Analysis of Donor Safety in High Yield Plateletpheresis Procedures: An Experience from Tertiary Care Hospital in South India

Indian Journal of Hematology and Blood Transfusion - Tập 36 Số 3 - Trang 542-549 - 2020
Kumawat, Vijay1,2, Goyal, Manu3, Marimuthu, Palniappan4
1Department of Transfusion Medicine, Citizens Hospital, Hyderabad, India
2Transfusion Medicine & Haematology, NIMHANS, Bengaluru, India
3Department of Hematopathology and Genetics, AMPATH at Citizens Hospital, Hyderabad, India
4Department of Biostatistics, National Institute of Mental Health and NeuroSciences, Bengaluru, India

Tóm tắt

The apheresis platelets are the preferred blood components for the thrombocytopenic hemato-oncology patients. The one of the important factors for post transfusion increment is the dose of the platelet product infused. The minimum platelet product yield is defined but the amount of maximum possible platelets collection from a single donor is not universally defined. There is lots of apprehension in our country for apheresis procedures harvesting more than a standard unit. This retrospective observational study was conducted to determine safety of high yield plateletapheresis collection among Indian donors This retrospective observational study was conducted for a period of 15 months including all consecutive plateletapheresis procedures. The informed consent had been obtained from all donors including high yield plateletapheresis (Yield ≥ 5 × 1011). The apheresis product was subjected to platelet count. The donor adverse reactions were recorded along with procedural details. Post procedure complete blood count was done for the donors who consented for post procedure blood sample draw A total 569 procedures were performed during this period including 174 high yield procedure. The 526 procedures were analyzed for adverse donor reactions. The 43 were excluded for adverse donor reaction analysis due to yield less than 3 × 1011 (n = 43). The adverse reactions rate between high yield procedures (18/174, 10.34%) and normal yield (20/352, 5.68%) were not statistically different (p = 0.052). The phlebotomy related complication (3.23%) followed by citrate toxicity (2.28%) were the two most common adverse reaction observed. The adverse reactions associated with high yield plateletapheresis procedures are comparable to normal yield procedures in term of overall adverse reactions observed and post procedural platelet counts. This can be beneficial to patients by providing products of greater yield.

Tài liệu tham khảo

citation_journal_title=Transfusion; citation_title=Continued decline in blood collection and transfusion in the United States-2015; citation_author=KD Ellingson, MRP Sapiano, KA Haass, AA Savinkina, ML Baker, KW Chung; citation_volume=57; citation_issue=Suppl 2; citation_publication_date=2017; citation_pages=1588-1598; citation_id=CR1

citation_journal_title=Transfus Apher Sci.; citation_title=Platelet transfusions in clinical practice at a multidisciplinary hospital in North India; citation_author=A Verma, P Pandey, D Khetan, R Chaudhary; citation_volume=39; citation_issue=1; citation_publication_date=2008; citation_pages=29-35; citation_id=CR2

citation_journal_title=Asian J Transfus Sci; citation_title=Platelet audit: assessment and utilization of this precious resource from a tertiary care hospital; citation_author=K Saluja, B Thakral, N Marwaha, RR Sharma; citation_volume=1; citation_issue=1; citation_publication_date=2007; citation_pages=8-11; citation_id=CR3

Saran RK (2003) Apheresis. In: Saran RK (ed) Transfusion medicine technical manual. Director general of health services, Ministry of health & family welfare, Government of India, New Delhi, pp 229–244

citation_title=Blood component collection by apheresis; citation_inbook_title=AABB Technical manual; citation_publication_date=2014; citation_pages=167-178; citation_id=CR5; citation_author=JW Smith; citation_publisher=Maryland

citation_journal_title=Transfusion; citation_title=German and Austrian plateletpheresis study group. Donor safety in triple plateletpheresis: results from the German and Austrian Plateletpheresis study group multicenter trial; citation_author=H-G Heuft, R Moog, EG Fischer, J Zingsem; citation_volume=53; citation_issue=1; citation_publication_date=2013; citation_pages=211-220; citation_id=CR6

