Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice

Hippocampus - Tập 12 Số 1 - Trang 47-54 - 2002
Tammy L. Ivanco1,2, William T. Greenough3
1Beckman Institute, University of Illinois, Urbana, Illinois
2Department of Psychology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
3Departments of Psychology, Cell and Structural Biology, and Psychiatry, and Neuroscience Program, University of Illinois, Urbana, Illinois

Tóm tắt

AbstractThe fragile‐X mental retardation protein (FMRP) is greatly reduced or absent in individuals with fragile‐X mental retardation syndrome, a common, heritable form of mental retardation. Morphological studies suggest that this protein functions in normal synapse maturation and neuronal plasticity. Examination of human brain autopsy tissue has shown that fragile‐X patients exhibit long, thin spines more frequently, and stubby mushroom‐shaped spines less frequently, than these two types of spines are seen in normal autopsy tissue. Fragile‐X tissue also has a greater density of these spines along dendrites, which suggests a possible failure of synapse elimination. Fmr1 knockout mice and wild‐type littermates brains were processed for Timm staining, which reveals the zinc‐rich terminals of the dentate gyrus, the mossy fibers. The Fmr1 knockout mice exhibited a pattern of Timm granule‐staining within the stratum oriens of subfield CA3 and the inner molecular layer that was significantly different than staining seen in wild‐type animals. The sources and consequences of the altered terminal staining are unclear, but are discussed in relation to immature synapse morphology, a failure of normal regression of synapses, and a potential biological penalty of such a failure to regress. Hippocampus 2002;12:47–54. © 2002 Wiley‐Liss, Inc.

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Hippocampus

Tập 12 Số 1

47-54

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