Alzheimer's Disease: The Amyloid Cascade Hypothesis

American Association for the Advancement of Science (AAAS) - Tập 256 Số 5054 - Trang 184-185 - 1992
John Hardy1, Gerald A. Higgins2
1Department of Biochemistry, St. Mary's Hospital Medical School, London, U.K.
2NATIONAL INSTITUTES OF HEALTH

Tóm tắt

Từ khóa


Tài liệu tham khảo

ABE, K, INDUCTION OF AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER HEAT-SHOCK IN CULTURED HUMAN LYMPHOBLASTOID-CELLS, NEUROSCIENCE LETTERS 125: 169 (1991).

ABE, K, SELECTIVE INDUCTION OF KUNITZ-TYPE PROTEASE INHIBITOR DOMAIN-CONTAINING AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER PERSISTENT FOCAL ISCHEMIA IN RAT CEREBRAL-CORTEX, NEUROSCIENCE LETTERS 125: 172 (1991).

ANDERSON, J.P., EXACT CLEAVAGE SITE OF ALZHEIMER AMYLOID PRECURSOR IN NEURONAL PC-12 CELLS, NEUROSCIENCE LETTERS 128: 126 (1991).

BAUDIER, J, PHOSPHORYLATION OF TAU-PROTEINS TO A STATE LIKE THAT IN ALZHEIMERS BRAIN IS CATALYZED BY A CALCIUM CALMODULIN-DEPENDENT KINASE AND MODULATED BY PHOSPHOLIPIDS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 17577 (1987).

10.1192/bjp.114.512.797

10.1038/353844a0

10.1126/science.2111583

10.1126/science.1738846

GANDY, S, JOURNAL OF CELL BIOLOGY 115: 122a (1991).

10.1016/S0006-291X(84)80190-4

10.1016/0006-291X(84)91209-9

10.1038/349704a0

GOEDERT, M, MULTIPLE ISOFORMS OF HUMAN MICROTUBULE-ASSOCIATED PROTEIN-TAU - SEQUENCES AND LOCALIZATION IN NEUROFIBRILLARY TANGLES OF ALZHEIMERS-DISEASE, NEURON 3: 519 (1989).

10.1126/science.1738847

GOLDGABER, D, INTERLEUKIN-1 REGULATES SYNTHESIS OF AMYLOID BETA-PROTEIN PRECURSOR MESSENGER-RNA IN HUMAN-ENDOTHELIAL CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 7606 (1989).

10.1126/science.3810169

GREENBERG, B.D., SOC NEUR ABSTR 17: 913 (1991).

HAASS, C, PROCESSING OF BETA-AMYLOID PRECURSOR PROTEIN IN MICROGLIA AND ASTROCYTES FAVORS AN INTERNAL LOCALIZATION OVER CONSTITUTIVE SECRETION, JOURNAL OF NEUROSCIENCE 11: 3783 (1991).

HARDY, J, MOLECULAR CLASSIFICATION OF ALZHEIMERS-DISEASE, LANCET 337: 1342 (1991).

10.1126/science.2111579

10.1038/325733a0

KATZMAN, R, ADVANCES IN ALZHEIMERS-DISEASE, FASEB JOURNAL 5: 278 (1991).

KAWARABAYASHI, T, EXPRESSION OF APP IN THE EARLY STAGE OF BRAIN-DAMAGE, BRAIN RESEARCH 563: 334 (1991).

KITAGUCHI, N, NOVEL PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID PROTEIN SHOWS PROTEASE INHIBITORY ACTIVITY, NATURE 331: 530 (1988).

KOH, J.Y., BETA-AMYLOID PROTEIN INCREASES THE VULNERABILITY OF CULTURED CORTICAL-NEURONS TO EXCITOTOXIC DAMAGE, BRAIN RESEARCH 533: 315 (1990).

KOSIK, K.S., EPITOPES THAT SPAN THE TAU-MOLECULE ARE SHARED WITH PAIRED HELICAL FILAMENTS, NEURON 1: 817 (1988).

KOWALL, N.W., AN INVIVO MODEL FOR THE NEURODEGENERATIVE EFFECTS OF BETA-AMYLOID AND PROTECTION BY SUBSTANCE-P, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 7247 (1991).

10.1126/science.1899488

10.1126/science.2111584

MANN, DMA, THE PATTERN OF ACQUISITION OF PLAQUES AND TANGLES IN THE BRAINS OF PATIENTS UNDER 50 YEARS OF AGE WITH DOWNS-SYNDROME, JOURNAL OF THE NEUROLOGICAL SCIENCES 89: 169 (1989).

MANN, DMA, AN ANALYSIS OF THE MORPHOLOGY OF SENILE PLAQUES IN DOWNS-SYNDROME PATIENTS OF DIFFERENT AGES USING IMMUNOCYTOCHEMICAL AND LECTIN HISTOCHEMICAL TECHNIQUES, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 15: 317 (1989).

10.1073/pnas.82.12.4245

MATTSON, M.P., JOURNAL OF NEUROSCIENCE 12 376: (1992).