citation_journal_title=Blood; citation_title=Platelet transfusion: a dose-response study; citation_author=F Norol, P Bierling, F Roudot-Thoraval, FF Coeur, C Rieux, A Lavaux; citation_volume=92; citation_issue=4; citation_publication_date=1998; citation_pages=1448-1453; citation_id=CR7

citation_journal_title=Transfusion; citation_title=Clinical consequences of alterations in platelet transfusion dose: a prospective, randomized, double-blind trial; citation_author=TR Klumpp, JH Herman, JP Gaughan, RR Russo, RA Christman, SL Goldberg; citation_volume=39; citation_issue=7; citation_publication_date=1999; citation_pages=674-681; citation_id=CR8

citation_journal_title=Blood; citation_title=Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement; citation_author=SR Hanson, SJ Slichter; citation_volume=66; citation_issue=5; citation_publication_date=1985; citation_pages=1105-1109; citation_id=CR9

citation_journal_title=Indian J Hematol Blood Transfus; citation_title=Double dose plateletpheresis: a savior to shrinking donor pool and platelet inventory management; citation_author=RN Makroo, D Fadadu, S Agrawal, M Chowdhry; citation_volume=34; citation_issue=4; citation_publication_date=2018; citation_pages=691-696; citation_id=CR10

citation_journal_title=Transfus Apher Sci; citation_title=Comparison of double dose plateletpheresis on the fenwal amicus, fresenius com.tec and trima accel cell separators; citation_author=M Keklik, B Eser, L Kaynar, M Solmaz, A Ozturk, M Yay; citation_volume=51; citation_issue=2; citation_publication_date=2014; citation_pages=193-196; citation_id=CR11

citation_journal_title=Transfusion; citation_title=Effects of high-yield thrombocytapheresis on the quality of platelet products; citation_author=F Julmy, RA Ammann, B Mansouri Taleghani, S Fontana, A Hirt, K Leibundgut; citation_volume=48; citation_issue=3; citation_publication_date=2008; citation_pages=442-450; citation_id=CR12

citation_journal_title=Germany. J Clin Apher; citation_title=Evaluation of the performance of Trima Accel® v5.2 for the collection of concentrated high-dose platelet products and concurrent plasma from high platelet count donors, in Germany; citation_author=M Daskalakis, C Schulz-Huotari, M Burger, I Klink, M Umhau; citation_volume=27; citation_issue=2; citation_publication_date=2012; citation_pages=75-80; citation_id=CR13

The drug and cosmetic act and rules (2016) Ministry of health & family welfare, Government of India

citation_journal_title=Transfus Altern Transfus Med; citation_title=Donor safety issues in high-dose platelet collection using the latest apheresis systems; citation_author=R Chaudhary, SS Das, D Khetan, S Ojha, S Verma; citation_volume=11; citation_issue=1; citation_publication_date=2010; citation_pages=1-7; citation_id=CR15

citation_journal_title=Transfus Apher Sci; citation_title=Efficacy of fenwal amicus blood cell separator in double dose platelet collection; citation_author=S Gürak, O Arslan; citation_volume=36; citation_issue=1; citation_publication_date=2007; citation_pages=69-72; citation_id=CR16

citation_journal_title=Transfusion; citation_title=Frequency of immediate adverse effects associated with apheresis donation; citation_author=BC McLeod, TH Price, H Owen, D Ciavarella, I Sniecinski, MJ Randels; citation_volume=38; citation_issue=10; citation_publication_date=1998; citation_pages=938-943; citation_id=CR17

citation_journal_title=Transfus Apher Sci; citation_title=Comparative study of automated plateletpheresis using five different apheresis systems in a tertiary care hospital; citation_author=R Chaudhary, SS Das, D Khetan, S Ojha, S Verma; citation_volume=40; citation_issue=2; citation_publication_date=2009; citation_pages=99-103; citation_id=CR18

citation_journal_title=Transfusion; citation_title=Prospective comparison of high-dose plateletpheresis with the latest apheresis systems on the same donors; citation_author=SM Picker, SM Radojska, BS Gathof; citation_volume=46; citation_issue=9; citation_publication_date=2006; citation_pages=1601-1608; citation_id=CR19

