Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells
Tóm tắt
Từ khóa
Tài liệu tham khảo
Wichterle H, Przedborski S . What can pluripotent stem cells teach us about neurodegenerative diseases? Nat Neurosci 2010; 13: 800–804.
Chang CY, Hsuuw YD, Huang FJ, Shyr CR, Chang SY, Huang CK et al. Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells. Fertil Steril 2006; 85 (Suppl 1): 1195–1203.
Rosenberg KM, Sherman GF . Testosterone induced pup-killing behavior in the ovariectomized female rat. Physiol Behav 1974; 13: 697–699.
Mann MA, Svare B . Prenatal testosterone exposure elevates maternal aggression in mice. Physiol Behav 1983; 30: 503–507.
Fritz H, Giese K, Suter HP . Prenatal and postnatal development of rats following the maternal treatment with testosterone during the late period of embryogenesis. Arzneim Forsch 1984; 34: 780–782.
Yun YW, Yuen BH, Moon YS . Effects of an antiandrogen, flutamide, on oocyte quality and embryo development in rats superovulated with pregnant mare’s serum gonadotropin. Biol Reprod 1988; 39: 279–286.
Heinlein CA, Chang C . Androgen receptor (AR) coregulators: an overview. Endocr Rev 2002; 23: 175–200.
Kang Z, Janne OA, Palvimo JJ . Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Mol Endocrinol 2004; 18: 2633–2648.
Kang HY, Tsai MY, Chang C, Huang KE . Mechanisms and clinical relevance of androgens and androgen receptor actions. Chang Gung Med J 2003; 26: 388–402.
Thomas M, Yu Z, Dadgar N, Varambally S, Yu J, Chinnaiyan AM et al. The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor. J Biol Chem 2005; 280: 21264–21271.
Rao RV, Bredesen DE . Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 2004; 16: 653–662.
Luo S, Mao C, Lee B, Lee AS . GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol 2006; 26: 5688–5697.
Rubinsztein DC . The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 2006; 443: 780–786.
Bence NF, Sampat RM, Kopito RR . Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001; 292: 1552–1555.
Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F et al. CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. J Neurosci 2007; 27: 5115–5126.
Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR et al. Kennedy’s disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 1999; 72: 185–195.
Kobayashi Y, Miwa S, Merry DE, Kume A, Mei L, Doyu M et al. Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner. Biochem Biophys Res Commun 1998; 252: 145–150.
Kim I, Xu W, Reed JC . Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2008; 7: 1013–1030.
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 1998; 12: 982–995.
Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C . From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proc Natl Acad Sci USA 2001; 98: 3018–3023.
Shen J, Chen X, Hendershot L, Prywes R . ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 2002; 3: 99–111.
Kobayashi Y, Kume A, Li M, Doyu M, Hata M, Ohtsuka K et al. Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 2000; 275: 8772–8778.
Flynn GC, Pohl J, Flocco MT, Rothman JE . Peptide-binding specificity of the molecular chaperone BiP. Nature 1991; 353: 726–730.
Katsuno M, Adachi H, Inukai A, Sobue G . Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA). Cytogenet Genome Res 2003; 100: 243–251.
Morimoto RI . Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 2008; 22: 1427–1438.
Walcott JL, Merry DE . Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy. J Biol Chem 2002; 277: 50855–50859.
Bailey CK, Andriola IF, Kampinga HH, Merry DE . Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy. Hum Mol Genet 2002; 11: 515–523.
Oh SK, Kim HS, Ahn HJ, Seol HW, Kim YY, Park YB et al. Derivation and characterization of new human embryonic stem cell lines: SNUhES1, SNUhES2, and SNUhES3. Stem Cells 2005; 23: 211–219.
Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF et al. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/senseless proteins. Cell 2005; 122: 633–644.
Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, She WC, Luchak JM, Martinez P et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 2000; 408: 101–106.
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J et al. Alpha-synuclein locus triplication causes Parkinson’s disease. Science 2003; 302: 841.
Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 2001; 293: 711–714.
Huguenard AL, Fernando SM, Monks DA, Sengelaub DR . Overexpression of androgen receptors in target musculature confers androgen sensitivity to motoneuron dendrites. Endocrinology 2011; 152: 639–650.
Monks DA, Johansen JA, Mo K, Rao P, Eagleson B, Yu Z et al. Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. Proc Natl Acad Sci USA 2007; 104: 18259–18264.
Munro S, Pelham HR . An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell 1986; 46: 291–300.
Morris JA, Dorner AJ, Edwards CA, Hendershot LM, Kaufman RJ . Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins. J Biol Chem 1997; 272: 4327–4334.
Matsumoto A, Hanawalt PC . Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Cancer Res 2000; 60: 3921–3926.
Ni M, Lee AS . ER chaperones in mammalian development and human diseases. FEBS Lett 2007; 581: 3641–3651.
Waelter S, Boeddrich A, Lurz R, Scherzinger E, Lueder G, Lehrach H et al. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol Biol Cell 2001; 12: 1393–1407.
Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C et al. Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci 2003; 23: 2203–2211.
Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T . Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. Biochem J 2007; 402: 581–589.
Kudo T, Imaizumi K, Hara H . A molecular chaperone inducer as potential therapeutic agent for neurodegenerative disease. Nihon Shinkei Seishin Yakurigaku Zasshi 2007; 27: 63–67.
Bolte S, Cordelieres FP . A guided tour into subcellular colocalization analysis in light microscopy. J Microsc 2006; 224: 213–232.
Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B et al. IRE1 signaling affects cell fate during the unfolded protein response. Science 2007; 318: 944–949.
Wanker EE, Scherzinger E, Heiser V, Sittler A, Eickhoff H, Lehrach H . Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods Enzymol 1999; 309: 375–386.