Amelioration of oxidative stress in red blood cells from patients with β‐thalassemia major and intermedia and E‐β‐thalassemia following administration of a fermented papaya preparation

Phytotherapy Research - Tập 24 Số 9 - Trang 1334-1338 - 2010
Eitan Fibach1, Ee‐Shien Tan2, Saumya Shekhar Jamuar2, Ivy Ng2, Johnny Amer1, Eliezer A. Rachmilewitz3
1Department of Hematology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
2Department of Paediatric Medicine and Genetics Service, KK Women's and Children's Hospital, Singapore
3Department of Hematology, The E. Wolfson Medical Center, Holon, Israel

Tóm tắt

AbstractIn β‐hemoglobinopathies, such as β‐thalassemia (thal) and sickle cell anemia, the primary defects are mutations in the β‐globin gene. However, many aspects of the pathophysiology are mediated by oxidative stress. Fermented papaya preparation (FPP), a natural health food product obtained by biofermentation of carica papaya, has been shown to limit oxidative stress both in vitro and in vivo. We studied the effect of FPP on two groups of β‐thal patients: β‐thal, major and intermedia, (in Israel) and E‐β‐thal (in Singapore). The results indicated that in both groups FPP treatment increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased their reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), indicating amelioration of their oxidative status, without a significant change in the hematological parameters. Since the turnover of the erythron is relatively slow, it is possible that longer duration of treatment, probably with the addition of an iron chelator, is required in order to achieve the latter goals. Copyright © 2010 John Wiley & Sons, Ltd.

Từ khóa


Tài liệu tham khảo

10.1016/j.bbagen.2007.11.009

10.1160/TH04-04-0234

10.1111/j.1365-2141.2005.05463.x

10.1111/j.1365-2141.2005.05834.x

10.1034/j.1600-0609.2003.00011.x

10.1002/cyto.a.20017

10.1007/s00421-005-0010-y

10.1182/blood.V99.1.36

10.1046/j.1365-2362.2002.0320s1042.x

10.2174/156652408786241384

10.1182/blood.V92.9.3007

10.1172/JCI110724

Imao K, 1998, Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide level and superoxide dismutase activity in iron‐induced epileptic foci of rats, Biochem Mol Biol Int, 45, 11

10.1016/S0891-5849(96)00488-1

Marcocci L, 1996, Efficacy of Bio‐Catalyzer alpha.rho no.11 (Bio‐Normalizer) supplementation against peroxyl radical‐induced oxidative damage in rat organ homogenates, Biochem Mol Biol Int, 38, 535

Marotta F, 1997, Abstinence‐induced oxidative stress in moderate drinkers is improved by bionormalizer, Hepatogastroenterology, 44, 1360

Osato JA, 1995, Effects of bio‐normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages, Nutrition, 11, 568

Rachmilewitz EA, 2001, Disorders of hemoglobin: genetics, 233

10.1056/NEJMra050436

10.1016/0891-5849(91)90154-U

Shinar E, 1990, Oxidative denaturation of red blood cells in thalassemia, Semin Hematol, 27, 70

10.1080/10715760600554228

10.2174/157340609789117912

10.1080/1024533031000081414

Thông tin
Thông tin xuất bản

Phytotherapy Research

Tập 24 Số 9

1334-1338

Thông tin tác giả