Analysis of Airborne Biomarkers for Point-of-Care Diagnostics

Liu, 2012, Global, Regional, and National Causes of Child Mortality: An Updated Systematic Analysis for 2010 with Time Trends since 2000, Lancet, 379, 2151, 10.1016/S0140-6736(12)60560-1 Jones, 2003, How Many Child Deaths Can We Prevent This Year?, Lancet, 362, 65, 10.1016/S0140-6736(03)13811-1 2006, Health Workers: A Global Profile, 1 Kost, 2006, Katrina, the Tsunami, and Point-of-Care Testing Optimizing Rapid Response Diagnosis in Disasters, AJCP, 126, 513 Murray, 1997, Alternative Projections of Mortality and Disability by Cause 1990–2020: Global Burden of Disease Study, Lancet, 349, 1498, 10.1016/S0140-6736(96)07492-2 Mathers, 2006, Projections of Global Mortality and Burden of Disease from 2002 to 2030, PLoS Med., 3, e442, 10.1371/journal.pmed.0030442 World Health Organization. Global Tuberculosis Report 2012. http://www.who.int/tb/publications/global_report/en/ (accessed Jun 26, 2013). Golub, 2006, Delayed Tuberculosis Diagnosis and Tuberculosis Transmission, Int. J. Tuberc. Lung Dis., 10 Keeler, 2006, Reducing the Global Burden of Tuberculosis: The Contribution of Improved Diagnostics, Nature, 444, 49, 10.1038/nature05446 Helb, 2010, Rapid Detection of Mycobacterium Tuberculosis and Rifampin Resistance by Use of On-Demand, Near-Patient Technology, J. Clin. Microbiol., 48, 229, 10.1128/JCM.01463-09 World Health Organization. WHO Monitoring of Xpert MTB/RIF Roll-Out. http://who.int/tb/laboratory/mtbrifrollout/en/ (accessed Aug 5, 2013). Pavlou, 2004, Detection of Mycobacterium Tuberculosis (TB) in Vitro and in Situ Using an Electronic Nose in Combination with a Neural Network System, Biosens. Bioelectron., 20, 538, 10.1016/j.bios.2004.03.002 Phillips, 2007, Volatile Biomarkers of Pulmonary Tuberculosis in the Breath, Tuberculosis, 87, 44, 10.1016/j.tube.2006.03.004 Syhre, 2008, The Scent of Mycobacterium Tuberculosis, Tuberculosis, 88, 317, 10.1016/j.tube.2008.01.002 Papineni, 1997, The Size Distribution of Droplets in the Exhaled Breath of Healthy Human Subjects, J. Aerosol Med., 10, 105, 10.1089/jam.1997.10.105 Jensen, 2005 Johnson, 2013, Lifting the Lid on Toilet Plume Aerosol: A Literature Review with Suggestions for Future Research, AJIC, 41, 254 2012 Rafael, 2006, Reducing the Burden of Childhood Malaria in Africa: The Role of Improved Diagnostics, Nature, 39, 10.1038/nature05445 Fung, 2012, Quantitative Detection of PfHRP2 in Saliva of Malaria Patients in the Philippines, Malaria J., 11, 175, 10.1186/1475-2875-11-175 Mharakurwa, S., Simoloka, C., Thuma, P. E., et al. PCR Detection of Plasmodium Falciparum in Human Urine and Saliva Samples. Malaria J. 2006, 5. Jirku, 2012, Detection of Plasmodium Spp. in Human Feces, Emerg. Infect. Dis., 18, 634, 10.3201/eid1804.110984 Wong, 2012, Investigation of Volatile Organic Biomarkers Derived from Plasmodium Falciparum in Vitro, Malaria J., 11, 1, 10.1186/1475-2875-11-314 2002 Bryce, 2005, WHO Estimates of the Causes of Death in Children, Lancet, 365, 1147, 10.1016/S0140-6736(05)71877-8 Lim, 2006, Reducing the Global Burden of Acute Lower Respiratory Infections in Children: The Contribution of New Diagnostics, Nature, 444, 9, 10.1038/nature05442 Tran, 2013, Aerosol-Generating Procedures and Risk of Transmission of Acute Respiratory Infections: A Systematic Review, CADTH Tech. Overviews, 3 Yu, 2004, Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus, NEJM, 350, 1731, 10.1056/NEJMoa032867 Hockstein, 2004, Diagnosis of Pneumonia With an Electronic Nose: Correlation of Vapor Signature with Chest Computed Tomography Scan Findings, Laryngoscope, 114, 1701, 10.1097/00005537-200410000-00005 Fens, 2009, Exhaled Breath Profiling Enables Discrimination of Chronic Obstructive Pulmonary Disease and Asthma, Am. J. Resp. Crit. Care Med., 180, 1076, 10.1164/rccm.200906-0939OC Mazzone, 2010, Chapter 9. Exhaled Volatile Organic Compounds as Biomarkers for Respiratory Diseases, Euro. Resp. Mono., 130 Lozano, 2012, Global and Regional Mortality from 235 Causes of Death for 20 Age Groups in 1990 and 2010: A Systematic Analysis for the Global Burden of Disease Study 2010, Lancet, 