Analytical characterization of three cathinone derivatives, 4‐MPD, 4F–PHP and bk‐EPDP, purchased as bulk powder from online vendors

Drug Testing and Analysis - Tập 10 Số 2 - Trang 372-378 - 2018
Orapan Apirakkan1, Anca Frinculescu2, Trevor Shine2, Mark C. Parkin1,3, Agostino Cilibrizzi4, Nunzianda Frascione1, Vincenzo Abbate3,4
1Analytical & Environmental Sciences Division King's College London London UK
2TICTAC Communications Ltd, Room 1.159 Jenner Wing, St George's University of London, London, UK
3Drug Control Centre King's College London, London, UK
4Institute of Pharmaceutical Science, King’s College London, London, UK

Tóm tắt

Novel emerging drugs of abuse, also referred as new psychoactive substances, constitute an ever‐changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One such class, synthetic cathinones, namely β‐keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them. By using complementary analytical techniques (i.e. one‐ and two‐dimensional NMR, FT‐IR, GC–MS, HRMS and HPLC‐UV), this study investigates the detection, identification and full characterization of 1‐(4‐methylphenyl)‐2‐(methylamino)pentanone (4‐methylpentedrone, 4‐MPD), 1‐(4‐fluorophenyl)‐2‐(pyrrolidin‐1‐yl)hexanone (4F–PHP) and 1‐(1,3‐benzodioxol‐5‐yl)‐2‐(ethylamino)‐1‐pentanone (bk‐EPDP), three emerging cathinone derivatives.

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Drug Testing and Analysis

Tập 10 Số 2

372-378

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