Alterations in intrinsic neuronal excitability during normal aging

Aging Cell - Tập 6 Số 3 - Trang 327-336 - 2007
John F. Disterhoft1, M. Matthew Oh
1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA. [email protected]

Tóm tắt

SummaryNormal aging subjects, including humans, have difficulty learning hippocampus‐dependent tasks. For example, at least 50% of normal aging rabbits and rats fail to meet a learning criterion in trace eyeblink conditioning. Many factors may contribute to this age‐related learning impairment. An important cause is the reduced intrinsic excitability observed in hippocampal pyramidal neurons from normal aging subjects, as reflected by an enlarged postburst afterhyperpolarization (AHP) and an increased spike‐frequency adaptation (accommodation). In this review, we will focus on the alterations in the AHP and accommodation during learning and normal aging. We propose that age‐related increases in the postburst AHP and accommodation in hippocampal pyramidal neurons play an integral role in the learning impairment observed in normal aging subjects.

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Tài liệu tham khảo

10.1016/0092-8674(94)90205-4

10.1016/0006-8993(95)00910-I

10.1037/h0077579

10.1126/science.1257783

10.1016/S0896-6273(00)80510-3

10.1016/j.tins.2005.06.003

10.1098/rstb.2003.1282

10.1113/jphysiol.1973.sp010274

10.1113/jphysiol.1973.sp010273

10.1523/JNEUROSCI.0182-04.2004

Campbell LW, 1996, Aging changes in voltage‐gated calcium currents in hippocampal CA1 neurons, J. Neurosci, 16, 6286, 10.1523/JNEUROSCI.16-19-06286.1996

10.1037/h0074822

10.1073/pnas.070056097

10.1101/lm.59603

10.1126/science.280.5360.77

10.1152/jn.1999.82.6.3139

10.1152/jn.1989.61.5.971

10.1073/pnas.83.8.2733

10.1016/0006-8993(88)90593-8

10.1016/j.tins.2006.08.005

10.1016/j.jphysparis.2005.12.079

10.1016/S0165-0173(99)00017-X

10.1177/107385840200800404

10.1523/JNEUROSCI.4171-05.2006

10.1093/cercor/10.10.952

Giese KP, 1998, Reduced K+ channel inactivation, spike broadening, and after‐hyperpolarization in Kvβ1.1 deficient mice with impaired learning, Learn. Mem, 5, 257, 10.1101/lm.5.4.257

Gormezano I, 1987, Classical Conditioning

Graves CA, 1985, Age‐related disruption of trace but not delay classical conditioning of the rabbit's nictitating membrane response, Behav. Neurosci, 99, 88, 10.1037/0735-7044.99.1.88

10.1113/jphysiol.2005.086835

10.1016/0197-4580(83)90053-2

10.1001/archneur.60.8.1119

10.1016/j.neuroscience.2005.05.044

10.1037/h0059822

10.1016/0197-4580(96)00030-9

10.1037/0735-7044.109.2.195

10.1016/S0166-2236(96)10081-3

10.1097/00001756-200110290-00040

10.1016/S0197-4580(00)00194-9

10.1037/0735-7044.115.4.747

10.1523/JNEUROSCI.0800-04.2004

10.1152/jn.2002.88.2.621

10.1152/jn.01148.2003

10.1016/j.brainres.2006.10.037

Kuo AG, 2004, Abstract Viewer/Itinerary Planner

10.1126/science.6494926

10.1113/jphysiol.1984.sp015378

10.1152/jn.1997.78.2.1030

10.1152/jn.2001.86.4.1839

10.1037/0735-7044.111.5.873

10.1037/0735-7044.104.2.243

Moyer JR, 2000, Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning, J. Neurosci, 20, 5476, 10.1523/JNEUROSCI.20-14-05476.2000

10.1152/jn.1992.68.6.2100

10.1523/JNEUROSCI.16-17-05536.1996

10.1016/j.cub.2004.10.021

10.1046/j.1460-9568.2003.02889.x

10.1038/nn1449

10.1126/science.2456612

10.1523/JNEUROSCI.18-09-03171.1998

10.1523/JNEUROSCI.1202-06.2006

10.1152/jn.01177.2002

10.1523/JNEUROSCI.19-05-01814.1999

Oh MM, 2004, Washington, DC

10.1111/j.1460-9568.2005.04551.x

10.1111/j.1460-9568.2006.04746.x

10.1016/S0896-6273(03)00810-9

10.1016/0006-8993(94)91195-9

Power JM, 2002, Age‐related enhancement of the slow outward calcium‐activated potassium current in hippocampal CA1 pyramidal neurons in vitro, J. Neurosci, 22, 7234, 10.1523/JNEUROSCI.22-16-07234.2002

10.1046/j.1460-9568.1998.00149.x

10.1523/JNEUROSCI.16-15-04537.1996

10.1016/S0301-0082(02)00004-7

10.1523/JNEUROSCI.22-22-09698.2002

Sametsky EA, 2001, Dorso‐ventral gradient of excitability in hippocampal pyramidal neurons, Soc. Neurosci. Abstr, 27

10.1126/science.136.3516.650

10.1152/jn.2002.87.6.2983

10.1037/0735-7044.100.5.729

10.1016/0959-4388(95)80023-9

Squire LR, 1999, Memory: From Mind to Molecules

10.1111/j.1471-4159.2004.02318.x

10.1038/nrn1516

10.1016/S0079-6123(08)61248-0

10.1523/JNEUROSCI.21-24-09744.2001

10.1126/science.272.5264.1017

10.1146/annurev.psych.56.091103.070239

10.1016/0006-8993(90)91830-A

10.1016/0197-4580(96)00026-7

10.1152/jn.1996.76.3.1836

10.1523/JNEUROSCI.5023-04.2005

Torres GE, 1996, 5‐Hydroxytryptamine4 receptors reduce afterhyperpolarization in hippocampus by inhibiting calcium‐induced calcium release, Mol. Pharmacol, 50, 1316

10.1002/hipo.10157

10.1046/j.1471-4159.2003.01681.x

10.1016/j.neuroscience.2006.04.065

10.1016/S0166-4328(98)00096-5

10.1016/0197-4580(91)90105-S

10.1037/0882-7974.3.3.219

10.1016/0197-4580(95)02064-0

10.1016/0006-8993(69)90076-6

10.1152/jn.00977.2003

10.1016/S1568-1637(01)00009-5

10.1093/cercor/bhi125