380, 2095, 10.1016/S0140-6736(12)61728-0 Fischer Walker, 2010, Etiology of Diarrhea in Older Children, Adolescents and Adults: A Systematic Review, PLoS Negl. Trop. Dis., 4, e768, 10.1371/journal.pntd.0000768 Alam, 2010, Diagnostic Limitations to Accurate Diagnosis of Cholera, J. Clin. Microbiol., 48, 3918, 10.1128/JCM.00616-10 Boncy, 2013, Performance and Utility of a Rapid Diagnostic Test for Cholera: Notes from Haiti, Diag. Microbiol. Infect. Dis., 76, 521, 10.1016/j.diagmicrobio.2013.03.010 Beard, 1965, Aerosol Transmission of Hog Cholera, Cornell Vet., 55, 630 Garner, 2009, A Pilot Study of Faecal Volatile Organic Compounds in Faeces from Cholera Patients in Bangladesh to Determine Their Utility in Disease Diagnosis, Trans. R. Soc. Trop. Med. Hyg., 103, 1171, 10.1016/j.trstmh.2009.02.004 Gallimore, 2006, Environmental Monitoring for Gastroenteric Viruses in a Pediatric Primary Immunodeficiency Unit, J. Clin. Microbiol., 44, 395, 10.1128/JCM.44.2.395-399.2006 Tsai, 1994, Detection of Poliovirus, Hepatitis A Virus, and Rotavirus from Sewage and Ocean Water by Triplex Reverse Transcriptase PCR, Appl. Environ. Microbiol., 60, 2400, 10.1128/aem.60.7.2400-2407.1994 Ganime, 2012, Group A Rotavirus Detection on Environmental Surfaces in a Hospital Intensive Care Unit, Amer. J. Infect. Cont., 40, 544, 10.1016/j.ajic.2011.07.017 Poulton, 1987, Diagnosis of Rotavirus Gastroenteritis by Smell, Arch. Dis. Child., 62, 851, 10.1136/adc.62.8.851 Murray, 2012, Disability-Adjusted Life Years (DALYs) for 291 Diseases and Injuries in 21 Regions, 1990–2010: A Systematic Analysis for the Global Burden of Disease Study 2010, Lancet, 380, 2197, 10.1016/S0140-6736(12)61689-4 Amann, 2011, Lung Cancer Biomarkers in Exhaled Breath, Exp. Rev. Molec. Diag., 11, 207, 10.1586/erm.10.112 Peng, 2010, Detection of Lung, Breast, Colorectal, and Prostate Cancers from Exhaled Breath Using a Single Array of Nanosensors, Brit. J. Cancer, 103, 542, 10.1038/sj.bjc.6605810 Cikach, 2012, Cardiovascular Biomarkers in Exhaled Breath, Prog. Cardio. Dis., 55, 34, 10.1016/j.pcad.2012.05.005 Almstrand, 2009, Airway Monitoring by Collection and Mass Spectrometric Analysis of Exhaled Particles, Anal. Chem., 81, 662, 10.1021/ac802055k Mabey, 2004, Tropical Infectious Diseases: Diagnostics for the Developing World, Nat. Rev. Micro., 2, 231, 10.1038/nrmicro841 Reyburn, 2007, Rapid Diagnostic Tests Compared with Malaria Microscopy for Guiding Outpatient Treatment of Febrile Illness in Tanzania: Randomized Trial, BMJ, 334, 403, 10.1136/bmj.39073.496829.AE Msellem, 2009, Influence of Rapid Malaria Diagnostic Tests on Treatment and Health Outcome in Fever Patients, Zanzibar—a Crossover Validation Study, PLoS Med., 6, e1000070, 10.1371/journal.pmed.1000070 Donlon, 1999, DARPA Integrated Chemical and Biological Detection System, Johns Hopkins APL Tech. Dig., 20, 320 Vincent, 2007 Berkeley, 1874, Memoirs: Atmospheric Micrography, Quart. J. Microscop. Sci., s2-14, 165 Samuelson, 1861, Notes and Memoranda, Quart. J. Microscop. Sci., 61 Reiter, 2000, From Shakespeare to Defoe: Malaria in England in the Little Ice Age, Emerg. Infect. Dis., 6, 1, 10.3201/eid0601.000101 Chapin, 1910 Wells, 1934, On Air-Borne Infection Study II. Droplets and Droplet Nuclei, Am. J. Hyg., 20, 619 Madelin, 1994, Fungal Aerosols: A Review, J. Aeros. Sci., 25, 1405, 10.1016/0021-8502(94)90216-X Esmen, 2002, The Variability of Delivered Dose of Aerosols with the Same Respirable Concentration but Different Size Distributions, Ann. Occup. Hyg., 46, 401 Daigle, 2003, Ultrafine Particle Deposition in Humans During Rest and Exercise, Inhalation toxicology, 15, 539, 10.1080/08958370304468 Lai, 2004, Size and UV Germicidal Irradiation Susceptibility of Serratia Marcescens When Aerosolized from Different Suspending Media, Applied and Environ. Microbiol., 70, 2021, 10.1128/AEM.70.4.2021-2027.2004 Grob, 2008, Biomarkers in Exhaled Breath Condensate: a Review of Collection, Processing and Analysis, J. Breath Res., 2, 037004, 10.1088/1752-7155/2/3/037004 Milstone, 2004, Epidermal Desquamation, J. Derm. Sci., 36, 131, 10.1016/j.jdermsci.2004.05.004 Tham, 2005, Size