Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice
Tóm tắt
The fragile‐X mental retardation protein (FMRP) is greatly reduced or absent in individuals with fragile‐X mental retardation syndrome, a common, heritable form of mental retardation. Morphological studies suggest that this protein functions in normal synapse maturation and neuronal plasticity. Examination of human brain autopsy tissue has shown that fragile‐X patients exhibit long, thin spines more frequently, and stubby mushroom‐shaped spines less frequently, than these two types of spines are seen in normal autopsy tissue. Fragile‐X tissue also has a greater density of these spines along dendrites, which suggests a possible failure of synapse elimination.
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Tài liệu tham khảo
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