An efficient nonenzymatic conversion of benzylpenicillin to 6‐aminopenicillanic acid

Wiley - Tập 89 Số 10 - Trang 1081-1084 - 1970
Helmut Weißenburger1,2, Marcel G. van der Hoeven2
1Deceased (28th of November 1969).
2Research Laboratories of the Royal Netherlands Fermentation Industries, Delft, The Netherlands

Tóm tắt

AbstractAn efficient procedure for the chemical conversion of benzylpenicillin to 6‐aminopenicillanic acid is described. The selective cleavage of the amide bond has been accomplished by treating the silyl ester of benzylpenicillin consecutively with phosphorus pentachloride, n‐butanol and water at low temperatures.

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Tài liệu tham khảo

10.1038/183257b0

10.1038/187236a0

10.1038/187237a0

10.1021/ja01499a083

10.1007/BF00638300

10.1038/1951000a0

10.1021/jo01346a027

10.1021/ja00876a034

10.1021/ja01034a022

10.1002/hlca.19680510513

10.1002/ange.19560681406

Glaxo Labs., Belg., 719, 712

CIBA Ltd. Neth. appl. 68 12413 (appl. 1‐9‐1967).

Koninklijke Nederlandsche Gist‐ en Spiritusfabriek N.V. Neth. appl. 67 10835 (appl. 7‐81967);

1969, Chem. Abstr., 71, 61403

J. G.Oostendorp to be published.

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Wiley

Tập 89 Số 10

1081-1084

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