Relationship Between Airborne Viable Bacteria and Particles in a Controlled Indoor Environment Study, Indoor Air, 15, 48, 10.1111/j.1600-0668.2005.00303.x Castillo, 2012, Exploring the Feasibility of Bioaerosol Analysis as a Novel Fingerprinting Technique, Anal. Bioanal. Chem., 403, 15, 10.1007/s00216-012-5725-0 Pflughoeft, 2012, Human Microbiome in Health and Disease, Ann. Rev. Pathol., 7, 99, 10.1146/annurev-pathol-011811-132421 Barker, 2005, The Potential Spread of Infection Caused by Aerosol Contamination of Surfaces after Flushing a Domestic Toilet, J. Appl. Microbiol., 99, 339, 10.1111/j.1365-2672.2005.02610.x Thomas, 1974, Air Sampling of Smallpox Virus, J. Hygiene, 73, 1, 10.1017/S0022172400023767 Downie, 1965, The Recovery of Smallpox Virus from Patients and Their Environment in a Smallpox Hospital, Bull. World Health Organ., 33, 615 Saldanha, 2008, The Influence of Sampling Duration on Recovery of Culturable Fungi Using the Andersen N6 and RCS Bioaerosol Samplers, Indoor Air, 18, 464, 10.1111/j.1600-0668.2008.00547.x Hanczyc, E. M., Kamholz, A. E., Call, C. J. BioBadge: A Personal Dosimetry Technology for Assessment of Exposures to Biological Agents. In Proc. SPIE 5071, Orlando, FL, April 2003; Carapezza, E. M. (Ed.);; Sep 23, 2003; pp 264–271. Kesavan, 2005 Ryan, 2009, Measurement of Airborne Foot-and-Mouth Disease Virus: Preliminary Evaluation of Two Portable Air Sampling Devices, Vet. J., 179, 458, 10.1016/j.tvjl.2007.10.008 Graham, 2000, The Nasal Air Sampler: A Device for Sampling Inhaled Aeroallergens, Ann. Allergy Asthma Immunol., 84, 599, 10.1016/S1081-1206(10)62410-6 Gore, 2002, Personal Exposure to House Dust Mite Allergen in Bed: Nasal Air Sampling and Reservoir Allergen Levels, Clin. Exper. Allergy, 32, 856, 10.1046/j.1365-2222.2002.01403.x Kennedy, 2000, A New Method To Monitor Airborne Inoculum of the Fungal Plant Pathogens Mycosphaerella brassicicola and Botrytis cinerea, Appl. Environ. Microbiol., 66, 2996, 10.1128/AEM.66.7.2996-3003.2000 Wakeham, 2004, The Collection and Retention of a Range of Common Airborne Spore Types Trapped Directly into Microtiter Wells for Enzyme-linked Immunosorbent Analysis, J. Aeros. Sci., 35, 835, 10.1016/j.jaerosci.2004.01.005 Schmitt, 2010, Gel-based Biochip for the Detection of Airborne Contaminants, Microsys. Tech., 16, 717, 10.1007/s00542-009-0987-y Lindsley, 2006, A Two-stage Cyclone Using Microcentrifuge Tubes for Personal Bioaerosol Sampling, J. Environ. Monit., 8, 1136, 10.1039/b609083d Williams, 2001, Methods for Integrated Air Sampling and DNA Analysis for Detection of Airborne Fungal Spores, Appl. Environ. Microbiol., 67, 2453, 10.1128/AEM.67.6.2453-2459.2001 Skládal, 2012, Electrochemical Immunosensor Coupled to Cyclone Air Sampler for Detection of Escherichia Coli DH5α in Bioaerosols, Electroanalysis, 24, 539, 10.1002/elan.201100448 Hindson, 2005, APDS: The Autonomous Pathogen Detection System, Biosens Bioelectron., 20, 1925, 10.1016/j.bios.2004.09.027 Mainelis, 2005, Performance Characteristics of the Aerosol Collectors of the Autonomous Pathogen Detection System (APDS), Aeros. Sci. Tech., 39, 461, 10.1080/027868290960382 Fabian, 2009, Airborne Influenza Virus Detection with Four Aerosol Samplers Using Molecular and Infectivity Assays: Considerations for a New Infectious Virus Aerosol Sampler, Indoor Air, 19, 433, 10.1111/j.1600-0668.2009.00609.x Willeke, 1998, Improved Aerosol Collection by Combined Impaction and Centrifugal Motion, Aeros. Sci. Tech., 28, 439, 10.1080/02786829808965536 Miljevic, 2009, On the Efficiency of Impingers with Fritted Nozzle Tip for Collection of Ultrafine Particles, Atmosph. Environ., 43, 1372, 10.1016/j.atmosenv.2008.12.001 Hogan, 2005, Sampling Methodologies and Dosage Assessment Techniques for Submicrometre and Ultrafine Virus Aerosol Particles, J. Appl. Microbiol., 99, 1422, 10.1111/j.1365-2672.2005.02720.x Agranovski, 2004, Inactivation of Viruses in Bubbling Processes Utilized for Personal Bioaerosol Monitoring, Applied and Environ. Microbiol., 70, 6963, 10.1128/AEM.70.12.6963-6967.2004 Agranovski, 2005, New Personal Sampler for Viable Airborne Viruses: Feasibility