Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot

Journal of Child Psychology and Psychiatry and Allied Disciplines - Tập 50 Số 8 - Trang 943-951 - 2009
Mitul A. Mehta1, Nicole I. Golembo1, Chiara Nosarti2, Emma Colvert3, Ashley Mota1, Steven Williams1, Michael Rutter3, Edmund Sonuga‐Barke4,5,3
1Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College, London, UK
2Division of Psychological Medicine, Institute of Psychiatry, King's College, London, UK
3MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College, London, UK
4Department of Experimental Clinical & Health Psychology, Ghent University, Belgium
5Developmental Brain-Behaviour Laboratory, School of Psychology, University of Southampton, UK

Tóm tắt

The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development. This cross‐sectional study was a pilot for a planned larger study quantifying the effects of early deprivation on later brain structure. We used magnetic resonance imaging (MRI) to measure the sizes of three key brain regions hypothesized to be sensitive to early adverse experiences. Our sample was a group of adoptee adolescents (N = 14) who had experienced severe early institutional deprivation in Romania and a group of non‐institutionalised controls (N = 11). The total grey and white matter volumes were significantly smaller in the institutionalised group compared with a group of non‐deprived, non‐adopted UK controls. After correcting for difference in brain volume, the institutionalised group had greater amygdala volumes, especially on the right, but no differences were observed in hippocampal volume or corpus callosum mid‐sagittal area. The left amygdala volume was also related to the time spent in institutions, with those experiencing longer periods of deprivation having a smaller left amygdala volume. These pilot findings highlight the need for future studies to confirm the sensitivity of the amygdala to early deprivation.

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Journal of Child Psychology and Psychiatry and Allied Disciplines

Tập 50 Số 8

943-951

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