citation_journal_title=J Clin Diagn Res; citation_title=A retrospective analysis of apheresis donor deferral and adverse reactions at a tertiary care centre in India; citation_author=D Arora, K Garg, A Kaushik, R Sharma, DS Rawat, AK Mandal; citation_volume=10; citation_issue=11; citation_publication_date=2016; citation_pages=EC22-EC24; citation_id=CR20

citation_journal_title=Transfus Apher Sci; citation_title=Frequency of adverse events in plateletpheresis donors in regional transfusion centre in North India; citation_author=GK Patidar, RR Sharma, N Marwaha; citation_volume=49; citation_issue=2; citation_publication_date=2013; citation_pages=244-248; citation_id=CR21

citation_journal_title=Indian J Hematol Blood Transfus; citation_title=Adverse events during apheresis procedures: audit at a tertiary hospital; citation_author=K Dogra, P Fulzele, D Rout, R Chaurasia, P Coshic, K Chatterjee; citation_volume=33; citation_issue=1; citation_publication_date=2017; citation_pages=106-108; citation_id=CR22

citation_title=Selection and care of apheresis donors; citation_inbook_title=Apheresis principle and practices; citation_publication_date=2010; citation_pages=111-123; citation_id=CR23; citation_author=C Anderson; citation_publisher=Maryland

citation_journal_title=Transfusion; citation_title=Collection of platelets with a new cell separator and their storage in a citrate-plasticized container; citation_author=TL Simon, ER Sierra, B Ferdinando, R Moore; citation_volume=31; citation_issue=4; citation_publication_date=1991; citation_pages=335-339; citation_id=CR24

citation_title=Whole blood collection and component processing at blood collection centres; citation_inbook_title=AABB Technical manual; citation_publication_date=2011; citation_pages=187-226; citation_id=CR25; citation_author=R Kakaiya; citation_author=J Julleis; citation_publisher=Maryland

citation_journal_title=Surgery; citation_title=Prediction of blood volume in normal human adults; citation_author=SB Nadler, JH Hidalgo, T Bloch; citation_volume=51; citation_issue=2; citation_publication_date=1962; citation_pages=224-232; citation_id=CR26

citation_journal_title=Transfusion; citation_title=Frequently used plateletpheresis techniques result in variable target yields and platelet recruitment of donors; citation_author=EF Strasser, M Schuster, K Egler, J Bauer, V Weisbach, J Ringwald; citation_volume=45; citation_issue=5; citation_publication_date=2005; citation_pages=788-797; citation_id=CR27

citation_journal_title=Transfusion; citation_title=Recruitment of platelets, white blood cells, and hematopoietic progenitor cells during high-yield plateletpheresis; citation_author=S Fontana, L Rados, P Schmid, EO Leibundgut, BM Taleghani; citation_volume=51; citation_issue=9; citation_publication_date=2011; citation_pages=2034-2043; citation_id=CR28

citation_journal_title=Transfusion; citation_title=A rest period before agitation may improve some in vitro apheresis platelet parameters during storage; citation_author=A Skripchenko, A Myrup, H Awatefe, D Thompson-Montgomery, SJ Wagner; citation_volume=52; citation_issue=7; citation_publication_date=2012; citation_pages=1433-1438; citation_id=CR29

citation_journal_title=Vox Sang; citation_title=Effect of EDTA on platelet count and other platelet parameters in blood and blood components collected with CPDA-1; citation_author=RL McShine, PC Das, CT Sibinga, B Brozović; citation_volume=61; citation_issue=2; citation_publication_date=1991; citation_pages=84-89; citation_id=CR30

citation_journal_title=Transfus Med Hemother; citation_title=Platelet recruitment during multiple donor platelet apheresis differs between cell separators; citation_author=S Fontana, P Keller, BM Taleghani; citation_volume=38; citation_issue=3; citation_publication_date=2011; citation_pages=195-198; citation_id=CR31

citation_journal_title=J Clin Apher; citation_title=Apheresis platelets: emerging issues related to donor platelet count, apheresis platelet yield, and platelet transfusion dose; citation_author=LT Goodnough, D Kuter, J McCullough, ME Brecher; citation_volume=13; citation_issue=3; citation_publication_date=1998; citation_pages=114-119; citation_id=CR32