Study, J. Aeros. Sci., 36, 609, 10.1016/j.jaerosci.2004.11.014 Agranovski, 2006, Rapid Detection of Airborne Viruses by Personal Bioaerosol Sampler Combined with the PCR Device, Atmos. Environ., 40, 3924, 10.1016/j.atmosenv.2006.02.023 Pyankov, 2007, Using a Bioaerosol Personal Sampler in Combination with Real-Time PCR Analysis for Rapid Detection of Airborne Viruses, Environ. Microbiol., 9, 992, 10.1111/j.1462-2920.2006.01226.x Usachev, 2012, Portable Automatic Bioaerosol Sampling System for Rapid On-site Detection of Targeted Airborne Microorganisms, J. Environ. Monit., 14, 2739, 10.1039/c2em30317e Zhao, 2008, Droplet Manipulation and Microparticle Sampling on Perforated Microfilter Membranes, J. Micromech. Microeng., 18, 025030, 10.1088/0960-1317/18/2/025030 Nelson, 2012, Droplet Actuation by Electrowetting-on-Dielectric (EWOD): A Review, J. Adhes. Sci. Tech., 26, 1747, 10.1163/156856111X599562 Stewart, 1995, Effect of Impact Stress on Microbial Recovery on an Agar Surface, Appl. Environ. Microbiol., 61, 1232, 10.1128/aem.61.4.1232-1239.1995 Baron, 2001 Mainelis, 1999, Collection of Airborne Microorganisms by Electrostatic Precipitation, Aeros. Sci. Tech., 30, 127, 10.1080/027868299304732 Mainelis, 2002, Design and Collection Efficiency of a New Electrostatic Precipitator for Bioaerosol Collection, Aeros. Sci. Tech., 36, 1073, 10.1080/02786820290092212 Mainelis, 2002, Collection of Airborne Microorganisms by a New Electrostatic Precipitator, J. Aeros. Sci., 33, 1417, 10.1016/S0021-8502(02)00091-5 Yao, 2006, Utilization of Natural Electrical Charges on Airborne Microorganisms for Their Collection by Electrostatic Means, J. Aeros. Sci., 37, 513, 10.1016/j.jaerosci.2005.05.006 Yao, 2009, Comparison of Electrostatic Collection and Liquid Impinging Methods When Collecting Airborne House Dust Allergens, Endotoxin and (1,3)-β-d-glucans, J. Aeros. Sci., 40, 492, 10.1016/j.jaerosci.2009.02.002 Han, 2010, Performance of an Electrostatic Precipitator with Superhydrophobic Surface When Collecting Airborne Bacteria, Aeros. Sci. Tech., 44, 339, 10.1080/02786821003649352 Han, 2008, Design and Development of an Electrostatic Sampler for Bioaerosols with High Concentration Rate, J. Aeros. Sci., 39, 1066, 10.1016/j.jaerosci.2008.07.009 Park, S., Zhang, Y., Lin, S., et al. Advances in Microfluidic PCR for Point-of-care Infectious Disease Diagnostics. Biotechnol. Adv. 2011. Horváth, 2005, Exhaled Breath Condensate: Methodological Recommendations and Unresolved Questions, Euro. Respir. J., 26, 523, 10.1183/09031936.05.00029705 Hippocrates. Aphorisms. http://classics.mit.edu/Hippocrates/aphorisms.html (accessed Dec 20, 2013). Liddell, 1976, Smell as a Diagnostic Marker, Postgrad. Med. J., 52, 136, 10.1136/pgmj.52.605.136 Hayden, 1980, Olfactory Diagnosis in Medicine, Postgrad. Med., 67, 110, 10.1080/00325481.1980.11715427 Michael McCulloch, 2006, Diagnostic Accuracy of Canine Scent Detection in Early- and Late-stage Lung and Breast Cancers, Integ. Cancer Ther., 5 Moser, 2010, Canine Scent Detection of Human Cancers: A Review of Methods and Accuracy, J. Veter. Behav., 5, 145, 10.1016/j.jveb.2010.01.002 Netzer, 2009, A New Ensemble-based Algorithm for Identifying Breath Gas Marker Candidates in Liver Disease Using Ion Molecule Reaction Mass Spectrometry, Bioinformatics, 25, 941, 10.1093/bioinformatics/btp093 Dragonieri, 2007, An Electronic Nose in the Discrimination of Patients with Asthma and Controls, J. Allergy Clin. Immunol., 120, 856, 10.1016/j.jaci.2007.05.043 Aathithan, 2001, Diagnosis of Bacteriuria by Detection of Volatile Organic Compounds in Urine Using an Automated Headspace Analyzer with Multiple Conducting Polymer Sensors, J. Clin. Microbiol., 39, 2590, 10.1128/JCM.39.7.2590-2593.2001 Thaler, 2001, Medical Applications of Electronic Nose Technology: Review of Current Status, Amer. J. Rhinol., 15, 291, 10.1177/194589240101500501 Mahmoudi, 2009, Electronic Nose Technology and Its Applications, Sensors Transd., 107, 17 Turner, 2004, Electronic Noses and Disease Diagnostics, Nat. Rev. Microbiol., 2, 161, 10.1038/nrmicro823 Wilson, 2009, Applications and Advances in Electronic-Nose Technologies, Sensors, 