTRACT

Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle‐induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1305–1312, 2018.

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Journal of Orthopaedic Research

Tập 36 Số 5

1305-1312

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