citation_journal_title=J Clin Apher; citation_title=Blood component collection by apheresis; citation_author=EA Burgstaler; citation_volume=21; citation_issue=2; citation_publication_date=2006; citation_pages=142-151; citation_id=CR33

citation_journal_title=Curr Opin Hematol; citation_title=Single donor versus pooled random donor platelet concentrates; citation_author=PM Ness, SA Campbell-Lee; citation_volume=8; citation_issue=6; citation_publication_date=2001; citation_pages=392-396; citation_id=CR34

citation_journal_title=Blood Transfus; citation_title=Pre- and post- donation haematological values in healthy donors undergoing plateletpheresis with five different systems; citation_author=SS Das, R Chaudhary, SK Verma, S Ojha, D Khetan; citation_volume=7; citation_issue=3; citation_publication_date=2009; citation_pages=188-192; citation_id=CR35

citation_journal_title=Vox Sang; citation_title=Analysis of pre- and post-donation haematological values in plateletpheresis donors; citation_author=E Love, K Pendry, L Hunt; citation_volume=65; citation_issue=3; citation_publication_date=1993; citation_pages=209-211; citation_id=CR36

citation_journal_title=Transfus Apher Sci; citation_title=Effect of plateletpheresis on complete blood count values using three different cell separator systems in healthy donors; citation_author=C Beyan, T Cetin, K Kaptan, O Nevruz; citation_volume=29; citation_issue=1; citation_publication_date=2003; citation_pages=45-47; citation_id=CR37

citation_journal_title=Blood; citation_title=The pathophysiology and clinical relevance of platelet heterogeneity; citation_author=CB Thompson, JA Jakubowski; citation_volume=72; citation_issue=1; citation_publication_date=1988; citation_pages=1-8; citation_id=CR38

citation_journal_title=Am J Hematol; citation_title=Evidence for rapid mobilization of platelets from the spleen during intensive plateletpheresis; citation_author=EJ Lee, CA Schiffer; citation_volume=19; citation_issue=2; citation_publication_date=1985; citation_pages=161-165; citation_id=CR39

citation_journal_title=Transfusion; citation_title=Kinetics and mobilization from the spleen of indium-111-labeled platelets during platelet apheresis; citation_author=AD Heyns, PN Badenhorst, MG Lötter, H Pieters, P Wessels; citation_volume=25; citation_issue=3; citation_publication_date=1985; citation_pages=215-218; citation_id=CR40

citation_journal_title=Am J Med Sci; citation_title=Increased splenic pooling and the pathogenesis of hypersplenism; citation_author=JH Jandl, RH Aster; citation_volume=253; citation_issue=4; citation_publication_date=1967; citation_pages=383-398; citation_id=CR41

citation_journal_title=Eur J Haematol; citation_title=The spleen and pooling of blood cells; citation_author=H Wadenvik, J Kutti; citation_volume=41; citation_issue=1; citation_publication_date=1988; citation_pages=1-5; citation_id=CR42

citation_journal_title=Transfus Apher Sci; citation_title=Effectiveness of the Trima Accel cell separator in the double dose plateletpheresis; citation_author=M Keklik, S Korkmaz, U Kalan, M Sarikoc, E Keklik; citation_volume=55; citation_issue=2; citation_publication_date=2016; citation_pages=240-242; citation_id=CR43

citation_journal_title=Transfusion; citation_title=Paired comparison of gambro trima accel versus baxter amicus single-needle plateletpheresis; citation_author=EA Burgstaler, JL Winters, AA Pineda; citation_volume=44; citation_issue=11; citation_publication_date=2004; citation_pages=1612-1620; citation_id=CR44

citation_journal_title=Asian J Transfus Sci; citation_title=Should we reconsider platelet content criteria for single donor platelets in West Bengal, India?; citation_author=R Javed, S Basu; citation_volume=11; citation_issue=1; citation_publication_date=2017; citation_pages=69-70; citation_id=CR45

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Indian Journal of Hematology and Blood Transfusion

Tập 36 Số 3

542-549

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