9, 5099, 10.3390/s90705099 Lisboa, 2002, A Review of Evidence of Health Benefit from Artificial Neural Networks in Medical Intervention, Neural Net., 15, 11, 10.1016/S0893-6080(01)00111-3 Wilson, 2011, Advances in Electronic-Nose Technologies Developed for Biomedical Applications, Sensors, 11, 1105, 10.3390/s110101105 Chountas, P., Kodogiannis, V. Development of a Clinical Data Warehouse. In IDEAS Workshop on Medical Information Systems: The Digital Hospital; Desai, B. C. (Ed.); IEEE Computer Society, Washington, DC, pp. 8–14. Smith, 2006, From Concepts to Clinical Reality: An Essay on the Benchmarking of Biomedical Terminologies, J. Biomed. Inform., 39, 288, 10.1016/j.jbi.2005.09.005 Arshak, 2004, A Review of Gas Sensors Employed in Electronic Nose Applications, Sensor Rev., 24, 181, 10.1108/02602280410525977 Handbook of Modern Sensors: Physics, Designs, and Applications. http://www.springer.com/physics/applied+%26+technical+physics/book/978-1-4419-6465-6 (accessed Aug 7, 2013). Principles of Chemical Sensors. http://www.springer.com/chemistry/analytical+chemistry/book/978-0-387-69930-1 accessed Aug 7, 2013). Zhang, X., Ju, H., Wang, J. Electrochemical Sensors, Biosensors and Their Biomedical Applications. http://researchcoindia.com/books_details.aspx?Book_Number=24937 (accessed Aug 7, 2013). Baldini, A. F. Continuous Monitoring of Gastric Carbon Dioxide with Optical Fibres. Sens. Act. B. Chem. 132–138. Optical CO2-sensing layers for clinical application based on pH-sensitive indicators incorporated into nanoscopic metal-oxide supports - 驰群的日志 - 网易博客 http://blog.163.com/nucliqiang2@126/blog/static/51223412200792423632116/ (accessed Aug 7, 2013). Kudo, 2010, Fiber-Optic Bio-Sniffer (Biochemical Gas Sensor) for High-Selective Monitoring of Ethanol Vapor Using 335nm UV-LED, Sens. Act. B. Chem., 147, 676, 10.1016/j.snb.2010.03.066 Wen, 2009, Development of a Sensitive Gas Sensor by Trapping the Analytes on Nanomaterials and in Situ Cataluminescence Detection, Sens. Act. B. Chem., 141, 168, 10.1016/j.snb.2009.06.014 Shorter, 2009, Multicomponent Breath Analysis With Infrared Absorption Using Room-Temperature Quantum Cascade Lasers, IEEE Sens. J., 10, 76, 10.1109/JSEN.2009.2035764 Minamide, 2005, Bioelectronic Detector with Monoamine Oxidase for Halitosis Monitoring, Analyst, 130, 1490, 10.1039/b506748k M Maniscalco, 2008, Validation Study of Nasal Nitric Oxide Measurements Using a Hand-held Electrochemical Analyser, Euro. J. Clin. Invest., 38, 197, 10.1111/j.1365-2362.2008.01907.x Fritsch, 2008, Is Exhaled Carbon Monoxide Level Associated with Blood Glucose Level? A Comparison of Two Breath Analyzing Methods, J Biomed Opt, 13, 034012, 10.1117/1.2937215 Sylvester, 2005, Exhaled Carbon Monoxide Levels in Children with Sickle Cell Disease, Euro. J. Pediatr., 164, 162, 10.1007/s00431-004-1605-8 Alving, 2006, Performance of a New Hand-held Device for Exhaled Nitric Oxide Measurement in Adults and Children, Resp. Res., 7, 67, 10.1186/1465-9921-7-67 Boot, 2008, Comparison of Exhaled Nitric Oxide Measurements Between NIOX MINO® Electrochemical and Ecomedics Chemiluminescence Analyzer, Resp. Med., 102, 1667, 10.1016/j.rmed.2008.06.021 Hemmingsson, 2004, Novel Hand-held Device for Exhaled Nitric Oxide-analysis in Research and Clinical Applications, J. Clin. Monit. Comput., 18, 379, 10.1007/s10877-005-1158-z Schneider, 2009, Diagnosing Asthma in General Practice with Portable Exhaled Nitric Oxide Measurement—Results of a Prospective Diagnostic Study: FENO ≤ 16 Ppb Better than FENO ≤ 12 Ppb to Rule Out Mild and Moderate to Severe Asthma, Resp. Res., 10, 64, 10.1186/1465-9921-10-64 Fend, 2006, Prospects for Clinical Application of Electronic-Nose Technology to Early Detection of Mycobacterium Tuberculosis in Culture and Sputum, J. Clin. Microbiol., 44, 2039, 10.1128/JCM.01591-05 Ritaban Dutta, D. M. Identification of Staphylococcus Aureus Infections in Hospital Environment: Electronic Nose Based Approach. Sens. Act. B. Chem. 355–362. Shykhon, 2004, Clinical Evaluation of the Electronic Nose in the Diagnosis of Ear, Nose and Throat Infection: A Preliminary Study, J. Laryng. Otol., 