Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa

International Journal of Eating Disorders - Tập 45 Số 2 - Trang 263-271 - 2012
Ursula F. Bailer1,2, Rajesh Narendran3,4, W. Gordon Frankle3,4, Michael L. Himes3, Vikas Duvvuri2, Chester A. Mathis4, Walter H. Kaye2
1Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
2Department of Psychiatry, University of California, San Diego, La Jolla, California
3Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, School of Medicine, University of Pittsburgh, Pennsylvania
4Department of Radiology, School of Medicine, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania

Tóm tắt

AbstractObjective:Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function.Method:We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW).Results:REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria (r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate (r = −0.62, p = 0.05).Discussion:REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food‐related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)

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Tài liệu tham khảo

10.1176/appi.books.9780890423349

10.1176/ajp.148.12.1627

10.1146/annurev.med.51.1.465

10.1001/archpsyc.63.3.305

10.1002/eat.20251

10.1017/S0033291704002442

10.1016/j.cpr.2005.10.003

10.1176/appi.ajp.160.2.366

10.1016/j.physbeh.2007.11.037

10.2174/1389450043490541

10.1002/syn.10075

10.1038/sj.npp.1300719

10.1016/S0195-6663(02)00138-1

10.1017/S0033291706008129

10.1016/S0893-133X(99)00053-6

10.1016/j.biopsych.2005.05.003

BailerUF FrankGK PriceJC MeltzerCC BeckerCR Mathis CA WagnerA et al.Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa (submitted).

10.1152/jn.2000.84.6.3072

10.1038/nature03015

Schultz W, 2004, Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology, Science, 14, 139

10.1073/pnas.94.6.2569

10.1002/(SICI)1098-2396(199701)25:1<1::AID-SYN1>3.0.CO;2-H

10.1016/j.biopsych.2005.04.044

10.1097/01.WCB.0000048520.34839.1A

10.1016/S0006-3223(02)01378-1

10.1038/sj.npp.1300430

10.1001/archpsyc.62.9.1032

10.1016/j.biopsych.2006.07.018

10.1007/s00213-007-0896-7

10.1016/0883-2897(91)90096-4

10.1038/sj.jcbfm.9600493

10.1002/syn.20633

10.1124/jpet.109.163501

10.1097/00004647-200109000-00002

10.1038/sj.npp.1300916

10.1007/BF00177923

Wolkin A, 1994, Acute d‐amphetamine challenge in schozophrenia: effects on cerebral glucose utilization and clinical symptomatology, Psychol Med, 35, 649

10.1038/sj.npp.1301400

10.1007/s00213-002-1040-3

10.1006/nimg.1996.0066

Cohen J, 1988, Statistical Power Analysis for Behavioral Sciences

Laruelle M, 1995, SPECT imaging of striatal dopamine release after amphetamine challenge, J Nucl Med., 36, 1182

Volkow N, 1999, Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors, J Pharmacol Exp Ther, 291, 409

10.1016/S0006-3223(00)01038-6

10.1016/0006-3223(95)00110-7

10.1016/0376-8716(86)90068-2

10.1037/1064-1297.11.1.91

10.1007/BF02246020

10.1037/1064-1297.7.4.493

10.1016/S0091-3057(02)00818-3

10.1176/appi.ajp.2007.07040575

10.1002/eat.10135

Strober M, 1995, Eating Disorders and Obesity‐A Comprehensive Handbook, 212

Vitousek K, 1994, Personality variables and disorders in anorexia nervosa and bulimia nervosa, J Abnorm Psychol, 103, 137, 10.1037/0021-843X.103.1.137

10.1016/S0306-4522(98)00583-1

10.1176/appi.ajp.2008.07121900

10.1152/jn.1998.80.1.1

10.1523/JNEUROSCI.2058-08.2008

10.1176/appi.ajp.2008.08050775

10.1016/S0893-133X(99)00079-2

10.1016/S0893-133X(02)00366-4

10.1038/sj.npp.1301565

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International Journal of Eating Disorders

Tập 45 Số 2

263-271

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