Angiostatin induces and sustains dormancy of human primary tumors in mice

Folkman, J. What is the evidence that tumors are angiogenesis dependent?. J. Nati. Cancer Inst. 82, 4–6 (1989).

Hori, A. et al. Suppression of solid tumor growth by immunoneutraliaing monoclonal antibody against human basic fibroblast growth factor. Cancer Res. 51, 6180–6184 (1991).

Kim, K.J. et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362, 841–844 (1993).

Millauer, B., Shawver, L.K., Plate, K.H., Risau, W. & Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367, 576–579 (1994).

O'Reilly, M.S. et al. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315–328 (1994).

Holmgren, L., O'Reilly, M.S. & Folkman, J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med. 1, 149–153 (1995).

Key, G. et al. New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three base pair repetitive elements encoding for the Ki-67 epitope. Lab. Invest. 68, 629–636 (1993).

Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493–501 (1992).

Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 27–31 (1995).

Hamada, J., Cavanaugh, P.G., Lotan, O. & Nicolson, G.L. Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis. Br. J. Cancer 66, 349–354 (1992).

Nicosia, R.F., Tchao, R. & Leighton, J. Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture. Clin. Expl. Metastasis 4, 91–104 (1986).

Alon, T. et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1, 1024–1028 (1995).

Folkman, J. Tumor angiogenesis and tissue factor. Nature Med. 2, 167–168 (1996).

Teicher, B.A., Holden, S.A., Ara, G., Sotomayor, E.A. & Dong, H.Z. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int. J. Cancer 57, 1–6 (1994).

Folkman, J. The vascularization of tumors. Scientific American 234, 58–73 (1976).

Folkman, J. Clinical applications of angiogenesis research. New Engl. J. Medicine 333, 1757–1763 (1995).

Deutsch, D.G. & Mertz, E.T. Plasminogen: purification from human plasma by affinity chromatography. Science 170, 1095–1096 (1970).

Sottrup-Jensen, L., Claeys, H., Zajdel, M., Petersen, T.E. & Magnusson, S. The primary structure of human plasminogen: isolation of two lysine-binding fragments and one “mini-” plasminogen (MW 38,000) by elastase-catalyzed-specific limited proteolysis. in Progress in Chemical Fibrinolysis and Thrombolysis, vol. 3 (eds. Davidson, J.F., Rowan, R.M., Samama, M.M. & Desnoyers, P.C.) 191–209 (Raven Press, New York, 1978).

Kenyon, B.M. et al. A model of angiogenesis in the mouse cornea. Invest. Opthal. Vis. Sci. (in the press).