118, 706, 10.1258/0022215042244660 Machado, 2005, Detection of Lung Cancer by Sensor Array Analyses of Exhaled Breath, Am. J. Respir. Crit. Care Med., 171, 1286, 10.1164/rccm.200409-1184OC Yates, 2005, Data Reduction in Headspace Analysis of Blood and Urine Samples for Robust Bacterial Identification, Comp. Meth. Prog. Biomed., 79, 259, 10.1016/j.cmpb.2005.04.003 Kateb, 2009, Sniffing Out Cancer Using the JPL Electronic Nose: a Pilot Study of a Novel Approach to Detection and Differentiation of Brain Cancer, Neuroimage, 47, T5, 10.1016/j.neuroimage.2009.04.015 Haick, 2009, Sniffing Chronic Renal Failure in Rat Model by an Array of Random Networks of Single-Walled Carbon Nanotubes, ACS Nano, 3, 1258, 10.1021/nn9001775 Gouma, 2010, Nanosensor and Breath Analyzer for Ammonia Detection in Exhaled Human Breath, IEEE Sens. J., 10, 49, 10.1109/JSEN.2009.2036050 Neri, 2010, Design and Development of a Breath Acetone MOS Sensor for Ketogenic Diets Control, IEEE Sens. J., 10, 131, 10.1109/JSEN.2009.2035663 Groves, 2004, Laboratory and Field Evaluation of a SAW Microsensor Array for Measuring Perchloroethylene in Breath, J. Occup. Environ. Hyg., 1, 779, 10.1080/15459620490885626 Groves, 2001, Analysis of Solvent Vapors in Breath and Ambient Air with a Surface Acoustic Wave Sensor Array, Ann. Occup. Hyg., 45, 609, 10.1016/S0003-4878(01)00020-5 Fernandes, 2009, A New Analytical System, Based on an Acoustic Wave Sensor, for Halitosis Evaluation, Sens. Act. B. Chem., 136, 73, 10.1016/j.snb.2008.10.037 Sivaramakrishnan, 2008, Carbon Nanotube-coated Surface Acoustic Wave Sensor for Carbon Dioxide Sensing, Sens. Act. B. Chem., 132, 296, 10.1016/j.snb.2008.01.041 Saraoglu, 2010, Determination of Blood Glucose Level-Based Breath Analysis by a Quartz Crystal Microbalance Sensor Array, IEEE Sens. J., 10, 104, 10.1109/JSEN.2009.2035769 Pennazza, 2008, Application of a Quartz Microbalance Based Gas Sensor Array for the Study of Halitosis, J. Breath Res., 2, 017009, 10.1088/1752-7155/2/1/017009 Payne, 1989, Transducers, Sensors, and Instrumentation in Clinical Biomechanics, J. Biomed. Eng., 11, 180, 10.1016/0141-5425(89)90137-4 Adewale, 2004, An Internet-based Telemedicine System in Nigeria, Int. J. Info. Manag., 24, 221, 10.1016/j.ijinfomgt.2003.12.014 Wilson, 2004, Development of Conductive Polymer Analysis for the Rapid Detection and Identification of Phytopathogenic Microbes, Phytopathology, 94, 419, 10.1094/PHYTO.2004.94.5.419 Kostelc, 1980, Salivary Volatiles as Indicators of Periodontitis, J. Periodont. Res., 15, 185, 10.1111/j.1600-0765.1980.tb00273.x Dutta, 2002, Bacteria Classification Using Cyranose 320 Electronic Nose, BioMed. Eng. OnLine, 1, 4, 10.1186/1475-925X-1-4 Matsumoto, 1973, The Identification of Volatile Compounds in Human Urine, J. Chromatogr., 85, 31, 10.1016/S0021-9673(01)91861-8 J B Sidbury, 1967, An Inborn Error of Short-chain Fatty Acid Metabolism. The Odor-of-sweaty-feet Syndrome, J. Pediat., 70, 8, 10.1016/S0022-3476(67)80160-4 Witt, 2010, Application of an Electronic Nose to Diagnose Liver Cirrhosis from the Skin Surface, 150 Conkle, 1975, Trace Composition of Human Respiratory Gas, Arch. Environ. Health, 30, 290, 10.1080/00039896.1975.10666702 Novotny, 1974, Some Analytical Aspects of the Chromatographic Headspace Concentration Method Using a Porous Polymer, Chromatographia, 7, 333, 10.1007/BF02269346 Pauling, 1971, Quantitative Analysis of Urine Vapor and Breath by Gas-liquid Partition Chromatography, Proc. Natl. Acad. Sci. U.S.A., 68, 2374, 10.1073/pnas.68.10.2374 Henderson, 1952, Acetone in the Breath; a Study of Acetone Exhalation in Diabetic and Nondiabetic Human Subjects, Diabetes, 1, 188, 10.2337/diab.1.3.188 Teshima, 2005, Determination of Acetone in Breath, Analytica Chimica Acta, 535, 189, 10.1016/j.aca.2004.12.018 Sanchez, 2003, GC Analysis of Human Breath with a Series-coupled Column Ensemble and a Multibed Sorption Trap, Anal. Chem., 75, 2231, 10.1021/ac020725g Lärstad, 2002, Determination of Ethane, Pentane and Isoprene in Exhaled Air Using a Multi-bed Adsorbent and End-cut Gas-solid Chromatography, Analyst, 127, 1440, 10.1039/B205994K Phillips, 1992, Ion-trap