MATTSON, M.P., ANTIGENIC CHANGES SIMILAR TO THOSE SEEN IN NEUROFIBRILLARY TANGLES ARE ELICITED BY GLUTAMATE AND CA-2+ INFLUX IN CULTURED HIPPOCAMPAL-NEURONS, NEURON 4: 105 (1990).

MORTIMER, J.A., HEAD TRAUMA AS A RISK FACTOR FOR ALZHEIMERS-DISEASE - A COLLABORATIVE REANALYSIS OF CASE-CONTROL STUDIES, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 20: S28 (1991).

10.1126/science.1925564

NARUSE, S, MIS-SENSE MUTATION VAL-]ILE IN EXON-17 OF AMYLOID PRECURSOR PROTEIN GENE IN JAPANESE FAMILIAL ALZHEIMERS-DISEASE, LANCET 337: 978 (1991).

Neve, R. L., Molecular and Cellular Mechanisms of Neuronal Plasticity in Normal Aging and Alzheimer's Disease: 257 (1990).

NEVE, R.L., THE ALZHEIMER AMYLOID PRECURSOR-RELATED TRANSCRIPT LACKING THE BETA-A4 SEQUENCE IS SPECIFICALLY INCREASED IN ALZHEIMERS-DISEASE BRAIN, NEURON 5: 329 (1990).

NORDSTEDT, C, ALZHEIMER-BETA-A4 AMYLOID PRECURSOR PROTEIN IN HUMAN BRAIN - AGING-ASSOCIATED INCREASES IN HOLOPROTEIN AND IN A PROTEOLYTIC FRAGMENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 8910 (1991).

PALMERT, M.R., THE BETA-AMYLOID PROTEIN-PRECURSOR OF ALZHEIMER-DISEASE HAS SOLUBLE DERIVATIVES FOUND IN HUMAN-BRAIN AND CEREBROSPINAL-FLUID, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 6338 (1989).

PIKE, C.J., INVITRO AGING OF BETA-AMYLOID PROTEIN CAUSES PEPTIDE AGGREGATION AND NEUROTOXICITY, BRAIN RESEARCH 563: 311 (1991).

PONTE, P, A NEW A4-AMYLOID MESSENGER-RNA CONTAINS A DOMAIN HOMOLOGOUS TO SERINE PROTEINASE-INHIBITORS, NATURE 331: 525 (1988).

ROBAKIS, N.K., MOLECULAR-CLONING AND CHARACTERIZATION OF A CDNA-ENCODING THE CEREBROVASCULAR AND THE NEURITIC PLAQUE AMYLOID PEPTIDES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 4190 (1987).

ROBERTS, G.W., THE OCCULT AFTERMATH OF BOXING, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 53: 373 (1990).

ROBERTS, G.W., IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMERS-DISEASE - EVIDENCE FOR COMMON GENESIS, LANCET 2: 1456 (1988).

ROBERTS, G.W., BETA-A4 AMYLOID PROTEIN DEPOSITION IN BRAIN AFTER HEAD TRAUMA, LANCET 338: 1422 (1991).

ROHER, A, ALZHEIMERS-DISEASE - COATED VESICLES, COATED PITS AND THE AMYLOID-RELATED CELL, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 232: 367 (1988).

10.1056/NEJM198906013202203

SCHUBERT, D, CHARACTERIZATION OF AN AMYLOID BETA-PRECURSOR PROTEIN THAT BINDS HEPARIN AND CONTAINS TYROSINE SULFATE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 2066 (1989).

SELKOE, D. J., JOURNAL OF NEUROCHEMISTRY 46: 1820 (1986).

10.1016/0896-6273(91)90052-2

SIMAN, R, EXPRESSION OF BETA-AMYLOID PRECURSOR PROTEIN IN REACTIVE ASTROCYTES FOLLOWING NEURONAL DAMAGE, NEURON 3: 275 (1989).

SISODIA, S, JOURNAL OF CELL BIOLOGY 115: 61a (1991).

10.1126/science.1691865

TANZI, R.E., BIOCHEM BIOPH RES CO 166: 1192 (1990).

10.1126/science.2949367

10.1126/science.1971458

VANDUIJN, C.M., AMYLOID PRECURSOR PROTEIN GENE MUTATION IN EARLY-ONSET ALZHEIMERS-DISEASE, LANCET 337: 978 (1991).

10.1016/0092-8674(89)90177-3

WIRAK, D.O., J BIOL CHEM 266: 21331 (1991).

WISNIEWSKI, H.M., AMERICAN JOURNAL OF MEDICAL GENETICS 37 7: 287 (1990).

10.1126/science.2474201

YOSHIOKA, K, THE 717VAL-]ILE SUBSTITUTION IN AMYLOID PRECURSOR PROTEIN IS ASSOCIATED WITH FAMILIAL ALZHEIMERS-DISEASE REGARDLESS OF ETHNIC-GROUPS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 178: 1141 (1991).