Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington’s disease

Journal of Applied Physiology - Tập 82 Số 1 - Trang 262-269 - 1997
Jeffrey M. Hausdorff1,2, Susan L. Mitchell1,2,3, Renée Firtion4, Chung‐Kang Peng5, Merit Cudkowicz6, Jeanne Y. Wei1,2, Ary L. Goldberger4,5
1Gerontology Division, Beth Israel Hospital, Boston 02115
2Gerontology Division, Beth Israel Hospital, Boston 02115; and Division on Aging, Harvard Medical School, Boston 02115;
3Hebrew Rehabilitation Center for the Aged, Boston 02131;
4Biomedical Engineering Department, Boston University, Boston 02215;
5Cardiovascular Division, Beth Israel Hospital/Harvard Medical School, Boston 02215; and
6Neurology Department, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114

Tóm tắt

Hausdorff, Jeffrey M., Susan L. Mitchell, Renée Firtion, C. K. Peng, Merit E. Cudkowicz, Jeanne Y. Wei, and Ary L. Goldberger. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington’s disease. J. Appl. Physiol. 82(1): 262–269, 1997.—Fluctuations in the duration of the gait cycle (the stride interval) display fractal dynamics and long-range correlations in healthy young adults. We hypothesized that these stride-interval correlations would be altered by changes in neurological function associated with aging and certain disease states. To test this hypothesis, we compared the stride-interval time series of 1) healthy elderly subjects and young controls and of 2) subjects with Huntington’s disease and healthy controls. Using detrended fluctuation analysis, we computed α, a measure of the degree to which one stride interval is correlated with previous and subsequent intervals over different time scales. The scaling exponent α was significantly lower in elderly subjects compared with young subjects (elderly: 0.68 ± 0.14; young: 0.87 ± 0.15; P < 0.003). The scaling exponent α was also smaller in the subjects with Huntington’s disease compared with disease-free controls (Huntington’s disease: 0.60 ± 0.24; controls: 0.88 ± 0.17; P < 0.005). Moreover, α was linearly related to degree of functional impairment in subjects with Huntington’s disease ( r = 0.78, P < 0.0005). These findings demonstrate that stride-interval fluctuations are more random (i.e., less correlated) in elderly subjects and in subjects with Huntington’s disease. Abnormal alterations in the fractal properties of gait dynamics are apparently associated with changes in central nervous system control.

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Journal of Applied Physiology

Tập 82 Số 1

262-269

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