Detection of Volatile Organic Compounds in Alveolar Breath, Clin. Chem., 38, 60, 10.1093/clinchem/38.1.60 Giardina, 2003, Application of Low-temperature Glassy Carbon-coated Macrofibers for Solid-phase Microextraction Analysis of Simulated Breath Volatiles, Anal. Chem., 75, 1604, 10.1021/ac025984k Grote, 1997, Solid-phase Microextraction for the Analysis of Human Breath, Anal. Chem., 69, 587, 10.1021/ac960749l Miekisch, 2001, Analysis of Volatile Disease Markers in Blood, Clin. Chem., 47, 1053, 10.1093/clinchem/47.6.1053 Miekisch, 2004, Diagnostic Potential of Breath Analysis: Focus on Volatile Organic Compounds, Clin. Chim. Acta, 347, 25, 10.1016/j.cccn.2004.04.023 Lord, 2002, Breath Analysis and Monitoring by Membrane Extraction with Sorbent Interface, Anal. Chem., 74, 5650, 10.1021/ac025863k Gibson, T. D., Prosser, O. Detection and Simultaneous Identification of Microorganisms from Headspace Samples Using an Electronic Nose. Sens. Act. B. Chem. 413–422. Gardner, 2000, Detection of Bacteria Causing Eye Infections Using a Neural Network Based Electronic Nose System, 189 2005 Mashir, 2009, Exhaled Breath Analysis: The New Interface Between Medicine and Engineering, Adv. Powder Technol., 20, 420, 10.1016/j.apt.2009.05.003 Pleil, 1997, Exhaled Human Breath Measurement Method for Assessing Exposure to Halogenated Volatile Organic Compounds, Clin. Chem., 43, 723, 10.1093/clinchem/43.5.723 Schubert, 2001, CO(2)-controlled Sampling of Alveolar Gas in Mechanically Ventilated Patients, J. Appl. Physiol., 90, 486, 10.1152/jappl.2001.90.2.486 Thaler, 2009, The Diagnostic Utility of an Electronic Nose: Rhinologic Applications, Laryngoscope, 112, 1533, 10.1097/00005537-200209000-00002 Ping, 1997, A Novel Method for Diabetes Diagnosis Based on Electronic Nose, Biosens. Bioelectr., 12, 1031, 10.1016/S0956-5663(97)00059-6 Hockstein, 2005, Correlation of Pneumonia Score with Electronic Nose Signature: A Prospective Study, Ann. Otol. Rhinol. Laryngol., 114, 504, 10.1177/000348940511400702 Hanson, 2005, Electronic Nose Prediction of a Clinical Pneumonia Score: Biosensors and Microbes, Anesthesiology, 102, 63, 10.1097/00000542-200501000-00013 Guo, D., Zhang, D., Li, N., et al. A Novel Breath Analysis System Based on Electronic Olfaction. IEEE Trans. Biomed. Eng. 2010. Phillips, 2003, Detection of Lung Cancer with Volatile Markers in the Breath, Chest, 123, 2115, 10.1378/chest.123.6.2115 Di Natale, 2003, Lung Cancer Identification by the Analysis of Breath by Means of an Array of Non-selective Gas Sensors, Biosens. Bioelectron., 18, 1209, 10.1016/S0956-5663(03)00086-1 D’Amico, 2010, An Investigation on Electronic Nose Diagnosis of Lung Cancer, Lung Cancer, 68, 170, 10.1016/j.lungcan.2009.11.003 A study of an electronic nose for detection of lung cancer based on a virtual SAW gas sensors array and imaging recognition method - Abstract - Measurement Science and Technology - IOPscience http://iopscience.iop.org/0957-0233/16/8/001/ (accessed Aug 7, 2013). Paolo Montuschi, 2010, Diagnostic Performance of an Electronic Nose, Fractional Exhaled Nitric Oxide, and Lung Function Testing in Asthma, Chest, 137 Phillips, 2012, Point-of-care Breath Test for Biomarkers of Active Pulmonary, Tuberculosis, 92, 314, 10.1016/j.tube.2012.04.002 Mohamed, 2003, A Novel Method for Diagnosing Chronic Rhinosinusitis Based on an Electronic Nose, An. Otorrinolaringol. Ibero. Am., 30, 447 Bruno, 2008, Can the Electronic Nose Diagnose Chronic Rhinosinusitis? A New Experimental Study, Euro. Arch. Otorhinolaryngol., 265, 425, 10.1007/s00405-007-0477-8 Corrado Di Natale, A. M. Human Skin Odor Analysis by Means of an Electronic Nose. Sens. Act. B. Chem. 216–219. Boilot, 2002, Classification of Bacteria Responsible for ENT and Eye Infections Using the Cyranose System, IEEE Sens. J., 2, 247, 10.1109/JSEN.2002.800680 Byun, 2010, Wound-State Monitoring for Burn Patients Using E-Nose/SPME System, ETRI J., 32, 440, 10.4218/etrij.10.0109.0300 D’Amico, 2008, Identification of Melanoma with a Gas Sensor Array, Skin Res. Technol., 14, 226, 10.1111/j.1600-0846.2007.00284.x Banday, 2011, Use of Urine Volatile Organic Compounds To