Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

International Journal of Developmental Neuroscience - Tập 31 - Trang 311-318 - 2013
Wafaa A. Hassan1, Taghride Abdel Rahman2, Mona S. Aly2, Asmaa S. Shahat1
1National Organisation for Drug Control and Research, Hormone Evaluation Department, 11511 Cairo, Egypt
2Cairo University, Faculty of Science, Zoology Department, Cairo 12613, Egypt

Tóm tắt

Abstract

The present study was conducted to investigate the effect of experimentally‐induced hyperthyroidism on dopamine (DA), norepinephrine (NE) and serotonin (5‐HT) levels in different brain regions as well as in blood plasma, cardiac muscle and adrenal gland of young and adult male albino rats (60 rats of each age). Hyperthyroidism was induced by daily s.c. injection of L‐thyroxine (L‐T4, 500 μg/kg body wt.) for 21 consecutive days. Induction of hyperthyroidism caused a significant elevation in DA and 5‐HT levels in most of the tissues studied of both young and adult animals after 7, 14, and 21 days. NE content significantly decreased after 21 days in most of the brain regions examined and after 14 and 21 days in blood plasma of young rats following hyperthyroidism. In adult rats, NE content decreased after 14 and 21 days in cardiac muscle and after 21 days only in adrenal gland. It may be suggested that the changes in monoamines level induced by hyperthyroidism may be due to disturbance in the synthesis, turnover and release of these amines through the neurons impairment or may attributed to an alteration pattern of their synthesis and/or degradative enzymes or changes in the sensitivity of their receptors


Tài liệu tham khảo

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