Discriminate Tuberculosis Patients from Healthy Subjects, Anal. Chem., 83, 5526, 10.1021/ac200265g Pavlou, 2002, Recognition of Anaerobic Bacterial Isolates in Vitro Using Electronic Nose Technology, Lett. Appl. Microbiol., 35, 366, 10.1046/j.1472-765X.2002.01197.x Lin, 2001, Application of the Electronic Nose for Uremia Diagnosis, Sens. Act. B. Chem., 76, 177, 10.1016/S0925-4005(01)00625-6 M. Bernabei, G. P. A Preliminary Study on the Possibility to Diagnose Urinary Tract Cancers by an Electronic Nose. Sens. Act. B. Chem. 1–4. Cong, H., Pan, T. Microfabrication of Conductive PDMS on Flexible Substrates for Biomedical Applications. In 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 2009. NEMS 2009; 2009; pp. 731–734. Ha, 2005, Integrated and Microheater Embedded Gas Sensor Array Based on the Polymer Composites Dispensed in Micromachined Wells, Sens. Act. B. Chem., 105, 549, 10.1016/j.snb.2004.01.019 Su, 2003, Miniaturized Chemical Multiplexed Sensor Array, J. Amer. Chem. Soc., 125, 9930, 10.1021/ja035727c Rapp, 2000, New Miniaturized SAW-sensor Array for Organic Gas Detection Driven by Multiplexed Oscillators, Sens. Act. B. Chem., 65, 169, 10.1016/S0925-4005(99)00321-4 Zampetti, 2008, Use of a Multiplexed Oscillator in a Miniaturized Electronic Nose Based on a Multichannel Quartz Crystal Microbalance, Sens. Act. B. Chem., 131, 159, 10.1016/j.snb.2007.12.011 Yang, 2006, A Portable Electronic Nose (E-Nose) System Based on PDA, Lect. Notes Comp. Sci., 974, 10.1007/11840817_101 Chang, 2006, Printable Polythiophene Gas Sensor Array for Low-cost Electronic Noses, J. Appl. Phys., 100, 014506, 10.1063/1.2208743 Mazzone, 2007, Diagnosis of Lung Cancer by the Analysis of Exhaled Breath with a Colorimetric Sensor Array, Thorax, 62, 565, 10.1136/thx.2006.072892 Parry, 1995, Leg Ulcer Odour Detection Identifies Beta-haemolytic Streptococcal Infection, J. Wound Care, 4, 404, 10.12968/jowc.1995.4.9.404 Pavlou, A., Turner, A., Barr, H. Diagnosis of Gastric and Lung Disorders. WO Patent WO/2000/032091, June 9, 2000. McDevitt, 2013, Development and Performance Evaluation of an Exhaled-Breath Bioaerosol Collector for Influenza Virus, Aeros. Sci. Tech., 47, 444, 10.1080/02786826.2012.762973 Roy, 2004, Airborne Transmission of Communicable Infection—the Elusive Pathway, NEJM, 350, 1710, 10.1056/NEJMp048051 D’Amico, 2012, Detection and Identification of Cancers by the Electronic Nose, Exp. Opin. Med. Diag., 6, 175, 10.1517/17530059.2012.665870 Hindson, 2005, APDS: The Autonomous Pathogen Detection System, Biosens. Bioelectr., 20, 1925, 10.1016/j.bios.2004.09.027 Agranovski, 2002, Collection of Airborne Microorganisms into Liquid by Bubbling through Porous Medium, Aeros. Sci. Tech., 36, 502, 10.1080/027868202753571322 Pavlou, 2000, An Intelligent Rapid Odour Recognition Model in Discrimination of Helicobacter Pylori and Other Gastroesophageal Isolates in Vitro, Biosens. Bioelectron., 15, 333, 10.1016/S0956-5663(99)00035-4 Pavlou, 2002, Use of an Electronic Nose System for Diagnoses of Urinary Tract Infections, Biosens. Bioelectr., 17, 893, 10.1016/S0956-5663(02)00078-7 Lai, 2002, Identification of Upper Respiratory Bacterial Pathogens with the Electronic Nose, Laryngoscope, 112, 975, 10.1097/00005537-200206000-00007 Greenwood, 1997, Monitoring Wound Healing by Odour, J. Wound Care, 6, 219, 10.12968/jowc.1997.6.5.219 Voss, 2005, Smelling Renal Dysfunction via Electronic Nose, Ann. Biomed. Eng., 33, 656, 10.1007/s10439-005-1438-2 Gardner, 2000, An Electronic Nose System to Diagnose Illness, Sens. Act. B. Chem., 70, 19, 10.1016/S0925-4005(00)00548-7 Bruins, 2009, Device-independent, Real-time Identification of Bacterial Pathogens with a Metal Oxide-based Olfactory Sensor, Eur. J. Clin. Microbiol. Infect. Dis., 28, 775, 10.1007/s10096-009-0700-1 Moens, 2006, Fast Identification of Ten Clinically Important Micro-organisms Using an Electronic Nose, Lett. Appl. Microbiol., 42, 121, 10.1111/j.1472-765X.2005.01822.x Casalinuovo, 2006, Experimental Use of a New Surface Acoustic Wave Sensor for the Rapid Identification of Bacteria and Yeasts, Lett. Appl. Microbiol., 42, 24, 10.1111/j.1472-765X.2005.01792.x